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Disease specificity of the brain morphologic changes in psychiatric disorders

Research Project

Project/Area Number 22591275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama

Principal Investigator

TAKAHASHI Tsutomu  富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)

Co-Investigator(Kenkyū-buntansha) SUZUKI Michio  富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
KAWASAKI Yasuhiro  富山大学, 大学病院, 講師 (80242519)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords精神生理学 / 脳画像診断学 / 統合失調症 / 磁気共鳴画像 / 嗅溝 / アットリスク精神状態 / 双極性感情障害 / 下垂体 / 統合失調型障害 / 側頭葉 / 双極性障害 / 上側頭回
Research Abstract

In this study, we used magnetic resonance imaging to investigate the disease specificity of brain morphologic changes in schizophrenia. Gray matter reduction in the superior temporal and anterior cingulate gyri existed prior to the onset of schizophrenia. Progressive gray matter loss in the temporal region during early stages was specific to schizophrenia among various psychiatric disorders. However, enlarged pituitary volume, which might reflect stress vulnerability, and alteration in the olfactory sulcus depth, a potential neurodevelopmental marker, were general findings among several neuropsychiatric disorders.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (17 results) (of which Invited: 2 results)

  • [Journal Article] Olfactory sulcus morphology in established bipolar affective disorder2014

    • Author(s)
      Takahashi T,et al
    • Journal Title

      Psychiatry Res Neuroimaging

      Volume: 222 Issue: 1-2 Pages: 114-117

    • DOI

      10.1016/j.pscychresns.2014.02.005

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders2014

    • Author(s)
      Takahashi T,et al
    • Journal Title

      Schizophr Res

      Volume: 153 Issue: 1-3 Pages: 18-24

    • DOI

      10.1016/j.schres.2014.01.041

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered depth of the olfactory sulcus in first-episode schizophrenia2013

    • Author(s)
      Takahashi T,et al
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 40 Issue: 1-3 Pages: 167-172

    • DOI

      10.1016/j.schres.2013.06.029

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gray matter changes in high-risk subjects for developing psychosis and first-episode schizophrenia: a voxel-based structural MRI study2013

    • Author(s)
      Nakamura K
    • Journal Title

      Fornt Psychiatry

      Volume: 4 Pages: 16-16

    • DOI

      10.3389/fpsyt.2013.00016

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal MRI study of the pituitary volume in chronic schizophrenia : a preliminary report2012

    • Author(s)
      Takahashi T,et al
    • Journal Title

      Psychiatry Res Neuroimaging

      Volume: 202 Issue: 1 Pages: 84-87

    • DOI

      10.1016/j.pscychresns.2011.11.008

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum2011

    • Author(s)
      Takahashi T, et al
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35 Issue: 8 Pages: 1957-1964

    • DOI

      10.1016/j.pnpbp.2011.07.009

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia2011

    • Author(s)
      Takahashi T, …Suzuki M, et al.
    • Journal Title

      Prog.Neuropsychopharmacol.Biol.Psychiatry

      Volume: 35 Issue: 1 Pages: 177-183

    • DOI

      10.1016/j.pnpbp.2010.10.023

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder2010

    • Author(s)
      Takahashi T, et al
    • Journal Title

      J Affect Disord

      Volume: 123 Issue: 1-3 Pages: 276-282

    • DOI

      10.1016/j.jad.2009.08.022

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia2010

    • Author(s)
      Takahashi T, et al
    • Journal Title

      Schizophr Res

      Volume: 119 Issue: 1-3 Pages: 65-74

    • DOI

      10.1016/j.schres.2009.12.006

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis2010

    • Author(s)
      Takahashi T, et al
    • Journal Title

      Br J Psychiatry

      Volume: 196 Issue: 3 Pages: 206-211

    • DOI

      10.1192/bjp.bp.109.069732

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis.2010

    • Author(s)
      Takahashi T
    • Journal Title

      Br J Psychiatry

      Volume: 196 Pages: 206-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia.2010

    • Author(s)
      Takahashi T
    • Journal Title

      Schizophr Res

      Volume: 119 Pages: 65-74

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Progressive gray matter reduction in the frontal and temporal lobe structures in schizophrenia spectrum2013

    • Author(s)
      Takahashi T
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 画像研究でみたARMSの縦断経過2013

    • Author(s)
      高橋努
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 統合失調症圏のMRI研究の進歩2013

    • Author(s)
      高橋努
    • Organizer
      第109回日本精神神経学会学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 統合失調症圏のMRI研究の進歩2013

    • Author(s)
      高橋 努
    • Organizer
      第109回日本精神神経学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 画像研究でみたARMSの縦断経過2013

    • Author(s)
      高橋 努
    • Organizer
      第109回日本精神神経学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Increased pituitary volume in early psychosis2012

    • Author(s)
      Takahashi T
    • Organizer
      8th International Conference on Early Psychosis
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Final Research Report
  • [Presentation] 早期精神病における下垂体体積2012

    • Author(s)
      高橋 努
    • Organizer
      第16回日本精神保健予防学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Insular cortex volume in bipolar I disorder2012

    • Author(s)
      Takahashi T
    • Organizer
      第34回生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Increased pituitasry volume in early psychosis2012

    • Author(s)
      Takahashi T
    • Organizer
      8th International Conference on Early Psychosis
    • Place of Presentation
      San Fransisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 早期精神病における脳形態変化2011

    • Author(s)
      高橋努
    • Organizer
      第15回日本精神保健予防学会
    • Place of Presentation
      ベルサール九段(東京)(招待講演)
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 精神疾患の脳形態2011

    • Author(s)
      高橋努
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      京王プラザホテル(東京)(招待講演)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] A follow-up MRI study of the temporal lobe structures in schizophrenia spectrum2011

    • Author(s)
      Takahashi T
    • Organizer
      3rd World Congress of Asian Psychiatry
    • Place of Presentation
      Melbourne Convention and Exhibition Centre (Melbourne)
    • Year and Date
      2011-08-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 早期精神病における脳形態変化2011

    • Author(s)
      高橋努
    • Organizer
      第15回日本精神保健予防学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 精神疾患の脳形態2011

    • Author(s)
      高橋努
    • Organizer
      第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] A follow-up MRI study of the temporal lobe structures in schizophrenia spectrum2011

    • Author(s)
      Takahashi T
    • Organizer
      3^<rd> World Congress of Asian Psychiatry
    • Place of Presentation
      Melbourne
    • Related Report
      2013 Final Research Report
  • [Presentation] An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders2010

    • Author(s)
      Takahashi T
    • Organizer
      7^<th> international conference on early psychosis
    • Place of Presentation
      Amsterdam
    • Related Report
      2013 Final Research Report
  • [Presentation] An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders2010

    • Author(s)
      Takahashi T
    • Organizer
      7th international conference on early psychosis
    • Place of Presentation
      Amsterdam
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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