| Project/Area Number |
22591275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Toyama |
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Principal Investigator |
TAKAHASHI Tsutomu 富山大学, 大学院医学薬学研究部(医学), 准教授 (60345577)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Michio 富山大学, 大学院医学薬学研究部(医学), 教授 (40236013)
KAWASAKI Yasuhiro 富山大学, 大学病院, 講師 (80242519)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 精神生理学 / 脳画像診断学 / 統合失調症 / 磁気共鳴画像 / 嗅溝 / アットリスク精神状態 / 双極性感情障害 / 下垂体 / 統合失調型障害 / 側頭葉 / 双極性障害 / 上側頭回 |
|---|
| Research Abstract |
In this study, we used magnetic resonance imaging to investigate the disease specificity of brain morphologic changes in schizophrenia. Gray matter reduction in the superior temporal and anterior cingulate gyri existed prior to the onset of schizophrenia. Progressive gray matter loss in the temporal region during early stages was specific to schizophrenia among various psychiatric disorders. However, enlarged pituitary volume, which might reflect stress vulnerability, and alteration in the olfactory sulcus depth, a potential neurodevelopmental marker, were general findings among several neuropsychiatric disorders.
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