| Project/Area Number |
22591278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Fukui |
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Principal Investigator |
WADA Yuji 福井大学, 医学部附属病院, 教授 (30175153)
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| Co-Investigator(Renkei-kenkyūsha) |
MURATA Tetsuhito 福井大学, 医学部, 准教授(H22-H23) (80200294)
TAKAHASHI Tetsuya 福井大学, 医学部附属病院, 講師 (00377459)
KOSAKA Hirotaka 福井大学, 子どものこころの発達研究センター, 特命准教授 (70401966)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 精神生理学 / 統合失調症 / 5-HT1Aアゴニスト / CANTAB / 認知機能障害 / 前頭葉機能 / 脳イメージング / 機能的MRI / 認知機能 / 脳波解析 |
|---|
| Research Abstract |
We performed a series of studies to explore the pathophysiology underlying cognitive dysfunction in schizophrenia. In a non-linear EEG analysis, patients showed higher complexity at higher time scales than healthy controls over the fronto-temporal regions. Secondly, we investigated amygdala responses during facial recognition using a functional magnetic resonance imaging; Schizophrenia patients showed more prominent activation of the right amygdala than controls. In contrast, individuals with high-functioning autism spectrum disorders showed less amygdala activity than controls during facial recognition task. Finally, we assessed the effects of tandospirone, a serotonin-1A partial agonist, and found the improvement of frontal cognitive dysfunction of patients detected by Cambridge Neuropsychological Test Automated Battery.
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