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Molecular imaging study on dopaminergic system in autism: in relation to deficits in memory reconstruction

Research Project

Project/Area Number 22591280
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

TAKAGAI Shu  浜松医科大学, 子どものこころの発達研究センター, 准教授 (10447807)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Kazuhiko  弘前大学, 医学系研究科, 教授 (80263911)
SUZUKI Katsuaki  浜松医科大学, 医学部, 准教授 (00285040)
IWATA Yasuhide  浜松医科大学, 医学部附属病院, 講師 (10285025)
OUSHI Yasuomi  浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
TAKEBAYASHI Kiyokazu  浜松医科大学, 医学部附属病院, 講師 (50397428)
MORI Norio  浜松医科大学, 医学部, 教授 (00174376)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords児童 / 思春期精神医学 / 分子イメージング / ドパミン系 / PET / 自閉症 / 児童・思春期精神医学 / 記憶障害
Research Abstract

Using positron emission tomography (PET), we measured the binding of brain dopamine D1 receptors in fifteen men with high-functioning autism and 15 age- and IQ-matched control subjects with the radioligand [11C]SCH23390. Statistical parametric mapping was used for between-subject analysis and within-subject correlation analysis withrespect to clinical variables.Analyses are still ongoing.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (6 results)

  • [Journal Article] Microglial activation in young adults with autism spectrum disorder2013

    • Author(s)
      Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, Yoshihara Y, Omata K, Matsumoto K, Tsuchiya KJ, Iwata Y, Tsujii M, Sugiyama T, Mori N
    • Journal Title

      JAMA Psychiatry

      Volume: 70 Pages: 49-58

    • Related Report
      2012 Final Research Report
  • [Journal Article] Microglial activation in young adults with autism spectrum disorder2013

    • Author(s)
      Suzuki K
    • Journal Title

      JAMA Psychiatry

      Volume: 70 Issue: 1 Pages: 49-58

    • DOI

      10.1001/jamapsychiatry.2013.272

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in intractable tardive dystonia in bipolar disorder after aripiprazole treatment: a case report2012

    • Author(s)
      Takagai S, Nakasato K, Suzuki K, Kasai E, Isogai S, Morimoto S, Mori N
    • Journal Title

      J Clin Psychopharmacol

      Volume: 32 Pages: 563-4

    • Related Report
      2012 Final Research Report
  • [Journal Article] HBC Study Team. Psychosocial determinants of mistimed and unwanted pregnancy: the Hamamatsu Birth Cohort (HBC) study2012

    • Author(s)
      Takahashi S, Tsuchiya KJ, Matsumoto K, Suzuki K, Mori N, Takei N
    • Journal Title

      Matern Child Health J

      Volume: 16 Pages: 947-55

    • Related Report
      2012 Final Research Report
  • [Journal Article] Improvement in intractable tardive dystonia in bipolar disorder after aripiprazole treatment: a case report.2012

    • Author(s)
      Takagai S, Suzuki K, Mori N, et al.
    • Journal Title

      J Clin Psychopharmacol.

      Volume: 32 Issue: 4 Pages: 563-564

    • DOI

      10.1097/jcp.0b013e31825dde22

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Psychosocial determinants of mistimed and unwanted pregnancy: the Hamamatsu Birth Cohort (HBC) Study2012

    • Author(s)
      Takahashi
    • Journal Title

      Maternal & Child Health Journal

      Volume: 16 Issue: 5 Pages: 947-955

    • DOI

      10.1007/s10995-011-0881-y

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes2012

    • Author(s)
      Thanseem I
    • Journal Title

      Biol Psychiatry

      Volume: 71 Pages: 410-418

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the serum levels of anterior pituitary hormones in male children with autism2011

    • Author(s)
      Iwata K
    • Journal Title

      Mol Autism

      Volume: 2 Pages: 16-16

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of plasma glutamate and glutamine levels in children with high-functioning autism2011

    • Author(s)
      Shimmura C
    • Journal Title

      PloS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of transcription factor gene LMX1B with autism2011

    • Author(s)
      Thanseem I
    • Journal Title

      PloS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism2011

    • Author(s)
      Suda S
    • Journal Title

      Mol Autism

      Volume: 2 Pages: 14-14

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders2011

    • Author(s)
      Suzuki K
    • Journal Title

      PloS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011

    • Author(s)
      Suzuki K
    • Journal Title

      Arch Gen Psychiatry

      Volume: 68 Pages: 306-313

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism.2010

    • Author(s)
      Suzuki K
    • Journal Title

      Int J Neuropsychopharmacol.

      Volume: 13 Pages: 529-534

    • NAID

      120005305395

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain serotonin and dopamine transporter bindings in adults with high-functioning autism.2010

    • Author(s)
      Nakamura K
    • Journal Title

      Arch Gen Psychiatry.

      Volume: 67 Pages: 59-68

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 自閉症の生物学的研究について:PET画像研究他2011

    • Author(s)
      中村和彦
    • Organizer
      第52回日本児童青年精神医学会総会
    • Place of Presentation
      徳島市
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 自閉症の生物学的研究について(PET他)2011

    • Author(s)
      中村和彦
    • Organizer
      第16回グリア研究会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism2010

    • Author(s)
      Nakamura K
    • Organizer
      40th annual meeting of the Society for Neuroscience
    • Place of Presentation
      40th annual meeting of the Society for Neuroscience
    • Year and Date
      2010-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K
    • Organizer
      40th annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism2010

    • Author(s)
      Nakamura K
    • Organizer
      9th Annual International Meeting For Autism Research
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2010-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K
    • Organizer
      9^<th> Annual International Meeting For Autism Research
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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