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Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.

Research Project

Project/Area Number 22591284
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

OKOCHI Masayasu  大阪大学, 医学系研究科, 講師 (90335357)

Co-Investigator(Kenkyū-buntansha) TAGAMI Shinji  大阪大学, 医学(系)研究科(研究院), 助教 (40362735)
TAKEDA Masatoshi  大阪大学, 医学(系)研究科(研究院), 教授 (00179649)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords精神神経疾患 / 質量分析法 / 脳脊髄液 / 精神神経科学 / 質量分析 / 疾患関連物質探索 / 精神神経疾 / 質量分析解析 / ペプチド / アミノ酸配列決定 / 神経変性疾患 / 精神疾患 / LC/MS/MS / プロテオームリサーチ / バイオマーカー / 超微量物質定量
Research Abstract

By using LC/MS/MS analysis, we tried to detect brain peptides which are associated with psychiatric disorders. We used CSF of patients with or withoutpsychiatric disorders. We detected and compared the levels of more than a thousand of peptides of which amino-acid sequences were determined by us. However, we could not successfully detect any specific peptides, so far . We will continue the study to find endogenous compounds which are associated with psychiatric conditions.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (66 results)

All 2013 2012 2011 2010 Other

All Journal Article (29 results) (of which Peer Reviewed: 12 results) Presentation (22 results) (of which Invited: 4 results) Book (11 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] γ -secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ432013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M,Kodama TS, Mori K, Nakayama T, Ihara Y,Takeda M
    • Journal Title

      Cell Rep

      Volume: 3 Pages: 42-51

    • Related Report
      2012 Final Research Report
  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia.2013

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
    • Journal Title

      World J Biol Psychiatry

      Volume: 14 Pages: 100-13

    • Related Report
      2012 Final Research Report
  • [Journal Article] γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.2013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
    • Journal Title

      Cell Rep.

      Volume: 3(1) Issue: 1 Pages: 42-51

    • DOI

      10.1364/oe.21.000322

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of endoplasmic reticulum stress in tauopathy.2013

    • Author(s)
      Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 430(2) Issue: 2 Pages: 500-4

    • DOI

      10.1016/j.bbrc.2012.12.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs2012

    • Author(s)
      Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Non-pharmacological intervention for dementia patients.2012

    • Author(s)
      Takeda M, Tanaka T, Okochi M, Kazui H
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66 Pages: 1-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Ab40/42 production detected using fusion constructs2012

    • Author(s)
      Sato N
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e48551-e48551

    • DOI

      10.1371/journal.pone.0048551

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-pharmacological intervention for dementia patients2012

    • Author(s)
      Takeda M, Tanaka T, Okochi M, Kazui H
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66(1) Issue: 1 Pages: 1-7

    • DOI

      10.1111/j.1440-1819.2011.02304.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-pharmacological intervention for dementia patients2012

    • Author(s)
      Takeda M, Tanaka T, Okochi M, Kazui H
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66 Pages: 1-7

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of endoplasmic reticulum stress in tauopathy.2011

    • Author(s)
      Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 430 Pages: 500-4

    • Related Report
      2012 Final Research Report
  • [Journal Article] [Behavioral and psychological symptoms of dementia]2011

    • Author(s)
      Okochi M, Takeda M
    • Journal Title

      Nihon Rinsho.

      Volume: 8 Pages: 308-12

    • Related Report
      2012 Final Research Report
  • [Journal Article] PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011

    • Author(s)
      Sigma-1Rs are upregulated via Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415 Pages: 519-25

    • Related Report
      2012 Final Research Report
  • [Journal Article] New drugs for Alzheimer's disease in Japan2011

    • Author(s)
      Takeda M, Tanaka T, Okochi M.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 65 Pages: 399-404

    • Related Report
      2012 Final Research Report
  • [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011

    • Author(s)
      Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 11 Pages: 90-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population.2011

    • Author(s)
      Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
    • Journal Title

      World J Biol Psychiatry

      Volume: 11 Pages: 852-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
    • Journal Title

      World J Biol Psychiatry.2011 Dec 12

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress2011

    • Author(s)
      Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415 Pages: 519-25

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings.2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 64 Pages: 592-607

    • Related Report
      2012 Final Research Report
  • [Journal Article] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.2010

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

      Volume: 153 Pages: 1459-64

    • Related Report
      2012 Final Research Report
  • [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010

    • Author(s)
      Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T
    • Journal Title

      Dement Geriatr Cogn Disord.

      Volume: 30 Pages: 302-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010

    • Author(s)
      Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, FujiiK, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Take da M.
    • Journal Title

      Psychogeriatrics.

      Volume: 10 Pages: 117-23

    • NAID

      10029771051

    • Related Report
      2012 Final Research Report
  • [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010

    • Author(s)
      Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 14920-31

    • Related Report
      2012 Final Research Report
  • [Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.2010

    • Author(s)
      Okochi M, Tagami S, Takeda M
    • Journal Title

      Neurodegener Dis.

      Volume: 7 Pages: 42-5

    • Related Report
      2012 Final Research Report
  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.2010

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
    • Journal Title

      Schizophr Res.

      Volume: 116 Pages: 126-32

    • Related Report
      2012 Final Research Report
  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010

    • Author(s)
      Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 10 Pages: 117-123

    • NAID

      10029771051

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010

    • Author(s)
      Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 14290-14931

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010

    • Author(s)
      Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
    • Journal Title

      BMC Complement Altern Med.

      Volume: 10 Pages: 1-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010

    • Author(s)
      Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 30 Pages: 302-308

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64 Pages: 592-607

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Potential Action Mechanism of γ-Secretase Modulators2013

    • Author(s)
      Okochi M
    • Organizer
      AD/PD2013
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2013-10-06
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Ab42 is an intermediated stopover product of PS/g-secrease2013

    • Author(s)
      Okochi M
    • Organizer
      SFB seminor
    • Place of Presentation
      LMU, Munich
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012

    • Author(s)
      大河内 正康 田上 真次 柳田 寛太児玉 高志 武田 雅俊
    • Organizer
      第31回日本認知症学会学術集会 トピックス徹底討論「抗 Ab 療法の最新現状と徹底討論」
    • Place of Presentation
      つくば国際会議場、第4 会場 2F 中ホール
    • Year and Date
      2012-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] アルツハイマー病発症前診断バイオマーカーの開発 脳プロ課題 F ・アミロイドβ42 産生の上流機構の解析(武田班)2012

    • Author(s)
      大河内正康 田上 真次 朝長毅 武田雅俊
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      会場:E 会場(神戸国際会議場502)
    • Year and Date
      2012-09-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012

    • Author(s)
      Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
    • Organizer
      Alzheimer's Association International Conference 2012
    • Place of Presentation
      Vancouver Convention & Exhibition Centre, Vancouver Canada
    • Year and Date
      2012-07-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 「γセクレターゼ修飾薬(GSM)のアルツハイマー予防薬としての理論と実際」2012

    • Author(s)
      大河内正康
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] アルツハイマー病発症前診断バイオマーカーの開発2012

    • Author(s)
      大河内正康
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] アルツハイマー病のバイオマーカーと新しい診断基準2012

    • Author(s)
      大河内正康
    • Organizer
      第19回近畿老年期認知症研究会
    • Place of Presentation
      リーガロイヤルNCB、大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] S15-4 認知症バイオマーカーと次世代認知症治療戦略2011

    • Author(s)
      大河内正康
    • Organizer
      第21回日本臨床精神神経薬理学会, 第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      第2 会場(コンコード B)シンポジウム 15 認知症の病態理解から診断・治療法へ
    • Year and Date
      2011-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Biochemistry of "Ab-like Peptide", a novel type of peptide family2011

    • Author(s)
      Masayasu Okochi
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-07-24
    • Related Report
      2012 Final Research Report
  • [Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab422011

    • Author(s)
      Masayasu Okochi
    • Organizer
      AAICAD2011
    • Place of Presentation
      Paris Porte de Versailles, Convention and Exhibition Center, France
    • Year and Date
      2011-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab422011

    • Author(s)
      Masayasu Okochi
    • Organizer
      AAICAD2011, July 16-21, 2011
    • Place of Presentation
      Paris Porte de Versailles, Convention and Exhibition Center Paris, France(招待講演)
    • Year and Date
      2011-07-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Session Title: A Return to the Basics- Molecular Decoding of the Alzheimer's Disease Pathogenesis""アルツハイマー病治療薬γセクレターゼ・モジュレーターの理論とその将来的優位性について2011

    • Author(s)
      大河内正康
    • Organizer
      第33回生物学的精神医学会
    • Place of Presentation
      シンポジウム2・アルツハイマー病治療薬の新たな展開 ホテルグランパシフィック LE DAIBA・パレロワイヤル B
    • Year and Date
      2011-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Aβ様ペプチドの分泌から見えること-Aβ産生過程の発症への関与の可能性2010

    • Author(s)
      大河内正康
    • Organizer
      第29回日本認知症学会・シンポジウム 7
    • Place of Presentation
      名古屋ウインク愛知・第2 会場
    • Year and Date
      2010-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] アルツハイマー病Aβとは何か?Aβとよく似た生理ペプチドの発見とその応用についてPractical use of novel physiological peptides produced by beta-and gamma-secretases.2010

    • Author(s)
      大河内正康
    • Organizer
      つくばブレインサイエンスセミナー(TBSA)講演会
    • Place of Presentation
      筑波大学付属病院講堂
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease2010

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takeda M
    • Organizer
      Alzheimer's Association International Conference o Alzheimer's Disease 2010
    • Place of Presentation
      Honolulu Hawaii U.S.A
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] New aspects of pathophysiology and therapeutic/diagnostic strategy of dementia The ratio of CSF APL1beta28, a surrogate marker for Abeta422010

    • Author(s)
      Masa Okochi
    • Organizer
      increases before onset of sporadic Alzheimer diseaseICAD2010
    • Place of Presentation
      Hawaii Convention Center,Honolulu, Hawaii. Oral session
    • Year and Date
      2010-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Abeta全体を産生する仕組みはアルツハイマー病で加速されているか?-患者CSFを用いた解析2010

    • Author(s)
      大河内正康, 田上真次, 柳田寛太, 池内健, 秋山治彦, 徳田隆彦, 武田雅俊
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋市ウインク愛知
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta 28について2010

    • Author(s)
      田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
    • Organizer
      日本ヒトプロテオーム機構第8回大会
    • Place of Presentation
      東京ベイホテル東急
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients2010

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Levels of the surrogate marker for Abeta42(i.e., APL1beta)in CSF of sporadic Alzheimer disease patients increase before the onset of its clinical symptoms2010

    • Author(s)
      Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Determination of Amino acid sequences of several thousand peptides in human cerebrospinal fluid2010

    • Author(s)
      Kodama S, Okochi M, Tagami S, Yanagida K, Nakayama T, Tatsumi S, Mori K, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Book] 日本発Aβ42サロゲートマーカーの発見と性質 ― アルツハイマー病の発症前診断マーカーへの応用の可能性2013

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      精神神経学雑誌
    • Related Report
      2012 Annual Research Report
  • [Book] アミロイドカスケードの異常を反映するAβ42サロゲートマーカーAPL1β282013

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      老年精神医学
    • Related Report
      2012 Annual Research Report
  • [Book] アルツハイマー病薬開発の現状2012

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      脳21
    • Related Report
      2012 Annual Research Report
  • [Book] アルツハイマー病バイオマーカーについて2012

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      脳21
    • Related Report
      2012 Annual Research Report
  • [Book] 認知症学-その解明と治療の最新知見III.臨床編認知症の症候学各論2011

    • Author(s)
      大河内正康, 武田雅俊
    • Publisher
      (株)日本臨牀社
    • Related Report
      2011 Annual Research Report
  • [Book] 今、開発されている認知症(アルツハイマー病)の根本治療薬は?2010

    • Author(s)
      大河内正康
    • Publisher
      日本医事新報社
    • Related Report
      2010 Annual Research Report
  • [Book] アルツハイマー病Abeta42のサロゲートマーカーAPL1beta28ペプチドの発見:孤発性アルツハイマー病患者脳でAbeta42の産生増大が起こっている可能性について2010

    • Author(s)
      大河内正康、田上真次、柳田寛太、武田雅俊
    • Publisher
      日本神経精神薬理学雑誌
    • Related Report
      2010 Annual Research Report
  • [Book] アルツハイマー病老人班に蓄積するAbeta42産生の仕組みはどこまでわかったか?また、その成果の臨床応用の可能性について2010

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      金芳堂脳21
    • Related Report
      2010 Annual Research Report
  • [Book] プレセニリン研究の過去と現在2010

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      老年精神医学雑誌
    • Related Report
      2010 Annual Research Report
  • [Book] 新規脳内ペプチドAPL1beta28の測定結果からアルツハイマー病をみる2010

    • Author(s)
      大河内正康、田上真次、柳田寛太、武田雅俊
    • Publisher
      メディカルレビュー社 Pharma Medica
    • Related Report
      2010 Annual Research Report
  • [Book] 中核症状と周辺症状-アルツハイマー病アップデート2010

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      中外医学社 Clinical Neuroscience
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.osaka-u.ac.jp/en/research/annual-report/volume-4/graphics/24.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.osaka-u.ac.jp/en/research/annual-report/volume-9/100_select_paper/biology02.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.osaka-u.ac.jp/en/research/annual-report/volume-11/100_select_paper/copy6_of_science02.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010

    • Inventor(s)
      大河内正康、田上真次、武田雅俊、西冨晃平
    • Industrial Property Rights Holder
      大河内正康、田上真次、武田雅俊、西冨晃平
    • Filing Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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