Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.
| Project/Area Number |
22591284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAGAMI Shinji 大阪大学, 医学(系)研究科(研究院), 助教 (40362735)
TAKEDA Masatoshi 大阪大学, 医学(系)研究科(研究院), 教授 (00179649)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 精神神経疾患 / 質量分析法 / 脳脊髄液 / 精神神経科学 / 質量分析 / 疾患関連物質探索 / 精神神経疾 / 質量分析解析 / ペプチド / アミノ酸配列決定 / 神経変性疾患 / 精神疾患 / LC/MS/MS / プロテオームリサーチ / バイオマーカー / 超微量物質定量 |
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| Research Abstract |
By using LC/MS/MS analysis, we tried to detect brain peptides which are associated with psychiatric disorders. We used CSF of patients with or withoutpsychiatric disorders. We detected and compared the levels of more than a thousand of peptides of which amino-acid sequences were determined by us. However, we could not successfully detect any specific peptides, so far . We will continue the study to find endogenous compounds which are associated with psychiatric conditions.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia.2013
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
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Journal Title
World J Biol Psychiatry
Volume: 14
Pages: 100-13
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[Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs2012
Author(s)
Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.
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[Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011
Author(s)
Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
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Journal Title
Psychogeriatrics
Volume: 11
Pages: 90-7
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[Journal Article] Association study of KIBRA gene with memory performance in a Japanese population.2011
Author(s)
Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
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Journal Title
World J Biol Psychiatry
Volume: 11
Pages: 852-7
Related Report
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[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
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Journal Title
World J Biol Psychiatry.2011 Dec 12
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.2010
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
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Journal Title
Am J Med Genet B Neuropsychiatr Genet.
Volume: 153
Pages: 1459-64
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[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
Author(s)
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T
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Journal Title
Dement Geriatr Cogn Disord.
Volume: 30
Pages: 302-8
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[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
Author(s)
Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, FujiiK, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Take da M.
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Journal Title
Psychogeriatrics.
Volume: 10
Pages: 117-23
NAID
Related Report
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[Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.2010
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
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Journal Title
Schizophr Res.
Volume: 116
Pages: 126-32
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[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
Author(s)
Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
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Journal Title
Psychogeriatrics
Volume: 10
Pages: 117-123
NAID
Related Report
Peer Reviewed
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[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
Author(s)
Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
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Journal Title
Dement Geriatr Cogn Disord
Volume: 30
Pages: 302-308
Related Report
Peer Reviewed
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[Presentation] Levels of the surrogate marker for Abeta42(i.e., APL1beta)in CSF of sporadic Alzheimer disease patients increase before the onset of its clinical symptoms2010
Author(s)
Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Takeda M
Organizer
第53回日本神経化学会(神戸)大会Neuro2010
Place of Presentation
神戸コンベンションセンター
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