Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.

• Project/Area Number: 22591284
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: OKOCHI Masayasu 大阪大学, 医学系研究科, 講師 (90335357)
• Co-Investigator(Kenkyū-buntansha): TAGAMI Shinji 大阪大学, 医学(系)研究科(研究院), 助教 (40362735) ; TAKEDA Masatoshi 大阪大学, 医学(系)研究科(研究院), 教授 (00179649)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 精神神経疾患 / 質量分析法 / 脳脊髄液 / 精神神経科学 / 質量分析 / 疾患関連物質探索 / 精神神経疾 / 質量分析解析 / ペプチド / アミノ酸配列決定 / 神経変性疾患 / 精神疾患 / LC/MS/MS / プロテオームリサーチ / バイオマーカー / 超微量物質定量

Research Abstract

By using LC/MS/MS analysis, we tried to detect brain peptides which are associated with psychiatric disorders. We used CSF of patients with or withoutpsychiatric disorders. We detected and compared the levels of more than a thousand of peptides of which amino-acid sequences were determined by us. However, we could not successfully detect any specific peptides, so far . We will continue the study to find endogenous compounds which are associated with psychiatric conditions.

Research Products

• [Journal Article] γ -secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43 (2013)
  • Author(s): Okochi M, Tagami S, Yanagida K, Takami M,Kodama TS, Mori K, Nakayama T, Ihara Y,Takeda M
  • Journal Title: Cell Rep Volume: 3 Pages: 42-51
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia. (2013)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry Volume: 14 Pages: 100-13
• [Journal Article] γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. (2013)
  • Author(s): Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
  • Journal Title: Cell Rep. Volume: 3(1) Issue: 1 Pages: 42-51
  • DOI: 10.1364/oe.21.000322
  • Peer Reviewed
• [Journal Article] Involvement of endoplasmic reticulum stress in tauopathy. (2013)
  • Author(s): Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 430(2) Issue: 2 Pages: 500-4
  • DOI: 10.1016/j.bbrc.2012.12.007
  • Peer Reviewed
• [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs (2012)
  • Author(s): Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.
  • Journal Title: PLoS One Volume: 7
• [Journal Article] Non-pharmacological intervention for dementia patients. (2012)
  • Author(s): Takeda M, Tanaka T, Okochi M, Kazui H
  • Journal Title: Psychiatry Clin Neurosci Volume: 66 Pages: 1-7
• [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Ab40/42 production detected using fusion constructs (2012)
  • Author(s): Sato N
  • Journal Title: PLoS One Volume: 7 Issue: 11 Pages: e48551-e48551
  • DOI: 10.1371/journal.pone.0048551
  • Peer Reviewed
• [Journal Article] Non-pharmacological intervention for dementia patients (2012)
  • Author(s): Takeda M, Tanaka T, Okochi M, Kazui H
  • Journal Title: Psychiatry Clin Neurosci Volume: 66(1) Issue: 1 Pages: 1-7
  • DOI: 10.1111/j.1440-1819.2011.02304.x
  • Peer Reviewed
• [Journal Article] Non-pharmacological intervention for dementia patients (2012)
  • Author(s): Takeda M, Tanaka T, Okochi M, Kazui H
  • Journal Title: Psychiatry Clin Neurosci Volume: 66 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Involvement of endoplasmic reticulum stress in tauopathy. (2011)
  • Author(s): Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M
  • Journal Title: Biochem Biophys Res Commun Volume: 430 Pages: 500-4
• [Journal Article] [Behavioral and psychological symptoms of dementia] (2011)
  • Author(s): Okochi M, Takeda M
  • Journal Title: Nihon Rinsho. Volume: 8 Pages: 308-12
• [Journal Article] PERK/eIF2α/ATF4 pathway and execute protective function in ER stress. (2011)
  • Author(s): Sigma-1Rs are upregulated via Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
  • Journal Title: Biochem Biophys Res Commun Volume: 415 Pages: 519-25
• [Journal Article] New drugs for Alzheimer's disease in Japan (2011)
  • Author(s): Takeda M, Tanaka T, Okochi M.
  • Journal Title: Psychiatry Clin Neurosci Volume: 65 Pages: 399-404
• [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death. (2011)
  • Author(s): Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
  • Journal Title: Psychogeriatrics Volume: 11 Pages: 90-7
• [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population. (2011)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry Volume: 11 Pages: 852-7
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia (2011)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
  • Journal Title: World J Biol Psychiatry.2011 Dec 12 Volume: (In press)
  • Peer Reviewed
• [Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress (2011)
  • Author(s): Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
  • Journal Title: Biochem Biophys Res Commun Volume: 415 Pages: 519-25
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings. (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
  • Journal Title: Psychiatry Clin Neurosci. Volume: 64 Pages: 592-607
• [Journal Article] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia. (2010)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. Volume: 153 Pages: 1459-64
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T
  • Journal Title: Dement Geriatr Cogn Disord. Volume: 30 Pages: 302-8
• [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, FujiiK, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Take da M.
  • Journal Title: Psychogeriatrics. Volume: 10 Pages: 117-23
  • NAID: 10029771051
• [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. (2010)
  • Author(s): Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
  • Journal Title: J Biol Chem. Volume: 285 Pages: 14920-31
• [Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients. (2010)
  • Author(s): Okochi M, Tagami S, Takeda M
  • Journal Title: Neurodegener Dis. Volume: 7 Pages: 42-5
• [Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. (2010)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
  • Journal Title: Schizophr Res. Volume: 116 Pages: 126-32
• [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
  • Journal Title: Psychogeriatrics Volume: 10 Pages: 117-123
  • NAID: 10029771051
  • Peer Reviewed
• [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. (2010)
  • Author(s): Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
  • Journal Title: J Biol Chem Volume: 285 Pages: 14290-14931
  • Peer Reviewed
• [Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients. (2010)
  • Author(s): Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
  • Journal Title: BMC Complement Altern Med. Volume: 10 Pages: 1-7
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30 Pages: 302-308
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings. (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Pages: 592-607
  • Peer Reviewed
• [Presentation] Potential Action Mechanism of γ-Secretase Modulators (2013)
  • Author(s): Okochi M
  • Organizer: AD/PD2013
  • Place of Presentation: Florence, Italy
  • Year and Date: 2013-10-06
• [Presentation] Ab42 is an intermediated stopover product of PS/g-secrease (2013)
  • Author(s): Okochi M
  • Organizer: SFB seminor
  • Place of Presentation: LMU, Munich
  • Invited
• [Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際 (2012)
  • Author(s): 大河内 正康 田上 真次 柳田 寛太児玉 高志 武田 雅俊
  • Organizer: 第31回日本認知症学会学術集会 トピックス徹底討論「抗 Ab 療法の最新現状と徹底討論」
  • Place of Presentation: つくば国際会議場、第4 会場 2F 中ホール
  • Year and Date: 2012-10-28
• [Presentation] アルツハイマー病発症前診断バイオマーカーの開発 脳プロ課題 F ・アミロイドβ42 産生の上流機構の解析(武田班) (2012)
  • Author(s): 大河内正康 田上 真次 朝長毅 武田雅俊
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 会場:E 会場(神戸国際会議場502)
  • Year and Date: 2012-09-30
• [Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP2 (2012)
  • Author(s): Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancouver Convention & Exhibition Centre, Vancouver Canada
  • Year and Date: 2012-07-18
• [Presentation] 「γセクレターゼ修飾薬(GSM)のアルツハイマー予防薬としての理論と実際」 (2012)
  • Author(s): 大河内正康
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば国際会議場
  • Invited
• [Presentation] アルツハイマー病発症前診断バイオマーカーの開発 (2012)
  • Author(s): 大河内正康
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸国際会議場
  • Invited
• [Presentation] アルツハイマー病のバイオマーカーと新しい診断基準 (2012)
  • Author(s): 大河内正康
  • Organizer: 第19回近畿老年期認知症研究会
  • Place of Presentation: リーガロイヤルNCB、大阪
  • Invited
• [Presentation] S15-4 認知症バイオマーカーと次世代認知症治療戦略 (2011)
  • Author(s): 大河内正康
  • Organizer: 第21回日本臨床精神神経薬理学会, 第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 第2 会場(コンコード B)シンポジウム 15 認知症の病態理解から診断・治療法へ
  • Year and Date: 2011-10-27
• [Presentation] Biochemistry of "Ab-like Peptide", a novel type of peptide family (2011)
  • Author(s): Masayasu Okochi
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-07-24
• [Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab42 (2011)
  • Author(s): Masayasu Okochi
  • Organizer: AAICAD2011
  • Place of Presentation: Paris Porte de Versailles, Convention and Exhibition Center, France
  • Year and Date: 2011-07-21
• [Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab42 (2011)
  • Author(s): Masayasu Okochi
  • Organizer: AAICAD2011, July 16-21, 2011
  • Place of Presentation: Paris Porte de Versailles, Convention and Exhibition Center Paris, France(招待講演)
  • Year and Date: 2011-07-20
• [Presentation] Session Title: A Return to the Basics- Molecular Decoding of the Alzheimer's Disease Pathogenesis""アルツハイマー病治療薬γセクレターゼ・モジュレーターの理論とその将来的優位性について (2011)
  • Author(s): 大河内正康
  • Organizer: 第33回生物学的精神医学会
  • Place of Presentation: シンポジウム2・アルツハイマー病治療薬の新たな展開 ホテルグランパシフィック LE DAIBA・パレロワイヤル B
  • Year and Date: 2011-05-21
• [Presentation] Aβ様ペプチドの分泌から見えること-Aβ産生過程の発症への関与の可能性 (2010)
  • Author(s): 大河内正康
  • Organizer: 第29回日本認知症学会・シンポジウム 7
  • Place of Presentation: 名古屋ウインク愛知・第2 会場
  • Year and Date: 2010-11-06
• [Presentation] アルツハイマー病Aβとは何か?Aβとよく似た生理ペプチドの発見とその応用についてPractical use of novel physiological peptides produced by beta-and gamma-secretases. (2010)
  • Author(s): 大河内正康
  • Organizer: つくばブレインサイエンスセミナー(TBSA)講演会
  • Place of Presentation: 筑波大学付属病院講堂
  • Year and Date: 2010-09-21
• [Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease (2010)
  • Author(s): Okochi M, Tagami S, Yanagida K, Takeda M
  • Organizer: Alzheimer's Association International Conference o Alzheimer's Disease 2010
  • Place of Presentation: Honolulu Hawaii U.S.A
  • Year and Date: 2010-07-15
• [Presentation] New aspects of pathophysiology and therapeutic/diagnostic strategy of dementia The ratio of CSF APL1beta28, a surrogate marker for Abeta42 (2010)
  • Author(s): Masa Okochi
  • Organizer: increases before onset of sporadic Alzheimer diseaseICAD2010
  • Place of Presentation: Hawaii Convention Center,Honolulu, Hawaii. Oral session
  • Year and Date: 2010-07-14
• [Presentation] Abeta全体を産生する仕組みはアルツハイマー病で加速されているか?-患者CSFを用いた解析 (2010)
  • Author(s): 大河内正康, 田上真次, 柳田寛太, 池内健, 秋山治彦, 徳田隆彦, 武田雅俊
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋市ウインク愛知
• [Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta 28について (2010)
  • Author(s): 田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
  • Organizer: 日本ヒトプロテオーム機構第8回大会
  • Place of Presentation: 東京ベイホテル東急
• [Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients (2010)
  • Author(s): Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
  • Organizer: 第53回日本神経化学会(神戸)大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] Levels of the surrogate marker for Abeta42(i.e., APL1beta)in CSF of sporadic Alzheimer disease patients increase before the onset of its clinical symptoms (2010)
  • Author(s): Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Takeda M
  • Organizer: 第53回日本神経化学会(神戸)大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] Determination of Amino acid sequences of several thousand peptides in human cerebrospinal fluid (2010)
  • Author(s): Kodama S, Okochi M, Tagami S, Yanagida K, Nakayama T, Tatsumi S, Mori K, Takeda M
  • Organizer: 第53回日本神経化学会(神戸)大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
• [Book] 日本発Aβ42サロゲートマーカーの発見と性質 ― アルツハイマー病の発症前診断マーカーへの応用の可能性 (2013)
  • Author(s): 大河内正康
  • Total Pages: 10
  • Publisher: 精神神経学雑誌
• [Book] アミロイドカスケードの異常を反映するAβ42サロゲートマーカーAPL1β28 (2013)
  • Author(s): 大河内正康
  • Total Pages: 10
  • Publisher: 老年精神医学
• [Book] アルツハイマー病薬開発の現状 (2012)
  • Author(s): 大河内正康
  • Total Pages: 10
  • Publisher: 脳21
• [Book] アルツハイマー病バイオマーカーについて (2012)
  • Author(s): 大河内正康
  • Total Pages: 10
  • Publisher: 脳21
• [Book] 認知症学-その解明と治療の最新知見III.臨床編認知症の症候学各論 (2011)
  • Author(s): 大河内正康, 武田雅俊
  • Publisher: (株)日本臨牀社
• [Book] 今、開発されている認知症(アルツハイマー病)の根本治療薬は? (2010)
  • Author(s): 大河内正康
  • Publisher: 日本医事新報社
• [Book] アルツハイマー病Abeta42のサロゲートマーカーAPL1beta28ペプチドの発見:孤発性アルツハイマー病患者脳でAbeta42の産生増大が起こっている可能性について (2010)
  • Author(s): 大河内正康、田上真次、柳田寛太、武田雅俊
  • Publisher: 日本神経精神薬理学雑誌
• [Book] アルツハイマー病老人班に蓄積するAbeta42産生の仕組みはどこまでわかったか?また、その成果の臨床応用の可能性について (2010)
  • Author(s): 大河内正康、武田雅俊
  • Publisher: 金芳堂脳21
• [Book] プレセニリン研究の過去と現在 (2010)
  • Author(s): 大河内正康、武田雅俊
  • Publisher: 老年精神医学雑誌
• [Book] 新規脳内ペプチドAPL1beta28の測定結果からアルツハイマー病をみる (2010)
  • Author(s): 大河内正康、田上真次、柳田寛太、武田雅俊
  • Publisher: メディカルレビュー社 Pharma Medica
• [Book] 中核症状と周辺症状-アルツハイマー病アップデート (2010)
  • Author(s): 大河内正康、武田雅俊
  • Publisher: 中外医学社 Clinical Neuroscience
• [Remarks]
  • URL: http://www.osaka-u.ac.jp/en/research/annual-report/volume-4/graphics/24.html
• [Remarks]
  • URL: http://www.osaka-u.ac.jp/en/research/annual-report/volume-9/100_select_paper/biology02.html
• [Remarks]
  • URL: http://www.osaka-u.ac.jp/en/research/annual-report/volume-11/100_select_paper/copy6_of_science02.html
• [Patent(Industrial Property Rights)] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法 (2010)
  • Inventor(s): 大河内正康、田上真次、武田雅俊、西冨晃平
  • Industrial Property Rights Holder: 大河内正康、田上真次、武田雅俊、西冨晃平
  • Filing Date: 2010-10-18
  • Overseas