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A study on association between sleep structure and conversion to Alzheimer's disease in patients with mild cognitive impairment

Research Project

Project/Area Number 22591286
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKagawa University

Principal Investigator

SHINNO Hideto  香川大学, 医学部, 寄附講座教員 (10393430)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Keywords軽度認知障害 / アルツハイマー病 / 睡眠ポリグラフ検査 / レム睡眠 / 移行ハイリスク / 徐波睡眠 / 周期性四肢運動障害 / レビー小体病
Outline of Final Research Achievements

The aim of this study was to elucidate the properties of sleep architecture in mild cognitive impairment (MCI) and to investigate whether any polysomnography (PSG) variables support the prediction of progression from MCI to Alzheimer’s disease (AD). MCI (24 cases) were enrolled in this study. Clinical evaluation and PSG were carried out at the baseline. PSG demonstrated that sleep architecture in MCI was intermediate state of that between AD and age-matched control. After a 2-year follow-up, subjects were divided into 2 groups. The MCI-AD group included subjects who progressed to AD, and the MCI-MCI group included those who did not meet the criteria for dementia. Basal PSG variables were compared between the groups. Subjects in the MCI-AD group (6 cases) showed a shorter stage REM sleep, and a reduced REM density at the baseline. We consider that these properties may be associated with a higher risk of progression from MCI to AD.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (37 results)

All 2015 2014 2013 2012 2011 2010

All Journal Article (17 results) (of which Peer Reviewed: 8 results) Presentation (17 results) Book (3 results)

  • [Journal Article] レストレス・レッグス症候群の漢方治療2015

    • Author(s)
      新野 秀人
    • Journal Title

      漢方と最新治療

      Volume: 24 Pages: 53-58

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 高齢者の睡眠障害の特徴2015

    • Author(s)
      新野 秀人
    • Journal Title

      日本臨床

      Volume: 73 Pages: 892-894

    • Related Report
      2014 Annual Research Report
  • [Journal Article] リエゾンと緩和。がん患者での睡眠障害の病態(2)2014

    • Author(s)
      新野 秀人
    • Journal Title

      精神科

      Volume: 24 Pages: 212-215

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 緩和ケアにおける睡眠医学2014

    • Author(s)
      新野 秀人
    • Journal Title

      総合病院精神医学

      Volume: 26 Pages: 287-290

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者での睡眠障害の薬物療法2014

    • Author(s)
      新野 秀人
    • Journal Title

      睡眠医療

      Volume: 8 Pages: 700-702

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 睡眠構造の相違からみた代表的認知症の鑑別2013

    • Author(s)
      新野 秀人
    • Journal Title

      睡眠医療

      Volume: 7 Pages: 337-341

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 知っておきたい高齢者の睡眠障害:専門医への紹介が必要な場合2013

    • Author(s)
      新野 秀人
    • Journal Title

      Geriatric Medicine (老年医学)

      Volume: 51 Pages: 1199-1201

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 睡眠薬の適正使用に関するエビデンス抽出と今後の検討課題に関する研究2013

    • Author(s)
      新野 秀人
    • Journal Title

      睡眠薬の適正使用及び減量・中止のための診療ガイドラインに関する研究

      Volume: 平成24年度総括・分担研究報告書 Pages: 69-74

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A patient with type II citrullinemia who developed refractory complex seizure. Gen Hosp Psychiatry.2013

    • Author(s)
      Sakamoto S, Nakamura Y, et al.
    • Journal Title

      Disease Patients. Dement Geriatr Cogn Dis Extra.

      Volume: 35(1) Issue: 1 Pages: 103-103

    • DOI

      10.1016/j.genhosppsych.2012.03.019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 老年期精神障害の不眠2012

    • Author(s)
      新野 秀人
    • Journal Title

      精神科治療学

      Volume: 27(9) Pages: 1161-1165

    • Related Report
      2012 Annual Research Report
  • [Journal Article] がん患者での睡眠障害の病態2012

    • Author(s)
      新野 秀人
    • Journal Title

      精神科

      Volume: 21(6) Pages: 716-720

    • Related Report
      2012 Annual Research Report
  • [Journal Article] A patient with type II citrullinemia who developed refractory generalized seizure2012

    • Author(s)
      Sakamoto S, Shinno H, et al
    • Journal Title

      General Hospital Psychiatry

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia2011

    • Author(s)
      Hideto Shinno, Ichiro Ishikawa, Mami Yamanaka, Ai Usui, Sonoko Danjo, Yasushi Inami, Jun Horiguchi, Yu Nakamura
    • Journal Title

      Sleep Medicine

      Volume: Vol.12 Issue: 6 Pages: 578-583

    • DOI

      10.1016/j.sleep.2011.02.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia2011

    • Author(s)
      Shinno H
    • Journal Title

      Sleep medicine

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proposed dose equivalence between clonazepam and pramipexole in patients with restless legs syndrome.2010

    • Author(s)
      Shinno H
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 34(3) Pages: 522-526

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of restless legs syndrome with herbal prescription Yokukansan.2010

    • Author(s)
      Shinno H
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 34(1) Pages: 252-253

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three patients with cancer who developed rapid eye movement sleep behavior disorder.2010

    • Author(s)
      Shinno H
    • Journal Title

      Journal of Pain and Symptom Management

      Volume: 40(3) Pages: 449-452

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 当院の緩和ケアにおける抗うつ薬の使用経験2014

    • Author(s)
      石川一朗、新野秀人、熊宏美、上野美幸、中條浩介、中村祐
    • Organizer
      第11回日本うつ病学会
    • Place of Presentation
      広島市
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] デュロキセチンへの変更により改善したうつ病患者でのアクチグラムによる検討2014

    • Author(s)
      石川一朗、新野秀人、樋笠直哉、野口勝宏、中村祐
    • Organizer
      第11回日本うつ病学会
    • Place of Presentation
      広島市
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of polysomnography variables on the prediction of conversion from mild cognitive impairment to Alzheimer’s disease2014

    • Author(s)
      Shinno H, Ishikawa I, Ando N, Nakamura Y
    • Organizer
      FENS2014. 9th FENS Forum of Neuroscience
    • Place of Presentation
      Milan
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] アルツハイマー型認知症患者でみられる睡眠構造にメマンチンが及ぼす効果について2013

    • Author(s)
      石川一朗、新野秀人
    • Organizer
      第28回日本老年精神医学会総会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高齢患者への不眠対策2013

    • Author(s)
      新野 秀人
    • Organizer
      日本睡眠学会第38回定期学術集会、シンポジウム
    • Place of Presentation
      秋田市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Memantine improves fragmentation of sleep in patients with Alzheimer’s disease but not Dementia with Lewy bodies.2013

    • Author(s)
      Ichiro Ishikawa, Hideto Shinno
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] アルツハイマー型認知症とレビー小体型認知症患者の睡眠にメマンチンが及ぼす影響について2013

    • Author(s)
      石川一朗、新野秀人
    • Organizer
      第54回中国四国精神神経学会
    • Place of Presentation
      高松市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effect of herbal medicine on restless legs syndrome and comorbid anxiety symptoms2012

    • Author(s)
      Hideto Shinno
    • Organizer
      Sleep 2012 (American Academy of Sleep Medicine)
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] レストレスレッグス症候群と不安症状2012

    • Author(s)
      新野 秀人
    • Organizer
      日本睡眠学会第37回定期学術総会(シンポジウム)
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 認知症患者でみられる睡眠障害にメマンチンが及ぼす効果について2012

    • Author(s)
      石川一朗
    • Organizer
      日本睡眠学会第37回定期学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 認知症と睡眠障害2012

    • Author(s)
      新野 秀人
    • Organizer
      日本睡眠学会第37回定期学術総会(シンポジウム)
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Are any polysomnography variables predictive of progression from mild cognitive impairment to Alzheimer’s disease?2012

    • Author(s)
      Hideto Shinno
    • Organizer
      Neuroscience 2012 (Society for Neuroscience)
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Assessment of sleep architecture in subjects with mild cognitive impairment2011

    • Author(s)
      Shinno H, et al
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington, DC.USA
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Strategy for treatment of REM sleep behavior disorder2011

    • Author(s)
      Shinno H
    • Organizer
      The 5^<th> International RBD Symposium
    • Place of Presentation
      Otsu(招待)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comparison of sleep architecture among Alzheimer's disease, dementia with Lewy bodies and mild cognitive impairments2011

    • Author(s)
      Shinno H, et al
    • Organizer
      World Sleep 2011
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Levothyroxine improves prolonged nocturnal sleep and excessive daytime som.nolence in patients with idiopathic hypersomnia2010

    • Author(s)
      Shinno H
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Herbal medicine for psychiatric symptoms and sleep disturbances inpatients with dementia2010

    • Author(s)
      Shinno H
    • Organizer
      The XXVII Congress of the International College of Neuropsychopharmacology
    • Place of Presentation
      Hong Kong(中国)(招待講演)
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Book] 睡眠薬の適正使用・休薬ガイドライン2014

    • Author(s)
      新野 秀人
    • Total Pages
      220
    • Publisher
      じほう
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Book] 今日の治療指針2014

    • Author(s)
      新野 秀人
    • Total Pages
      2096
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] Sleepiness.Causes, Consequences and Treatment. Chapter "Hypothyroidism and other endocrine causes of sleepiness."2011

    • Author(s)
      Shinno H
    • Publisher
      Cambridge University Press
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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