Neuropathological studyof behavioral and psychological symptoms of dementia

• Project/Area Number: 22591292
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Yokohama City University
• Principal Investigator: TOGO Takashi 横浜市立大学, 医学研究科, 客員准教授 (20381501)
• Co-Investigator(Renkei-kenkyūsha): ISEKI Eizo 順天堂大学, 医学部, 教授 (30203061)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 認知症 / 変性性認知症 / 精神症状 / 行動障害 / 神経症状

Research Abstract

We investigated the pathological background of behavioral and psychological symptoms of dementia. In particular, we investigated localization of FUS in human brains.The dendritic localization of FUS and its increase in FTLD-TDP may have some implication for the pathophysiology of neurodegenerative diseases.

Research Products

• [Journal Article] Anti-glutamate receptor ɛ2 antibodies in psychiatric patients with anti-thyroid autoantibodies--a prevalence study in Japan. (2013)
  • Author(s): Chiba Y
  • Journal Title: Neurosci Lett Volume: 534 Pages: 217-222
  • DOI: 10.1016/j.neulet.2012.10.060
  • Peer Reviewed
• [Journal Article] Localization of fused in sarcoma(FUS) protein to the post synaptic density in the brain (2012)
  • Author(s): Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Katsuse O, Togo T, Hirayasu Y, Akiyama H
  • Journal Title: Acta Neuropathol Volume: (in press) Issue: 3 Pages: 383-94
  • DOI: 10.1007/s00401-012-0984-6
  • Peer Reviewed
• [Journal Article] Progressive nonfluent aphasia : A rare clinical subtype of FTLD-TDP in Japan (2012)
  • Author(s): Aoki N, Tsuchiya K, Kobayashi Z, Arai T, Togo T, Miyazaki H, Kondo H, Ishizu H, Uchikado H, Katsuse O, Hirayasu Y, Akiyama H
  • Journal Title: Neuropathology Volume: (in press) Issue: 3 Pages: 272-9
  • DOI: 10.1111/j.1440-1789.2011.01253.x
  • Peer Reviewed
• [Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies (2012)
  • Author(s): Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H
  • Journal Title: J Neurol Sci. Volume: 314(1-2) Issue: 1-2 Pages: 111-9
  • DOI: 10.1016/j.jns.2011.10.010
  • Peer Reviewed
• [Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies (2012)
  • Author(s): Kasanuki K, Togo T, et al
  • Journal Title: J Neurol Sci Volume: 314 Pages: 111-119
  • Peer Reviewed
• [Journal Article] Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain (2012)
  • Author(s): Aoki N, Togo T, et al
  • Journal Title: Acta Neuropathol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies. (2011)
  • Author(s): Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H, Wada K, Iseki E
  • Journal Title: J Neuropathol Exp Neurol Volume: 70(4) Issue: 4 Pages: 264-80
  • DOI: 10.1097/nen.0b013e318211c86a
  • Peer Reviewed
• [Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy ca (2011)
  • Author(s): Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Anno M, Kosaka K, Akiyama H, Hirayasu Y
  • Journal Title: Neuropathology Volume: 31 Issue: 2 Pages: 135-143
  • DOI: 10.1111/j.1440-1789.2010.01152.x
  • Peer Reviewed
• [Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy cases. (2011)
  • Author(s): Aoki N, Togo T, et al.
  • Journal Title: Neuropathology Volume: 31 Pages: 135-143
  • Peer Reviewed
• [Journal Article] Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia (2010)
  • Author(s): Fujishiro H, Iseki E, Higashi S, Kasanuki K, Murayama N,Togo T, Katsuse O, Uchikado H, Aoki N, Kosaka K, Arai H, Sato K
  • Journal Title: Neurosci Lett Volume: 486(1) Issue: 1 Pages: 19-23
  • DOI: 10.1016/j.neulet.2010.09.036
  • Peer Reviewed
• [Journal Article] GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation (2010)
  • Author(s): Higashi S, Iseki E, Minegishi M,Togo T, Kabuta T, Wada K
  • Journal Title: J Neurochem Volume: 115(2) Issue: 2 Pages: 423-37
  • DOI: 10.1111/j.1471-4159.2010.06930.x
  • Peer Reviewed
• [Journal Article] Administration of zonisamide in three cases of dementia with Lewy bodies. (2010)
  • Author(s): Odawara T, Togo T, et al.
  • Journal Title: Psychiatry Clin Neurosci Volume: 64号 Pages: 327-329
  • Peer Reviewed
• [Journal Article] Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia. (2010)
  • Author(s): Fujishiro H, Togo T, et al.
  • Journal Title: Neurosci Lett Volume: 486 Pages: 19-23
  • Peer Reviewed
• [Presentation] Fahr病の2剖検例:老人性病理を欠く47歳家族性石灰化症例とアルツハイマーおよびレビー病理を伴う80歳孤発例. (2012)
  • Author(s): 笠貫浩史、都甲崇
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟コンベンションセンター(新潟)
  • Year and Date: 2012-06-28
• [Presentation] 進行性失語が前景に立った運動ニューロン疾患を伴う前頭側頭型認知症の二剖検例 (2012)
  • Author(s): 河上緒、都甲崇
  • Organizer: 第53回日本神経病理学会
  • Place of Presentation: 新潟コンベンションセンター(新潟)
  • Year and Date: 2012-06-28
• [Presentation] レビー小体型認知症脳における18F-FDG PETの糖代謝低下部位の神経病理学的検討 (2011)
  • Author(s): 笠貫浩史、都甲崇
  • Organizer: 第52回日本神経病理学会
  • Place of Presentation: 京都テルサ(京都)
  • Year and Date: 2011-06-02
• [Presentation] レビー小体型認知症のアミロイドアンギオパチーに関する神経病理学的検討 (2011)
  • Author(s): 藤城弘樹、都甲崇
  • Organizer: 第52回日本神経病理学会
  • Place of Presentation: 京都テルサ(京都)
  • Year and Date: 2011-06-02
• [Presentation] ニューロピルに認められるFUS陽性微細顆粒について (2011)
  • Author(s): 青木直哉、都甲崇
  • Organizer: 第52回日本神経病理学会
  • Place of Presentation: 京都テルサ(京都)
  • Year and Date: 2011-06-02
• [Presentation] 進行性非流暢性失語を呈したTDP-43陽性封入体を伴う前頭側頭葉変性症の1例 (2010)
  • Author(s): 青木直哉、都甲崇
  • Organizer: 第97回日本神経病理学会関東地方会
  • Place of Presentation: 順天堂大学医学部組織実習室(東京)
  • Year and Date: 2010-12-04
• [Presentation] Administration of Zonisamide in four cases of dementia with Lewy bodies. (2010)
  • Author(s): Odawara T, Togo T, et al.
  • Organizer: IPA 2010International Meeting
  • Place of Presentation: Santiago de Compostela, Spain
  • Year and Date: 2010-09-27
• [Book] もの忘れと認知症 (2010)
  • Author(s): 都甲崇、内門大丈、勝瀬大海、青木直哉
  • Publisher: みすず書房
• [Book] もの忘れと認知症 (2010)
  • Author(s): 都甲崇(監訳)
  • Total Pages: 280
  • Publisher: みすず書房