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Neuropathological studyof behavioral and psychological symptoms of dementia

Research Project

Project/Area Number 22591292
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionYokohama City University

Principal Investigator

TOGO Takashi  横浜市立大学, 医学研究科, 客員准教授 (20381501)

Co-Investigator(Renkei-kenkyūsha) ISEKI Eizo  順天堂大学, 医学部, 教授 (30203061)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords認知症 / 変性性認知症 / 精神症状 / 行動障害 / 神経症状
Research Abstract

We investigated the pathological background of behavioral and psychological symptoms of dementia. In particular, we investigated localization of FUS in human brains.The dendritic localization of FUS and its increase in FTLD-TDP may have some implication for the pathophysiology of neurodegenerative diseases.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Anti-glutamate receptor ɛ2 antibodies in psychiatric patients with anti-thyroid autoantibodies--a prevalence study in Japan.2013

    • Author(s)
      Chiba Y
    • Journal Title

      Neurosci Lett

      Volume: 534 Pages: 217-222

    • DOI

      10.1016/j.neulet.2012.10.060

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of fused in sarcoma(FUS) protein to the post synaptic density in the brain2012

    • Author(s)
      Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Katsuse O, Togo T, Hirayasu Y, Akiyama H
    • Journal Title

      Acta Neuropathol

      Volume: (in press) Issue: 3 Pages: 383-94

    • DOI

      10.1007/s00401-012-0984-6

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Progressive nonfluent aphasia : A rare clinical subtype of FTLD-TDP in Japan2012

    • Author(s)
      Aoki N, Tsuchiya K, Kobayashi Z, Arai T, Togo T, Miyazaki H, Kondo H, Ishizu H, Uchikado H, Katsuse O, Hirayasu Y, Akiyama H
    • Journal Title

      Neuropathology

      Volume: (in press) Issue: 3 Pages: 272-9

    • DOI

      10.1111/j.1440-1789.2011.01253.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies2012

    • Author(s)
      Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H
    • Journal Title

      J Neurol Sci.

      Volume: 314(1-2) Issue: 1-2 Pages: 111-9

    • DOI

      10.1016/j.jns.2011.10.010

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies2012

    • Author(s)
      Kasanuki K, Togo T, et al
    • Journal Title

      J Neurol Sci

      Volume: 314 Pages: 111-119

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain2012

    • Author(s)
      Aoki N, Togo T, et al
    • Journal Title

      Acta Neuropathol

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.2011

    • Author(s)
      Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H, Wada K, Iseki E
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 70(4) Issue: 4 Pages: 264-80

    • DOI

      10.1097/nen.0b013e318211c86a

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy ca2011

    • Author(s)
      Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Anno M, Kosaka K, Akiyama H, Hirayasu Y
    • Journal Title

      Neuropathology

      Volume: 31 Issue: 2 Pages: 135-143

    • DOI

      10.1111/j.1440-1789.2010.01152.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy cases.2011

    • Author(s)
      Aoki N, Togo T, et al.
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 135-143

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia2010

    • Author(s)
      Fujishiro H, Iseki E, Higashi S, Kasanuki K, Murayama N,Togo T, Katsuse O, Uchikado H, Aoki N, Kosaka K, Arai H, Sato K
    • Journal Title

      Neurosci Lett

      Volume: 486(1) Issue: 1 Pages: 19-23

    • DOI

      10.1016/j.neulet.2010.09.036

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation2010

    • Author(s)
      Higashi S, Iseki E, Minegishi M,Togo T, Kabuta T, Wada K
    • Journal Title

      J Neurochem

      Volume: 115(2) Issue: 2 Pages: 423-37

    • DOI

      10.1111/j.1471-4159.2010.06930.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Administration of zonisamide in three cases of dementia with Lewy bodies.2010

    • Author(s)
      Odawara T, Togo T, et al.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64号 Pages: 327-329

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia.2010

    • Author(s)
      Fujishiro H, Togo T, et al.
    • Journal Title

      Neurosci Lett

      Volume: 486 Pages: 19-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Fahr病の2剖検例:老人性病理を欠く47歳家族性石灰化症例とアルツハイマーおよびレビー病理を伴う80歳孤発例.2012

    • Author(s)
      笠貫浩史、都甲崇
    • Organizer
      第53回日本神経病理学会
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 進行性失語が前景に立った運動ニューロン疾患を伴う前頭側頭型認知症の二剖検例2012

    • Author(s)
      河上緒、都甲崇
    • Organizer
      第53回日本神経病理学会
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Year and Date
      2012-06-28
    • Related Report
      2012 Final Research Report
  • [Presentation] レビー小体型認知症脳における18F-FDG PETの糖代謝低下部位の神経病理学的検討2011

    • Author(s)
      笠貫浩史、都甲崇
    • Organizer
      第52回日本神経病理学会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] レビー小体型認知症のアミロイドアンギオパチーに関する神経病理学的検討2011

    • Author(s)
      藤城弘樹、都甲崇
    • Organizer
      第52回日本神経病理学会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] ニューロピルに認められるFUS陽性微細顆粒について2011

    • Author(s)
      青木直哉、都甲崇
    • Organizer
      第52回日本神経病理学会
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 進行性非流暢性失語を呈したTDP-43陽性封入体を伴う前頭側頭葉変性症の1例2010

    • Author(s)
      青木直哉、都甲崇
    • Organizer
      第97回日本神経病理学会関東地方会
    • Place of Presentation
      順天堂大学医学部組織実習室(東京)
    • Year and Date
      2010-12-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Administration of Zonisamide in four cases of dementia with Lewy bodies.2010

    • Author(s)
      Odawara T, Togo T, et al.
    • Organizer
      IPA 2010International Meeting
    • Place of Presentation
      Santiago de Compostela, Spain
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Book] もの忘れと認知症2010

    • Author(s)
      都甲崇、内門大丈、勝瀬大海、青木直哉
    • Publisher
      みすず書房
    • Related Report
      2012 Final Research Report
  • [Book] もの忘れと認知症2010

    • Author(s)
      都甲崇(監訳)
    • Total Pages
      280
    • Publisher
      みすず書房
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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