| Project/Area Number |
22591297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Juntendo University |
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Principal Investigator |
INAMI Rie 順天堂大学, 医学部, 准教授 (50338331)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 統合失調症 / unctional MRI / mismatch negativity / functional MRI / Mismatch Negativity / Mismatch negativity / sensory memory / 事象関連電位 / event-related potentials / Schizophrenia |
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| Research Abstract |
Significant correlations were obtained among data of each recording modality and clinical manifestations, i.e. EEG, fMRI, and PANSS. These correlations support that the BOLD activation obtained in the present fMRI experiment reflects equivalent physiological mechanism of MMN generation recorded via ERP methods.The correlation analysis on SPM revealed significant correlation between BOLD activity of the right anterior cingulate, the right corpus callosum and right insula and PANSS scores of general, negative, and positive symptoms respectively.The dysfunction of Insula, the uncinate fasciculus and the corpus callosum, as well as the temporal lobe and the anterior cingulate gyrus, may specifically contribute to MMN aberration of schizophrenic patients and clinical manifestations reflecting their impaired MMN generation.Observed positive correlation between BOLD activities and PANSS scores may reflect hypersensitivity or distractibility of schizophrenic patients.
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