Effect of ECT on the brain dopaminergic receptor.

• Project/Area Number: 22591302
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokyo National University of Fine Arts and Music (2011-2012); Nippon Medical School (2010)
• Principal Investigator: SAIJO Tomoyuki 東京芸術大学, 大学院・映像研究科, 非常勤講師 (50373014)
• Co-Investigator(Kenkyū-buntansha): OKUBO Yoshiro 日本医科大学, 医学研究科, 教授 (20213663) ; ICHIMIYA Tetsuya 日本医科大学, 医学部, 講師 (50398864)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 電気けいれん療法 / 難治性うつ病 / PET

Research Abstract

Using PET with [11^C]raclopride, we evaluated the effect of ECT on D2DR binding in patients with major depressive disorder (MDD). Two patients with MDD underwent PET scans before and after ECT. All patients showed clinical improvements in response to ECT. Binding potentials were increased in both side of the striatum by ECT . These findings might be related to the effect of ECT on D2DR. However those changes are not statistically significant due to a lack of statistical power. Further studies will be needed.

Research Products

• [Presentation] PETによるECTの作用機序の研究 (2010)
  • Author(s): 西條朋行
  • Organizer: 第23回日本総合病院精神医学会総会
  • Place of Presentation: 都市センターホテル
  • Year and Date: 2010-11-27