| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The role of dopamine and noradrenalin among the patients with depression were evaluated by neuromelanin magnetic resonance imaging (MRI) and dopamine transporter (DAT) positron emission tomography (PET). The signal of neuromelanin MRI of patients with depression was significantly lower in locus coeruleus and substantia nigra pars compacta than healthy controls. The availability of dopamine transporter in striatum of patients with depressed phase was significantly lower than healthy controls, however that of patients with remitted phase was comparable with healthy controls. The signal of neuromelanin MRI was significantly correlated with the function of dopamine transporter among healthy controls. In conclusion, patients with depression had lower dopaminergic function and neulomelanin MRI was as useful as DAT PET for the evaluation of dopaminergic function.
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