A pharmaco-EEG study in patients with schizophrenia

• Project/Area Number: 22591305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kansai Medical University
• Principal Investigator: YOSHIMURA Masafumi 関西医科大学, 医学部, 講師 (10351553)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Toshihiko 関西医科大学, 医学部, 教授 (20186290) ; NISHIDA Keiichiro 関西医科大学, 医学部, 助教 (40567567)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 統合失調症 / 抗精神病薬 / 定量薬物脳波学 / アリピプラゾール / sLORETA / microstate / functional connectivity / BRL-sLORETA database / 定量脳波学 / 薬物脳波学 / 定量脳波 / 薬物脳波 / aripiprazole / 下頭頂小葉 / 医療・福祉 / 精神医学 / 神経生理学

Outline of Final Research Achievements

We performed a pharmaco-EEG study of antipsychotics in patients with schizophrenia by qEEG analyses. Resting EEG was recorded before and four weeks after treatment with aripiprazole (APZ) in four drug naive patients with schizophrenia. EEG microstates were computed in 2-20Hz in two cases, and compared to microstates which were obtained from controls. Whole cortex electric neuronal activity distribution, and intracortical physiological lagged connectivity between 11 ROIs, were computed in seven frequency bands, using the sLORETA software, and compared to the normative BRL-sLORETA database in four cases.
Deviations at baseline of certain microstate of one case　and cortical activity distribution of three cases tended towards normal values after treatment. In two cases, baseline deviant functional connectivity of delta activity normalized after treatment.
APZ induced changes towards normal in several values. This evidence may give partial support for the effectiveness of the medication.

Research Products

• [Journal Article] 統合失調症患者への抗精神病薬投与が脳内機能的連結に与える変化 (2015)
  • Author(s): 吉村匡史、Pascual-Marqui RD、西田圭一郎、 三井 浩、北浦祐一、嶽北佳輝、 磯谷俊明、木下利彦
  • Journal Title: 日本薬物脳波雑誌 Volume: 16
  • Peer Reviewed
• [Journal Article] 向精神薬の薬物脳波的検討‐sLORETAの正常データベースによる抗精神病薬の少数例予備的検討‐ (2013)
  • Author(s): 吉村匡史、西田圭一郎、嶽北佳輝、高野悟史、三井浩、北浦祐一、加藤正樹、磯谷俊明、Roberto D. Pascual-Marqui、木下利彦
  • Journal Title: 日本薬物脳波学会雑誌 Volume: 14 Pages: 45-49
  • Peer Reviewed
• [Presentation] 統合失調症患者への抗精神病薬投与が脳内機能的連結に与える変化 (2014)
  • Author(s): 吉村匡史、Pascual-Marqui RD、西田圭一郎、 三井 浩、北浦祐一、嶽北佳輝、 磯谷俊明、木下利彦
  • Organizer: 第17回日本薬物脳波学会
  • Place of Presentation: 静岡（長泉山荘）
  • Year and Date: 2014-06-13 – 2014-06-14
• [Presentation] Pharmaco-EEG study (2013)
  • Author(s): Masafumi Yoshimura, Keiichiro Nishida, Roberto Pascual‐Marqui, Hiroshi Mii, Yuichi Kitaura, Yoshiteru Takekita, Toshiaki Isotani, Toshihiko Kinoshita
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto（京都国際会館）
• [Presentation] 統合失調症患者への抗精神病薬投与によるfunctional connectivityの変化 (2013)
  • Author(s): 吉村匡史、パスカル・マルキ ロベルト、西田圭一郎、三井浩、北浦祐一、嶽北佳輝、森村惠介、松田達也、磯谷俊明、木下利彦
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知（ザ・クラウンパレス新阪急高知）
• [Presentation] Pharmaco-EEG study (2013)
  • Author(s): Masafumi Yoshimura
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] 向精神薬の薬物脳波的検討 (2012)
  • Author(s): 吉村匡史
  • Organizer: 第15回日本薬物脳波学会学術集会
  • Place of Presentation: 日本大学会館（東京）
• [Presentation] Functional connectivity in schizophrenic patients who were treated with aripiprazole (2012)
  • Author(s): Masafumi Yoshimura
  • Organizer: IPEG meeting 2012
  • Place of Presentation: New York（アメリカ）
• [Presentation] 統合失調症患者へのaripiprazole投与が脳内電気活動に及ぼす変化‐正常データベースとの比較‐（第2報） (2012)
  • Author(s): 吉村匡史
  • Organizer: 第42回日本臨床神経生理学会学術大会
  • Place of Presentation: 京王プラザホテル（東京）
• [Presentation] 統合失調症患者へのaripiprazole投与が脳内電気活動に与える変化－BRL-sLORETA Normsを用いた薬物脳波学的研究－(A preliminary study) (2011)
  • Author(s): 吉村匡史
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌コンベンションセンター（札幌）
• [Presentation] Investigation of aripiplazole effects in schizophrenic patients using BRL-sLORETA norms:a preliminary study (2011)
  • Author(s): Masafumi Yoshimura
  • Organizer: ISNIP 2011Joint meeting
  • Place of Presentation: Heidelberg(ドイツ）
• [Presentation] 統合失調症患者へのaripiprazole投与が脳内電気活動に及ぼす変化‐正常データベースとの比較‐(A preliminary study) (2011)
  • Author(s): 吉村匡史
  • Organizer: 第41回日本臨床神経生理学会・学術大会
  • Place of Presentation: グランシップ（静岡）
• [Presentation] Evaluation of aripiplazole effects in schizophreniausing BRL-sLORETA norms : a preliminary study (2010)
  • Author(s): Masafumi Yoshimura
  • Organizer: 16th Biennial International Pharmaco-EEG Group(IPEG)Congress
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2010-10-08