Investigation of biological markers for schizophrenia

• Project/Area Number: 22591307
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TOYOTA Tomoko 独立行政法人理化学研究所, 分子精神科学研究チーム, 専門職研究員 (20392045)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Takeo 独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 統合失調症

Research Abstract

The identification for causative genes of schizophrenia remains to be difficult because of the lack of objective, biological indicator on diagnoses, and its ethiological heterogeneity.
This study aimed to investigate prepulse inhibition, one of a biological marker of schizophrenia, in patients and controls. Additionally, we have examined the quality of the genomic DNAs extracted from saliva and collected them to enlarge the sample size in future genetic studies.

Research Products

• [Journal Article] Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history (2011)
  • Author(s): Toyosima M, Maekawa M, Toyota T, Iwayama Y, Arai M, Ichikawa T, Miyashita M, Arinami T, Itokawa M, Yoshikawa T
  • Journal Title: Br J Psychiatry Volume: 199(3) Pages: 245-6
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia in Japanese population (2011)
  • Author(s): Yamada K, Iwayama Y, Hattori E, Iwamoto K, Toyota T, Ohnishi T, Ohba H, Maekawa M, Kato T, Yoshikawa T
  • Journal Title: PLoS One Volume: 6(6)
  • Peer Reviewed
• [Journal Article] Association Study of Nogo-related Genes with Schizophrenia in a Japanese Case-control Sample (2011)
  • Author(s): Jitoku D, Hattori E, Iwayawa Y, Yamada K, Toyota T, Kikuchi M, Maekawa M, Nishikawa T, Yoshika T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 156 Issue: 5 Pages: 581-592
  • DOI: 10.1002/ajmg.b.31199
  • Peer Reviewed
• [Journal Article] Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample (2011)
  • Author(s): Daisuke Jitoku
  • Journal Title: American Journal of Medical Genetics Part B : Neuropsy chiatric Genetics Volume: 156 Issue: 5 Pages: 581-592
  • DOI: 10.1002/ajmg.b.31195
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia in Japanese population (2011)
  • Author(s): Kazuo Yamada
  • Journal Title: PLoS One Volume: 6 Issue: 6 Pages: e20468-e20468
  • DOI: 10.1371/journal.pone.0020468
  • Peer Reviewed
• [Journal Article] Schizophrenia with the 22q11.2 deletion and additional genetic defects : case history (2011)
  • Author(s): Manabu Toyoshima
  • Journal Title: The British Journal of Psychiatry Volume: 199 Issue: 3 Pages: 245-246
  • DOI: 10.1192/bjp.bp.111.093849
  • Peer Reviewed
• [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis (2010)
  • Author(s): Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, akamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 153B(6) Pages: 1221-7
  • Peer Reviewed
• [Journal Article] Enhanced carbonyl stress in a subpopulation of schizophrenia (2010)
  • Author(s): Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M
  • Journal Title: Arch Gen Psychiatry Volume: 67(6) Pages: 589-97
  • Peer Reviewed
• [Journal Article] Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder (2010)
  • Author(s): Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, ikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 153B(2) Pages: 484-93
  • Peer Reviewed
• [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis. (2010)
  • Author(s): Yasuhide Iwata
  • Journal Title: American Journal of Medical Genetics Part B : Neuropsychiatric Genetics Volume: 153 Pages: 1221-1227
  • Peer Reviewed
• [Journal Article] Enhanced carbonyl stress in a subpopulation of schizophrenia. (2010)
  • Author(s): Makoto Arai
  • Journal Title: Archives of General Psychiatry. Volume: 67 Pages: 589-597
  • Peer Reviewed
• [Journal Article] Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. (2010)
  • Author(s): Yoshimi Iwayama
  • Journal Title: American Journal of Medical Genetics Part B : Neuropsychiatric Genetics Volume: 153 Pages: 484-493
  • Peer Reviewed