Investigation of biological markers for schizophrenia
| Project/Area Number |
22591307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TOYOTA Tomoko 独立行政法人理化学研究所, 分子精神科学研究チーム, 専門職研究員 (20392045)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Takeo 独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 統合失調症 |
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| Research Abstract |
The identification for causative genes of schizophrenia remains to be difficult because of the lack of objective, biological indicator on diagnoses, and its ethiological heterogeneity.
This study aimed to investigate prepulse inhibition, one of a biological marker of schizophrenia, in patients and controls. Additionally, we have examined the quality of the genomic DNAs extracted from saliva and collected them to enlarge the sample size in future genetic studies.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis2010
Author(s)
Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, akamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 153B(6)
Pages: 1221-7
Related Report
Peer Reviewed
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[Journal Article] Enhanced carbonyl stress in a subpopulation of schizophrenia2010
Author(s)
Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M
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Journal Title
Arch Gen Psychiatry
Volume: 67(6)
Pages: 589-97
Related Report
Peer Reviewed
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[Journal Article] Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder2010
Author(s)
Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, ikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 153B(2)
Pages: 484-93
Related Report
Peer Reviewed
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