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Functional analysis of DC brain potential and its application in psychiatry

Research Project

Project/Area Number 22591308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

SHINBA Toshikazu  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 (80175398)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsDC電位 / 覚醒 / 注意 / 意欲 / ラット / 精神疾患 / slow potential / 不安障害 / うつ病 / ヒト / CNV / マウス / 意識 / ストレス
Research Abstract

The present study investigated the function of slow electrical event in the brain including direct current (DC) potential and slow potential (SP) with respect to arousal using the data from animal and psychiatric experiments.
The results have indicated that DC level fluctuates in response to arousal changes in relation to psychological and motor function, including movement, attention and motivation. It is suggested that DC potential can be a parameter of arousal condition, in addition to neuronal firing and AC potential, to eletrophysiologically understand the brain function.
Furthermore, DC stimulation altered the auditory evoked potential and heart-rate variability indices, indicating the usefulness of DC potential in psychiatric practice.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2014 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results)

  • [Journal Article] Altered autonomic activity and reactivity in depression revealed by heart-rate variability measurement during rest and task conditions2014

    • Author(s)
      Shinba T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68 Pages: 225-233

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Psychiatric symptoms of noradrenergic dysfunction : A pathophysiological view2014

    • Author(s)
      Yamamoto K, Shinba T, Yoshii M
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68 Pages: 1-20

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Psychiatric symptoms of noradrenergic dysfunction: a pathophysiological view2014

    • Author(s)
      Yamamoto K, Shinba T, Yoshii M
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 68 Issue: 1 Pages: 1-20

    • DOI

      10.1111/pcn.12126

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性疼痛に対する電界治療の有効性:明確な基礎疾患を有しない症例におけるパイロットスタディ2012

    • Author(s)
      榛葉俊一、高橋国人、兼高里美、根立隆樹、山根木正人、道解冬樹、堀卓也、原川信二、三木正晴、原浩之、鈴木宏志、原昭邦
    • Journal Title

      日本統合医療学会誌

      Volume: 5 Pages: 68-72

    • NAID

      40019307727

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 慢性疼痛に対する電界治療の有効性: 明確な基礎疾患を有しない症例におけるパイロットスタディ2012

    • Author(s)
      榛葉俊一
    • Journal Title

      日本統合医療学会誌

      Volume: 5 Pages: 68-72

    • NAID

      40019307727

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delayed increase of brain noradrenaline after acute footshock stress in rats2010

    • Author(s)
      Shinba T, Ozawa N, Yoshii M, Yamamoto K
    • Journal Title

      Neurochemical Research

      Volume: 35 Pages: 412-417

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 意欲と皮質DC電位との関連:脳内自己刺激を用いた電気生理学的研究2011

    • Author(s)
      榛葉俊一、高橋幸利、堀米ゆみ、星詳子
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Motivation and cortical DC potential shift : An electrophysioloical study using intracranial self-stimulation in rats2011

    • Author(s)
      葉俊一、高橋幸利、堀米ゆみ、星詳
    • Organizer
      第34回日本神経科学学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 24-hour fluctuation of DC brain potential in rats2010

    • Author(s)
      榛葉俊一、星詳子
    • Organizer
      第33回日本神経科学学会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット脳DC電位の24時間変動2010

    • Author(s)
      榛葉俊一、星詳子
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2013 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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