| Project/Area Number |
22591313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
CHIBA Satoru 北海道大学, 北海道大学病院, 医員 (40553368)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUI Hiroyuki 北海道大学, 大学院・医学研究科, 教授 (70264017)
YOKOSHIKI Hisashi 北海道大学, 北海道大学病院, 講師 (40360911)
YAMADA Satoshi 北海道大学, 北海道大学病院, 講師 (80374320)
YOSHINAGA Keiichirou 北海道大学, 大学院・医学研究科, 教授 (30435961)
KATOU Chietsugu 北海道大学, 保健科学院, 教授 (10292012)
真鍋 徳子 (大山 徳子) 北海道大学, 大学病院, 講師 (70463742)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 酢酸 PET / 心筋酸素代謝 / 心臓再同期療法 / PET / 酢酸PET / 心エコー検査 / 心筋Strain / 心筋局所の仕事量 / 心筋血流シンチ |
|---|
| Research Abstract |
Cardiac resynchronization therapy (CRT) can induce reversing left ventricular (LV) remodeling and improve the abnormalities in the perfusion and metabolism in patients with heart failure (HF). Acetate positron emission tomography (PET) could provide biologic information about the myocardium at both regional and global levels. We test the hypothesis that CRT can decrease LV volume and improve myocardial oxidative metabolism as well as LV volume in HF patients. CRT induced reverse LV remdeling in patients with HF, which was associated with a reduction in heterogenous oxidative metabolism.
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