Optimization of local cerebral cortical thickness measurement and comparison of cortical thickness and cortical volume data

• Project/Area Number: 22591316
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nihon University
• Principal Investigator: ABE Osamu 日本大学, 医学部, 教授 (50302716)
• Co-Investigator(Kenkyū-buntansha): SHIZUKUISHI Takashi 日本大学, 医学部, 助手 (30570741)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 中枢神経 / 皮質厚 / 皮質容積 / ボクセルベース解析

Research Abstract

In this study, we extracted the regional cerebral cortical structural information from 3 dimensional T1-weighted magnetic resonance images using several segmentation algorithms. We compared cortical thickness data with cortical volumes and volumetric loss of brain tissue among the same subject groups in a voxel-wise manner. Although we observed significant regional structural changes in all the methods, spatial distribution with significant changes were different among algorithms, which suggested these methods have different types of information regarding brain structures.

Research Products

• [Journal Article] White Matter Alteration in Metabolic Syndrome: Diffusion Tensor Analysis. (2013)
  • Author(s): Shimoji K
  • Journal Title: Diabetes Care. Volume: 36(3) Issue: 3 Pages: 696-700
  • DOI: 10.2337/dc12-0666
  • Peer Reviewed
• [Journal Article] Absence of age-related prefrontal NAA change in adults with autism spectrum disorders (2013)
  • Author(s): Aoki, Y., Abe, O., Yahata, N., Kuwabara, H., Natsubori, T., Iwashiro, N., Takano, Y., Inoue,H., Kawakubo, Y., Gonoi, W., Sasaki, H., Murakami, M., Katsura, M., Nippashi, Y., Takao, H., Kunimatsu, A., Matsuzaki, H., Tsuchiya, K. J., Kato, N., Kasai, K. & Yamasue, H
  • Journal Title: Transl Psychiatry Volume: 2 Issue: 10 Pages: e178-e178
  • DOI: 10.1038/tp.2012.108
  • Peer Reviewed
• [Journal Article] Bilateral pre- and postcentral gyrus volume positively correlates with t2-snr of putamen in healthy adults (2013)
  • Author(s): Goto M, Abe O, et al
  • Journal Title: Neuroradiology Volume: 55 Issue: 2 Pages: 245-250
  • DOI: 10.1007/s00234-012-1126-5
  • Peer Reviewed
• [Journal Article] Association between iron content and gray matter missegmentation with voxel-based morphometry in basal ganglia. (2013)
  • Author(s): Goto M
  • Journal Title: J Magn Reson Imaging. Volume: 38(4) Issue: 4 Pages: 958-962
  • DOI: 10.1002/jmri.23916
  • Peer Reviewed
• [Journal Article] Effects of age and gender on neuroanatomical volumes. (2013)
  • Author(s): Inano S, Takao H, Hayashi N, Yoshioka N, Mori H, Kunimatsu A, Abe O, et al
  • Journal Title: J Magn Reson Imaging. Volume: in press Issue: 5 Pages: 1072-1076
  • DOI: 10.1002/jmri.23910
  • Peer Reviewed
• [Journal Article] Efficiency of go/no-go task performance implemented in the left hemisphere (2012)
  • Author(s): Hirose S., Chikazoe J., Watanabe T., Jimura K., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
  • Journal Title: Journal of Neuroscience Volume: 32 Issue: 26 Pages: 9059-9065
  • DOI: 10.1523/jneurosci.0540-12.2012
  • Peer Reviewed
• [Journal Article] Effects of image distortion correction on voxel-based morphometry (2012)
  • Author(s): Goto M, Abe O, et al
  • Journal Title: Magn Reson Med Sci. Volume: 11 Pages: 27-34
  • NAID: 10030284763
  • Peer Reviewed
• [Journal Article] Influence of signal intensity non-uniformity on brain volumetry using an atlas-based method. (2012)
  • Author(s): Goto M, Abe O, at al
  • Journal Title: Korean J Radiol. Volume: 13 Issue: 4 Pages: 391-402
  • DOI: 10.3348/kjr.2012.13.4.391
  • Peer Reviewed
• [Journal Article] Repeatability of Measured Brain Volume by Atlas-Based Method Using T1-Weighted Image (2012)
  • Author(s): M.Goto, T.Miyati, O.Abe, et al
  • Journal Title: J Digit Imaging Volume: 25 Issue: 1 Pages: 173-8
  • DOI: 10.1007/s10278-011-9412-z
  • Peer Reviewed
• [Journal Article] Local signal time-series during rest used for areal boundary mapping in individual human brains (2012)
  • Author(s): Hirose S., Watanabe T., Jimura K., Katsura M., Kunimatsu A., Abe O., Ohtomo K., Miyashita Y., Konishi S
  • Journal Title: PLoS ONE Volume: 7 Issue: 5 Pages: e36496-e36496
  • DOI: 10.1371/journal.pone.0036496
  • Peer Reviewed
• [Journal Article] Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia (2012)
  • Author(s): Iwashiro, N., Suga, M., Takano, Y., Inoue, H., Natsubori, T., Satomura, Y., Koike, S., Yahata, N., Murakami, M., Katsura, M., Gonoi, W., Sasaki, H., Takao, H., Abe, O., Kasai, K. & Yamasue, H
  • Journal Title: Schizophr Res Volume: 137(1-3) Issue: 1-3 Pages: 124-31
  • DOI: 10.1016/j.schres.2012.02.024
  • Peer Reviewed
• [Journal Article] White matter alteration of the cingulum in parkinson disease with and without dementia: Evaluation by diffusion tensor tract-specific analysis. (2012)
  • Author(s): Kamagata K, Motoi Y, Abe O, et al
  • Journal Title: AJNR Am J Neuroradiol. Volume: 33 Issue: 5 Pages: 890-895
  • DOI: 10.3174/ajnr.a2860
  • Peer Reviewed
• [Journal Article] Radiological features of igg4-related disease in the head, neck, and brain (2012)
  • Author(s): Katsura M, Mori H, Kunimatsu A, Sasaki H, Abe O, et al
  • Journal Title: Neuroradiology Volume: 54 Issue: 8 Pages: 873-882
  • DOI: 10.1007/s00234-012-1012-1
  • Peer Reviewed
• [Journal Article] Pain intensity and psychosocial characteristics of patients with burning mouth syndrome and trigeminal neuralgia. (2012)
  • Author(s): Komiyama O, Obara R, Uchida T, Nishimura H, Iida T, Okubo M, Shimosaka M, Narita N, Niwa H, Shinoda M, Kobayashi M, Noma N, Abe O, et al
  • Journal Title: J Oral Sci. Volume: 54 Pages: 321-327
  • NAID: 130003318540
  • Peer Reviewed
• [Journal Article] Tract-specific analysis of white matter integrity disruption in schizophrenia (2012)
  • Author(s): Kunimatsu N, Aoki S, Kunimatsu A, Abe O, et al
  • Journal Title: Psychiatry Res. Volume: 201 Issue: 2 Pages: 136-143
  • DOI: 10.1016/j.pscychresns.2011.07.010
  • Peer Reviewed
• [Journal Article] Diminished Medial Prefrontal Activity Behind Autistic Social Judgments of Incongruent Information. (2012)
  • Author(s): 渡部喬光
  • Journal Title: PLoS One Volume: 7 Issue: 6 Pages: e39561-e39561
  • DOI: 10.1371/journal.pone.0039561
  • Peer Reviewed
• [Journal Article] Effects of Image Distortion Correction on Voxel-based Morphometry (2012)
  • Author(s): M.Goto, O.Abe, et al
  • Journal Title: Magn Reson Med Sci Volume: 11 Pages: 27-34
  • NAID: 10030284763
  • Peer Reviewed
• [Journal Article] Cognitive status correlates with white matter alteration in Parkinson's disease (2011)
  • Author(s): Hattori T
  • Journal Title: Hum Brain Mapp Volume: 33 (3) Issue: 3 Pages: 727-739
  • DOI: 10.1002/hbm.21245
  • Peer Reviewed
• [Journal Article] et al. Gray and white matter asymmetries in healthy individuals aged 21-29 years: A voxel-based morphometry and diffusion tensor imaging study (2011)
  • Author(s): Takao H.,Abe O.
  • Journal Title: Hum Brain Mapp Volume: 32 Issue: 10 Pages: 1762-73
  • DOI: 10.1002/hbm.21145
  • Peer Reviewed
• [Journal Article] Accelerated hippocampal volume reduction in post-menopausal women : an additional study with Atlas-based method (2011)
  • Author(s): M.Goto, O.Abe, et al
  • Journal Title: Radiol Phys Technol Volume: 4 Issue: 2 Pages: 185-8
  • DOI: 10.1007/s12194-011-0120-7
  • Peer Reviewed
• [Journal Article] Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects (2011)
  • Author(s): M.Goto, O.Abe, et al
  • Journal Title: Neuroradiology Volume: 53 Issue: 8 Pages: 617-22
  • DOI: 10.1007/s00234-011-0863-1
  • Peer Reviewed
• [Journal Article] Effects of age and gender on white matter integrity (2011)
  • Author(s): S.Inano, H.Takao, N.Hayashi, O.Abe, et al
  • Journal Title: AJNR Am J Neuroradiol Volume: 32 Issue: 11 Pages: 2103-9
  • DOI: 10.3174/ajnr.a2785
  • Peer Reviewed
• [Journal Article] Gray and white matter asymmetries in healthy individuals aged 21-29 years : A voxel-based morphometry and diffusion tensor imaging study. (2011)
  • Author(s): Takao H., Abe O., et al
  • Journal Title: Hum Brain Mapp Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] et al Association between the oxytocin receptor gene and amygdalar volume in healthy adults . (2010)
  • Author(s): Inoue H.,Yamasue H.,Tochigi M.,Abe O.
  • Journal Title: Biol Psychiatry Volume: 68 Issue: 11 Pages: 1066-1072
  • DOI: 10.1016/j.biopsych.2010.07.019
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders (2010)
  • Author(s): Yamasaki, S., Yamasue, H., Abe, O., Suga, M., Yamada, H., Inoue, H., Kuwabara, H., Kawakubo, Y., Yahata, N., Aoki, S., Kano, Y., Kato, N. & Kasai, K
  • Journal Title: Biol Psychiatry Volume: 68 Issue: 12 Pages: 1141-1147
  • DOI: 10.1016/j.biopsych.2010.07.012
  • Peer Reviewed
• [Journal Article] Association between the oxytocin receptor gene and amygdalar volume in healthy adults. (2010)
  • Author(s): Inoue H., Yamasue H., Tochigi M., Abe O., et al
  • Journal Title: Biol Psychiatry Volume: 68 Pages: 1066-1072
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders. (2010)
  • Author(s): Yamasaki S., Yamasue H., Abe O., et al
  • Journal Title: Biol Psychiatry Volume: 68 Pages: 1141-1147
  • Peer Reviewed
• [Presentation] これでわかる画像統計解析 (2012)
  • Author(s): 阿部修
  • Organizer: 第15回Parallel Imaging Symposium.
  • Place of Presentation: 東京、有明
  • Year and Date: 2012-07-21
• [Presentation] 拡散テンソル解析の基礎と応用 (2012)
  • Author(s): 阿部修
  • Organizer: 精神疾患の脳画像研究チュートリアル
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-01-22
• [Presentation] et al Effects of distortion and inhomogeneity correction on brain morphometry with 3t mri using siena. (2012)
  • Author(s): Abe O
  • Organizer: 18th Annual Meeting of The Organization for Human Brain Mapping
  • Place of Presentation: Beijing, China
• [Presentation] Effects of distortion and inhomogeneity correction on brain morphometry with 3t mri using siena. (2012)
  • Author(s): Abe O, et al
  • Organizer: 18th Annual Meeting of The Organization for Human Brain Mapping
  • Place of Presentation: Beijing, China
• [Presentation] Are autistic brain structural abnormalities associated with perinatal and genetic factors? (2012)
  • Author(s): Yamasue H, Kuwabara H, Aoki Y, Saito Y, Yahata N, Natsubori T, Iwashiro N, Takano Y, Inoue H, Yasumasa N, Takao H, Abe O, et al
  • Organizer: Society of Biological Psychiatry 67th Annual Scientific Meeting.
  • Place of Presentation: Philadelphia, Pennsylvania
• [Presentation] An fmri study of response to peer rejection and acceptance in depressed adolescents. (2012)
  • Author(s): Yamasue H, Kuwabara H, Aoki Y, Saito Y, Yahata N, Natsubori T, Iwashiro N, Takano Y, Inoue H, Yasumasa N, Takao H, Abe O, et al
  • Organizer: Society of Biological Psychiatry 67th Annual Scientific Meeting.
  • Place of Presentation: Philadelphia, Pennsylvania
• [Presentation] Voxel-based analyses of the brain volume and diffusion tensor (2012)
  • Author(s): 阿部 修
  • Organizer: 産業医科大学放射線科学教室招待講演
  • Place of Presentation: 北九州市、福岡
  • Invited
• [Presentation] 教育講演 脳画像統計解析の基礎と研究応用 (2012)
  • Author(s): 阿部 修
  • Organizer: NPO 法人 日本歯科放射線学会 第215回関東地方会・第32回北日本地方会・第20回合同地方会
  • Place of Presentation: 日本大学松戸歯学部旧病院棟2階 MD ホール
  • Invited
• [Presentation] Voxel-based Analyses of the Brain volume and Diffusion Tensor. (2011)
  • Author(s): O. Abe
  • Organizer: The Centenary and Symposium of NTUH Radiology
  • Place of Presentation: NTUH International Convention Center, Taiwan
  • Year and Date: 2011-11-19
• [Presentation] Voxel-based Analyses of the Brain volume and Diffusion Tensor (2011)
  • Author(s): O.Abe
  • Organizer: The Centenary and Symposium of NTUH Radiology
  • Place of Presentation: NTUH International Convention Center, Taiwan(招待講演)
  • Year and Date: 2011-11-19
• [Presentation] 脳画像統計解析 (2011)
  • Author(s): 阿部修特別講演
  • Organizer: 第13回東京臨床脳画像解析研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-26
• [Presentation] 特別講演脳画像統計解析 (2011)
  • Author(s): 阿部修
  • Organizer: 第13回東京臨床脳画像解析研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-05-26
• [Presentation] et al Voxel-based volumetric results without ?with image correction using the two segmentation algorithms. (2011)
  • Author(s): T. Shizukuishi, O. Abe
  • Organizer: 17th Annual Meeting of The Organization for Human Brain Mapping.
  • Place of Presentation: Quebec, Canada
• [Presentation] シンポジウム:精神疾患における脳MRI解析研究精神疾患におけるDTI解析成果 (2011)
  • Author(s): 阿部修,他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
• [Presentation] Voxel-based volumetric results without/with image correction using the two segmentation algorithms (2011)
  • Author(s): T.Shizukuishi, O.Abe, et al
  • Organizer: 17th Annual Meeting of The Organization for Human Brain Mapping
  • Place of Presentation: Quebec, Canada
• [Presentation] シンポジウム:精神疾患における脳MRI解析研究精神疾患におけるDTI解析成果 (2011)
  • Author(s): 阿部修, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉(招待講演)
• [Presentation] シンポジウム:精神疾患における脳MRI解析研究DTI解析入門 (2011)
  • Author(s): 青木茂樹, 堀正明, 増谷佳孝, 阿部修
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉(招待講演)
• [Presentation] ランチョンセミナー:normal aging in the central nervous system from technical aspects (2011)
  • Author(s): 阿部修
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉(招待講演)
• [Presentation] Body mass index (BMI)に関連する大脳白質部位:TBSSを用いた拡散テンソル解析 (2011)
  • Author(s): 下地啓五, 青木茂樹, 阿部修, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
• [Presentation] 3T-MRI T1WIを用いた健常人におけるWMS-Rと灰白質容積の相関 (2011)
  • Author(s): 後藤政実, 阿部修, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
• [Presentation] 統合失調症におけるmismatch negativity(MMN)と拡散テンソルに関する解析 (2011)
  • Author(s): 早川弥生, 下地啓五, 鎌形康司, 堀正明, 伊藤賢司, 阿部修, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
• [Presentation] 脳画像解析のためのMRI画像における幾何学的歪みの補正法の提案とその評価-J-ADNI研究 (2011)
  • Author(s): 舞草伯秀, 山下典生, 田中健一郎, 阿部修, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
• [Presentation] パーキンソン病における白質障害と認知機能との関連～3TMRIによる検討 (2011)
  • Author(s): 鎌形康司, 阿部修, 他
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
• [Presentation] 脳画像統計解析 (2010)
  • Author(s): 阿部修
  • Organizer: 第46回日本医学放射線学会秋季臨床大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-20