Early prediction of therapeutic effect of molecular targeting therapy for solid malignant tumor with imaging biomarkers

• Project/Area Number: 22591319
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KOBAYASHI Satoshi 金沢大学, 保健学系, 准教授 (30313638)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 肝細胞癌 / 分子標的治療 / 造影CT / Dual-Energy CT / ヨードマップ

Research Abstract

Dilatation of intratumoral vessels on multiphasic contrast enhanced CT was estimated to be one of the key findings for prediction of early therapeutic effect evaluation of molecular-targeting therapy for hepatocellular carcinoma (HCC). There are no significant correlation between hemodynamic parameters of CT perfusion just after starting of molecular-targeting therapy for HCC and long term therapeutic effect of it. In contrast, intratumoral iodine measurement obtained by dual-energy CT technique might be used as surrogate marker for early prediction of therapeutic effect of molecular targeting therapy for HCC.

Research Products

• [Journal Article] Intrahepatic periportalenhancement on hepatobiliary phase images of Gd-EOB-DTPA enhanced MRI: Imaging findings and the prevalence in various hepatobiliary diseases (2013)
  • Author(s): Kobayashi S, Matsui O, Gabata T, Koda W, Minami T, Kozaka K, Kitao A, Yoneda N, Yoshida K
  • Journal Title: Jpn J Radiol Volume: 31 Issue: 1 Pages: 9-15
  • DOI: 10.1007/s11604-012-0136-x
  • Peer Reviewed
• [Journal Article] Intranodular signal intensity analysis of hypovascular high-risk borderline lesions of HCC that illustrate multi-step hepatocarcinogenesis within the nodule on Gd-EOB-DTPA-enhanced MRI (2012)
  • Author(s): Kobayashi S, Matsui O, Gabata T, Koda W, Minami T, Ryu Y, Kozaka K, Kitao A
  • Journal Title: Eur J Radiol Volume: 81 Pages: 3839-3845
  • Peer Reviewed
• [Journal Article] Relationship between signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging and prognosis of borderline lesions of hepatocellular carcinoma (2012)
  • Author(s): Kobayashi S, Matsui O, Gabata T, Koda W, Minami T, Ryu Y, Kozaka K, Kitao A
  • Journal Title: Eur J Radiol Volume: 81 Issue: 11 Pages: 3002-3009
  • DOI: 10.1016/j.ejrad.2012.03.029
  • Peer Reviewed
• [Journal Article] Intranodular signal intensity analysis of hypovascular high-risk borderline lesions of HCC that illustrate multi-step hepatocarcinogenesis within the nodule on Gd-EOB-DTPA-enhanced MRI. (2012)
  • Author(s): Kobayashi S, et al
  • Journal Title: Eur J Radiol. Volume: 81 Issue: 12 Pages: 3839-3845
  • DOI: 10.1016/j.ejrad.2012.06.027
  • Peer Reviewed
• [Journal Article] Gadolinium ethoxybenzyl diethylenetriamine pentaacetic Acid-enhanced magnetic resonance imaging findings of borderline lesions at high risk for progression to hypervascular classic hepatocellular carcinoma (2011)
  • Author(s): Kobayashi S, Matsui O, Gabata T, Koda W, Minami T, Ryu Y, Kawai K, Kozaka K
  • Journal Title: J Comput Assist Tomogr Volume: 35 Issue: 2 Pages: 181-186
  • DOI: 10.1097/rct.0b013e3182026f3b
  • NAID: 120003141557
  • Peer Reviewed
• [Journal Article] 画像を用いた肝細胞性結節の悪性度推定および早期肝細胞がんの画像診断の進歩 (2011)
  • Author(s): 小林 聡, 松井 修, 蒲田敏文, 香田渉, 南 哲弥, 龍 泰治, 小坂一斗, 北尾 梓
  • Journal Title: 最新医学 Volume: 66 Pages: 1760-1764
  • URL: http://ci.nii.ac.jp/naid/40018951688
  • Peer Reviewed
• [Journal Article] 薬物トランスポーターからみたGd-EOB-DTPA 造影MRI (2011)
  • Author(s): 小林 聡, 北尾 梓, 松井 修, 蒲田敏文, 眞田順一郎, 香田 渉, 南 哲弥, 龍 泰治, 川井恵一, 新村理絵子, 小坂一斗, 中村功一, 米田憲秀
  • Journal Title: 臨床画像 Volume: 27 Pages: 302-309
  • URL: http://www.medicalview.co.jp/catalog/MAGA09471-11-03-0.html
• [Journal Article] 薬物トランスポーターからみたGd-EOB-DTPA造影MRI (2011)
  • Author(s): 小林聡, ほか
  • Journal Title: 臨床画像 Volume: 27 Pages: 302-309
• [Journal Article] Radiologic manifestation of hepatic pseudolesion and pseudotumor in the third inflow area (2010)
  • Author(s): Kobayashi S, Gabata T, Matsui O
  • Journal Title: Imaging in Medicine Volume: 2 Issue: 5 Pages: 519-528
  • DOI: 10.2217/iim.10.50
  • NAID: 120002511712
  • Peer Reviewed
• [Journal Article] d-EOB-DTPA造影MRIによる肝腫瘍画像診断 (2010)
  • Author(s): 小林 聡, 松井 修, 蒲田敏文, 眞田順一郎, 香田 渉, 南 哲弥, 龍 泰治, 川井恵一,新村理絵子, 小坂一斗, 米田憲秀, 杉盛夏樹, 五十嵐紗耶, 松原崇史
  • Journal Title: Rad Fa Volume: 8 Pages: 78-80
  • URL: http://www.e-radfan.com/category/shop-radfan/
• [Journal Article] Gd-EOB-DTPA造影MRIによる肝腫瘍画像診断 (2010)
  • Author(s): 小林聡, ほか
  • Journal Title: Rad Fan Volume: 8 Pages: 78-80
• [Journal Article] Radiologic manifestation of hepatic pseudolesion and pseudotumor in the third inflow area. (2010)
  • Author(s): Kobayashi S, et al.
  • Journal Title: Imaging Med. Volume: 2 Pages: 519-528
  • NAID: 120002511712
  • Peer Reviewed
• [Presentation] Image Based Analysis of Reduction Effect On Multicentric Type Recurrence of Hepatocellular Carcinoma With Peretinoin (2012)
  • Author(s): Kobayashi S, Gabata T, Matsui O
  • Organizer: International Liver Cancer Association (ILCA) 2012
  • Place of Presentation: Intercontinental Hotel Berlin (Germany)
  • Year and Date: 2012-09-15
• [Presentation] Image Based Analysis of Reduction Effect On Multicentric Type Recurrence of Hepatocellular Carcinoma With Peretinoin” (2012)
  • Author(s): Kobayashi S, et al
  • Organizer: International Liver Cancer Association
  • Place of Presentation: InterContinental Hotel Berlin （ドイツ）
• [Presentation] Radiologic manifestation of hepatic pseudolesions and pseudotumors in the third inflow area (2011)
  • Author(s): Kobayashi S, Matsui O
  • Organizer: 9th Barcan Congress of Radiology
  • Place of Presentation: Cluj Napoca conference center (Romania)
  • Year and Date: 2011-10-07
• [Presentation] Radiologic manifestation of hepatic pseudolesions and pseudotumors in the third inflow area (2011)
  • Author(s): Kobayashi S, et al
  • Organizer: 第9回バルカン放射線学会
  • Place of Presentation: Cluj Napoca (Romania)
  • Year and Date: 2011-10-07
• [Presentation] 肝細胞癌に対するソラフェニブ治療前後におけるperfusion CTパラメータの変化に関する初期検討 (2011)
  • Author(s): 小林 聡
  • Organizer: 第47回日本肝癌研究会
  • Place of Presentation: 静岡県コンベンションセンター(静岡県)
  • Year and Date: 2011-07-28
• [Presentation] Quantitative analysis of Iodine concentration in hepatic tumors using dual-energy multiphasic CT as objective index for assessment of tumor vascularity: initial experience (2011)
  • Author(s): Kobayashi S, Matsui O, Otani K, Gabata T, Koda W, Minami T, Ryu Y, Kawai K, Kozaka K
  • Organizer: European congress of radiology (ECR)
  • Place of Presentation: Austria Center (Austria)
  • Year and Date: 2011-03-04
• [Presentation] Quantitative analysis of Iodine concentration in hepatic tumors using dual-energy multiphasic CT as objective index for assessment of tumor vascularity : initial experience. (2011)
  • Author(s): Kobayashi S, et al.
  • Organizer: European Congress of Radiology
  • Place of Presentation: Austria Center (Austria)
  • Year and Date: 2011-03-04
• [Presentation] Initial experience of Dual source Dual energy CT for hepatic imaging: Impact of Iodine Map on hemodynamic analysis of the liver lesion (2011)
  • Author(s): Kobayashi S, Matsui O, Gabata T, Koda W, Minami T, Ryu Y, Kawai K, Kozaka K
  • Organizer: European congress of radiology (ECR)
  • Place of Presentation: Austria Center (Austria)
  • Year and Date: 2011-03-03
• [Presentation] Initial experience of Dual source Dual energy CT for hepatic imaging : Impactof Iodine Map on hemodynamic analysis of the liver lesion. (2011)
  • Author(s): Kobayashi S, et al.
  • Organizer: European Congress of Radiology
  • Place of Presentation: Austria Center(Austria)
  • Year and Date: 2011-03-03
• [Presentation] d-EOB-DTPA造影MRIによる肝細胞性結節性病変の診断 (2011)
  • Author(s): 小林 聡
  • Organizer: 先端医用画像技術講演会 in 金沢
  • Place of Presentation: 地場産業センター (石川県)
  • Year and Date: 2011-02-19
• [Presentation] Gd-EOB-DTPA造影MRIによる肝細胞性結節性病変の診断 (2011)
  • Author(s): 小林聡
  • Organizer: 先端医用画像技術講演会in金沢2011
  • Place of Presentation: 地場産業センター(石川県)(招待講演)
  • Year and Date: 2011-02-19
• [Presentation] 分子標的治療による画像の変化と治療効果判定 ソラフェニブ投与後の肝細胞癌の造影CT所見と治療効果に関する初期検討 (2011)
  • Author(s): 小林 聡
  • Organizer: 第3回肝がん分子標的治療研究会
  • Place of Presentation: 海峡メッセ (山口県)
  • Year and Date: 2011-01-15
• [Presentation] 分子標的治療による画像の変化と治療効果判定ソラフェニブ投与後の肝細胞癌の造影CT所見と治療効果に関する初期検討 (2011)
  • Author(s): 小林聡, ほか
  • Organizer: 第3回肝がん分子標的治療研究会
  • Place of Presentation: 海峡メッセ (山口県)
  • Year and Date: 2011-01-15
• [Presentation] 動注CTで診断した高危険度肝細胞癌境界病変のEOB造影MRI肝細胞相所見と結節の転帰について (2010)
  • Author(s): 小林 聡
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: 筑波国際会議場 (茨城県)
  • Year and Date: 2010-09-30