| Project/Area Number |
22591326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKUMA Hajime 三重大学, 大学院・医学系研究科, 教授 (60205797)
TAKEDA Kan 三重大学, 医学部附属病院, 病院長 (70106988)
NAKAYAMA Ryouhei 三重大学, 医学部附属病院, 助教 (20402688)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | エックス線 / CT / 冠動脈 / 心筋血流 / プラーク / 血流予備能 |
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| Research Abstract |
We have developed a 320-slice MDCT protocol consisting of resting-state coronary CT angiography and pharmacologic-stress myocardial perfusion CT. However, its diagnostic performance was not high enough to be clinically considered when fractional flow reserve and MRI were used as gold standard. We, then, changed the CT platform to dual source CT with much higher temporal resolution, and developed a protocol consisting of coronary CT angiography, stress dynamic myocardial perfusion and CT delayed enhancement. This new protocol showed high diagnostic accuracy of 92% when compared with invasive coronary angiography and stress myocardial perfusion MRI.
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