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Diagnostic imaging of breast cancer using newly-developed dedicated PET scanners.

Research Project

Project/Area Number 22591329
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

NAKAMOTO Yuji  京都大学, 医学研究科, 講師 (20360844)

Co-Investigator(Kenkyū-buntansha) ISHIDU Koichi  京都大学, 大学院・医学研究科, 准教授 (50314224)
KAWASHIMA Hidekazu  国立循環器病研究センター, 画像診断医学部, 室長 (70359438)
MITSUMORI Michihide  京都大学, 大学院・医学研究科, 准教授 (10263089)
UENO Takayuki  京都大学, 大学院・医学研究科, 助教 (40452362)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsフルオロデオキシグルコース / 画像診断 / 乳癌 / 早期発見 / 高感度 / 高分解能 / FDG / PET
Research Abstract

Two newly-developed dedicated PET scanners (dbPET-C and dbPET-O) are clinically feasible, with sensitivities of 81%(92%) and 84%(95%), respectively, in patient-basis, and 78%(89%) and 81%(92%), respectively, in lesion-basis.(Results after excluding lesions out of scanning range are shown in parentheses) Although superiority of diagnostic performance of these scanners were not demonstrated partly because patients had relatively larger tumors, more precise histopathologic information was provided when lesions were depicted. Further investigations are required to evaluate the quantitative parameters and prognostic values acquired by this modality.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Presentation (17 results) (of which Invited: 1 results) Book (5 results)

  • [Journal Article] Clinical value of (11)C-methionine PET/CT in patients with plasma cell malignancy: comparison with (18)F-FDG PET/CT2013

    • Author(s)
      Nakamoto Y, et al
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: Vol.40、No.5 Issue: 5 Pages: 708-715

    • DOI

      10.1007/s00259-012-2333-3

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual-time-point 18F-FDG PET/CT in patients with colorectal cancer: clinical value of early delayed scanning2012

    • Author(s)
      Miyake KK, Nakamoto Y, Togashi K
    • Journal Title

      Ann Nucl Med

      Volume: Vol.18、No.6 Issue: 6 Pages: 492-500

    • DOI

      10.1007/s12149-012-0599-y

    • NAID

      10030949504

    • Year and Date
      2012-04-11
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical performance of 2 dedicated PET scanners for breast imaging: initial evaluation2012

    • Author(s)
      Iima M, Nakamoto Y, et al
    • Journal Title

      J Nucl Med

      Volume: Vol.53、No.10 Issue: 10 Pages: 1534-1542

    • DOI

      10.2967/jnumed.111.100958

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Utility of FDG PET/CT in IgG4-related systemic disease2012

    • Author(s)
      Nakatani K, Nakamoto Y, Togashi K
    • Journal Title

      Clin Radiol

      Volume: Vol.67、No.4 Issue: 4 Pages: 297-305

    • DOI

      10.1016/j.crad.2011.10.011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between 18F-Fluorodeoxyglucose accumulation and KRAS/BRAF mutations in colorectal cancer2012

    • Author(s)
      Kawada K, Nakamoto Y, Kawada M, et al
    • Journal Title

      Clinical Cancer Research

      Volume: 18 Issue: 6 Pages: 1696-703

    • DOI

      10.1158/1078-0432.ccr-11-1909

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles and limitations of FDG PET in pediatric non-Hodgkin lymphoma2012

    • Author(s)
      Nakatani K, Nakamoto Y, et al
    • Journal Title

      Clin Nucl Med

      Volume: Vol.37、No.7 Issue: 7 Pages: 656-662

    • DOI

      10.1097/rlu.0b013e318238f72b

    • NAID

      120005307068

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 乳房専用近接型PET装置を用いた乳癌の画像診断2012

    • Author(s)
      中本裕士
    • Journal Title

      日本臨牀 2012年増刊号 乳癌(第2版)

      Volume: 1028 Pages: 349-353

    • Related Report
      2012 Annual Research Report
  • [Journal Article] contrast material needed after treatment of malignant lymphoma in positron emission tomography/computed tomography?2011

    • Author(s)
      Nakamoto Y, et al
    • Journal Title

      Ann Nucl Med

      Volume: Vol.25、No.2 Issue: 2 Pages: 93-99

    • DOI

      10.1007/s12149-010-0429-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical value of FDG-PET for preoperative evaluation of endometrial cancer2011

    • Author(s)
      Suga T, Nakamoto Y, Saga T, Higashi T, Hamanaka Y, Tatsumi M, Hayashida K, Hara T, Konishi I, Fujii S, Togashi K.
    • Journal Title

      Ann Nucl Med

      Volume: 25(4) Issue: 4 Pages: 269-75

    • DOI

      10.1007/s12149-011-0474-2

    • NAID

      10028999621

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhomogeneous bone marrow uptake caused by G-CSF mimics multiple bone metastases on FDG-PET2010

    • Author(s)
      Nakamoto Y, et al
    • Journal Title

      Clin Nucl Med

      Volume: Vol.35、No.2 Issue: 2 Pages: 74-76

    • DOI

      10.1097/rlu.0b013e3181c7bf4e

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of positive FDG-PET findings in patients with high CEA levels2010

    • Author(s)
      Suga T, Nakamoto Y, et al
    • Journal Title

      Ann Nucl Med

      Volume: Vol.24、No.6 Issue: 6 Pages: 433-439

    • DOI

      10.1007/s12149-010-0387-5

    • NAID

      10026596303

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of FDG-PET images after stereotactic body radiation therapy for lung cancer2010

    • Author(s)
      Matsuo Y, Nakamoto Y, Nagata Y, Shibuya K, Takayama K, Norihisa Y, Narabayashi M, Mizowaki T, Saga T, Higashi T, Togashi K, Hiraoka M.
    • Journal Title

      Radiother Oncol.

      Volume: 97(2) Issue: 2 Pages: 200-4

    • DOI

      10.1016/j.radonc.2010.04.011

    • NAID

      120002674607

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 高分解能・高感度型乳腺用 PET 装置の初期使用経験2013

    • Author(s)
      中本裕士, 石津浩一、三宅可奈江、富樫かおり
    • Organizer
      高分解能・高感度型乳腺用 PET 装置の初期使用経験.
    • Place of Presentation
      大宮ソニックシティ さいたま埼玉県
    • Year and Date
      2013-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] マンモPET 検査の安楽度および撮像範囲の検討:乳腺 MRI との比較2013

    • Author(s)
      井上美香、中本裕士, 川瀬滋人
    • Organizer
      マンモPET 検査の安楽度および撮像範囲の検討:乳腺 MRI との比較.
    • Place of Presentation
      大宮ソニックシティ さいたま 埼玉県
    • Year and Date
      2013-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 新型乳房専用 PET 装置の診断精度2012

    • Author(s)
      中本裕士ら
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      さっぽろ芸術文化の館/ロイトン札幌 札幌 北海道
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] ランチョンセミナー: 乳房専用PET 装置による乳癌の画像診断2012

    • Author(s)
      中本裕士
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      さっぽろ芸術文化の館/ロイトン札幌 札幌 北海道
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Diagnostic accuracy of two dedicated PET scanners for breast imaging2012

    • Author(s)
      Yuji Nakamoto, et al
    • Organizer
      SNM 2012 Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center, Miami Beach, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Distribution pattern assessment by dedicated breast PET and whole body PET/CT scanners in breast cancer2012

    • Author(s)
      Miami Beach Convention Center, Miami Beach, USA
    • Organizer
      SNM 2012 Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center, Miami Beach, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Diagnostic accuracy of two dedicated PET scanners for breast imaging.2012

    • Author(s)
      Yuji Nakamoto
    • Organizer
      SNM 2012 Annual Meeting
    • Place of Presentation
      Miami Beach, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] Distribution pattern assessment by dedicated breast PET and whole body PET/CT scanners in breast cancer.2012

    • Author(s)
      Shotaro Kanao
    • Organizer
      SNM 2012 Annual Meeting
    • Place of Presentation
      Miami Beach, FL
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳房専用PET装置による乳癌の画像診断2012

    • Author(s)
      中本裕士
    • Organizer
      第52回日本核医学会学術総会 ランチョンセミナー
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Performance characteristics of a new development dedicated breast PET scanner evaluated with the NEMA NU 2-2008 standard2011

    • Author(s)
      Mika Inoue, Yuji Nakamoto, et al
    • Organizer
      SNM 2011 Annual Meeting
    • Place of Presentation
      San Antonio Convention Center, San Antonio, USA
    • Year and Date
      2011-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Performance characteristics of a new development dedicated breast PET scanner evaluated with the NEMA NU 2-2008 standard2011

    • Author(s)
      Mika Inoue
    • Organizer
      SNM 2011 Annual Meeting
    • Place of Presentation
      San Antonio Convention Center, San Antonio, TX
    • Year and Date
      2011-06-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Diagnostic performance of newly-developed PET scanners for breast imaging2011

    • Author(s)
      Yuji Nakamoto, et al
    • Organizer
      SNM 2011Annual Meeting
    • Place of Presentation
      San Antonio Convention Center, San Antonio, USA
    • Year and Date
      2011-06-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Diagnostic performance of newly-developed PET scanners for breast imaging2011

    • Author(s)
      Yuji Nakamoto
    • Organizer
      SNM 2011 Annual Meeting
    • Place of Presentation
      San Antonio Convention Center, San Antonio, TX
    • Year and Date
      2011-06-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Current topics of positron emission tomography in breast cancer2011

    • Author(s)
      Yuji Nakamoto
    • Organizer
      Current topics of positron emission tomography in breast cancer
    • Place of Presentation
      Current topics of positron emission tomography in breast cancer
    • Year and Date
      2011-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Current topics of positron emission tomography in breast cancer2011

    • Author(s)
      Yuji Nakamoto
    • Organizer
      Kyoto Breast Cancer Consensus Conference 2011 International Convention
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Year and Date
      2011-04-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高分解能・高感度型乳腺用PET装置の初期使用経験2010

    • Author(s)
      中本裕士
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      さいたま市・大宮ソニックシティ
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] マンモPET検査の安楽度および撮像範囲の検討:乳腺MRIとの比較2010

    • Author(s)
      井上美香
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      さいたま市・大宮ソニックシティ
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Book] 悪性リンパ腫の FDG-PET/CT. 放射線医学 核医学・PET・SPECT2012

    • Author(s)
      中本裕士
    • Publisher
      小須田茂
    • Related Report
      2012 Final Research Report
  • [Book] NET の局在診断、ソマトスタチン受容体シンチグラフィ(SRS)2012

    • Author(s)
      中本裕士
    • Publisher
      コンセンサス癌治療
    • Related Report
      2012 Final Research Report
  • [Book] PET(/CT), SPECT(/CT)検査の動向と臨床現場からのメッセージ2012

    • Author(s)
      中本裕士
    • Publisher
      インナービジョン
    • Related Report
      2012 Final Research Report
  • [Book] 乳房専用近接型 PET 装置を用いた乳癌の画像診断2012

    • Author(s)
      中本裕士
    • Publisher
      日本臨牀
    • Related Report
      2012 Final Research Report
  • [Book] 画像診断. みんなに役立つ 悪性リンパ腫の基礎と臨床 改訂版

    • Author(s)
      中本裕士
    • Publisher
      押味和夫
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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