Intratumoral heterogeneity of radiotracer uptake on new-generation PET systems: association with biologic behavior and treatment response

• Project/Area Number: 22591331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: TATSUMI Mitsuaki 大阪大学, 医学部附属病院, 講師 (60397700)
• Co-Investigator(Kenkyū-buntansha): KANAI Yasukazu 大阪大学, 医学系研究科, 助教 (60397643)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: PET / 腫瘍 / 不均一

Research Abstract

Intratumoral heterogeneity of radiotracer uptake is often observed on new-generation PET systems. We developed the method of quantitative analysis for intratumoral heterogeneity in human PET images. Comparison of lymphoma and gastrointestinal stromal tumor or of uterine cervical and endometrial cancer revealed the latter of each analysis showed greater heterogeneity. Intratumoral heterogeneity was demonstrated to change after treatment in the evaluation of esophageal cancer and lung cancer before and after chemotherapy. Greater intratumoral heterogeneity in the pretreatment status associated with poor treatment response.

Research Products

• [Journal Article] Intratumoral heterogeneity of F-18 FDG uptake differentiates between gastrointestinal stromal tumors and abdominal malignant lymphomas on PET/CT (2012)
  • Author(s): Watabe T, Tatsumi M
  • Journal Title: Annals of Nuclear Medicine Volume: 3 Issue: 3 Pages: 222-227
  • DOI: 10.1007/s12149-011-0562-3
  • NAID: 10030623799
  • Peer Reviewed
• [Presentation] 分子標的治療が行われた肺癌における腫瘍内 FDG の不均一性および metabolictumor volume の変化 (2012)
  • Author(s): 巽 光朗、渡部 直史、
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-10-12
• [Presentation] Changes of intratumoral heterogeneity of F-18 FDG uptake and metabolic tumor volume in lung cancer receiving gefitinib therapy (2012)
  • Author(s): Tatsumi M, Watabe T
  • Organizer: Society of Nuclear Medicine's 59th Annual Meeting
  • Place of Presentation: Miami Beach, U.S.A
  • Year and Date: 2012-06-11
• [Presentation] Changes of intratumoral heterogeneity of FDG uptake in esophageal cancer before and after chemotherapy (2012)
  • Author(s): Watanabe S, Tatsumi M
  • Organizer: Society of Nuclear Medicine's 59th Annual Meeting
  • Place of Presentation: Miami Beach, U.S.A
  • Year and Date: 2012-06-11
• [Presentation] Changes of intratumoral heterogeneity of F-18 FDG uptake and metabolic tumor volume in lung cancer receiving gefitinib therapy (2012)
  • Author(s): Tatsumi M, Watabe T, et al.
  • Organizer: Society of Nuclear Medicine's 59th Annual Meeting
  • Place of Presentation: Miami Beach, USA
• [Presentation] Changes of intratumoral heterogeneity of FDG uptake in esophageal cancer before and after chemotherapy (2012)
  • Author(s): Watanabe S, Tatsumi M, et al.
  • Organizer: Society of Nuclear Medicine's 59th Annual Meeting
  • Place of Presentation: Miami Beach, USA
• [Presentation] 分子標的治療が行われた肺癌における腫瘍内FDGの不均一性およびmetabolic tumor volumeの変化 (2012)
  • Author(s): 巽 光朗、渡部直史、他
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Intratumoral heterogeneity in abdominal GIST and lymphoma: A key finding on F-18 FDG PET/CT (2011)
  • Author(s): Watabe T, Tatsumi M
  • Organizer: Society of Nuclear Medicine's 57th Annual Meeting
  • Place of Presentation: Salt Lake City, U.S.A.
  • Year and Date: 2011-06-07
• [Presentation] 子宮頸癌及び体癌 PET/CT における FDG 集積の腫瘍内均一性と辺縁不整度の評価 (2011)
  • Author(s): 巽 光朗、礒橋 佳也子
  • Organizer: 第70回日本医学放射線学会総会
  • Place of Presentation: Web開催(震災のため)
  • Year and Date: 2011-05-20
• [Presentation] 子宮頸癌及び体癌PET/CTにおけるFDG集積の腫瘍内均一性と辺縁不整度の評価 (2011)
  • Author(s): 巽光朗, 他
  • Organizer: 第70回日本医学放射線学会総会
  • Place of Presentation: (Web開催)(震災のため)
• [Presentation] Intratumoral heterogeneity in abdominal GIST and lymphoma : A key finding on F-18 FDG PET/CT. (2010)
  • Author(s): Watabe T, Tatsumi M, et al.
  • Organizer: Society of Nuclear Medicine's 57th Annual Meeting
  • Place of Presentation: Salt Lake City, U.S.A.
  • Year and Date: 2010-06-07