Intratumoral heterogeneity of radiotracer uptake on new-generation PET systems: association with biologic behavior and treatment response
| Project/Area Number |
22591331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Yasukazu 大阪大学, 医学系研究科, 助教 (60397643)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | PET / 腫瘍 / 不均一 |
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| Research Abstract |
Intratumoral heterogeneity of radiotracer uptake is often observed on new-generation PET systems. We developed the method of quantitative analysis for intratumoral heterogeneity in human PET images. Comparison of lymphoma and gastrointestinal stromal tumor or of uterine cervical and endometrial cancer revealed the latter of each analysis showed greater heterogeneity. Intratumoral heterogeneity was demonstrated to change after treatment in the evaluation of esophageal cancer and lung cancer before and after chemotherapy. Greater intratumoral heterogeneity in the pretreatment status associated with poor treatment response.
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Report
(4 results)
Research Products
(11 results)
