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Intratumoral heterogeneity in brain tumor using PET molecular imaging

Research Project

Project/Area Number 22591337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKagawa University

Principal Investigator

NISHIYAMA Yoshihiro  香川大学, 医学部, 教授 (50263900)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Yuka  香川大学, 医学部附属病院, 講師 (30335872)
KAWAI Nobuyuki  香川大学, 医学部, 准教授 (40294756)
KUDOMI Nobuyuki  香川大学, 医学部, 准教授 (20552045)
Co-Investigator(Renkei-kenkyūsha) AGA Fumitoshi  香川大学, 医学部附属病院, 病院助教 (30596078)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsPET 検査 / F-18 FDG / C-11 methionine / 分子イメージング / 不均一性 / 脳腫瘍 / PET検査 / F-18 FLT
Research Abstract

Heterogeneity is a recognized characteristic of malignant tumor. It has been reported to be associated with factors that influence resistance to therapy such as histological features including cellular proliferation, necrosis, and physiological features including degree of vascularity, gene expression, energy metabolism, and oxygenation. All these aspects of intratumoral heterogeneity may affect the biological behavior of tumors in patients, which may manifest as variability in prognosis and treatment response. The purpose of this study was to quantitatively measure intratumoral heterogeneity, and to delineate the differences in the distribution of F-18 FDG, F-18 FLT, and C-11 methionine in patients with primary brain tumors.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Correlation of 18F-FLT uptake with tumor grade and Ki-67 immunohistochemistry in patients with newly diagnosed and recurrent gliomas2012

    • Author(s)
      Yamamoto Yuka 、 Aga Fumitoshi 、 Kawai Nobuyuki、Kudomi Nobuyuki、Nishiyama Yoshihiro、他
    • Journal Title

      Journal of Nuclear Medicine

      Volume: Vol 53 Pages: 1911-1915

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia assessed by 18F-fluoromisonidazole positron emission tomography in newly diagnosed gliomas2012

    • Author(s)
      Yamamoto Yuka 、 Kawai Nobuyuki 、 Aga Fumitoshi、Kudomi Nobuyuki、Nishiyama Yoshihiro 、 他
    • Journal Title

      Nuclear Medicine Communications

      Volume: Vol 33 Pages: 621-625

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of 18F-FLT uptake with tumor grade and Ki-67 immunohistochemistry in patients with newly diagnosed and recurrent gliomas2012

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      The Journal of Nuclear Medicine

      Volume: 53 Issue: 12 Pages: 1911-1915

    • DOI

      10.2967/jnumed.112.104729

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of biological aggressiveness assessed by ^<11>C-methionine PET and hypoxic burden assessed by ^<18>F-fluoromisonidazole PET in newly diagnosed glioblastoma2011

    • Author(s)
      Kawai Nobuyuki
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 38 Pages: 441-450

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pixel-based analysis of 18F-FDG, 18F-FLT, and 11C-methionine PET in high-grade brain gliomas2012

    • Author(s)
      Aga Fumitoshi 、 Yamamoto Yuka 、 Kawai Nobuyuki、Kudomi Nobuyuki、Nishiyama Yoshihiro、他
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Miami Beach、Florida、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Intratumoral FDG metabolic heterogeneity in newly diagnosed malignant primary brain tumor: comparison with glioblastoma and lymphoma s2011

    • Author(s)
      Aga Fumitoshi 、 Yamamoto Yuka 、 Kawai Nobuyuki、Kudomi Nobuyuki、Nishiyama Yoshihiro 、 他
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      San Antonio、Texas、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Intratumoral FDG metabolic heterogeneity in newly diagnosed malignant primary brain tumor : comparison with glioblastoma and lymphoma2011

    • Author(s)
      Aga Fumitoshi
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      San Antonio, Texas (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Assessment of hypoxia using F-18 fluoromisonidazole PET in brain gliomas and correlation of F-18 FDG PET and Gd-DTPA enhanced MRI2010

    • Author(s)
      Yamamoto Yuka
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, Utah(USA)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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