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The assessment of hypoxia with PET molecular imaging in lung cancer

Research Project

Project/Area Number 22591338
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKagawa University

Principal Investigator

YAMAMOTO Yuka  香川大学, 医学部附属病院, 講師 (30335872)

Co-Investigator(Kenkyū-buntansha) NISHIYAMA Yoshihiro  香川大学, 医学部, 教授 (50263900)
HABA Reiji  香川大学, 医学部附属病院, 准教授 (90304584)
KUDOMI Nobuyuki  香川大学, 医学部, 准教授 (20552045)
Co-Investigator(Renkei-kenkyūsha) AGA Fumitoshi  香川大学, 医学部附属病院, 病院助教 (30596078)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺癌 / 分子イメージング / PET 検査 / 低酸素細胞 / F-18 FMISO / F-18 FDG / PET検査
Research Abstract

Tumor hypoxia induces aggressiveness, increases metastatic potential, and promotes tumor progression and resistance to anticancer therapy. In-vivo measurement of hypoxia in individual patients is of clinical interest. Imaging with radiolabeled imidazole derivatives offers a noninvasive assessment of tumor hypoxia. Nitroimidazoles are metabolized by intracellular nitroreductases and at low oxygen levels serve as competing electron acceptors. The metabolism of nitroimidazoles relies on active electron transport enzymes and thus does not occur in nectrotic tissue. One of the most widely used PET radiotracers for hypoxia is F-18 fluoromisonidazole (F-18 FMISO), a nitroimidazole derivative. The purpose of this study was to evaluate the degree of hypoxia in lung cancer using F-18 FMISO PET and to compare the results with F-18 FDG PET.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Correlation of 18F-FLT uptake with tumor grade and Ki-67 immunohistochemistry in patients with newly diagnosed and recurrent gliomas2012

    • Author(s)
      Yamamoto Yuka 、 Aga Fumitoshi 、 Kawai Nobuyuki、Kudomi Nobuyuki、Nishiyama Yoshihiro、他
    • Journal Title

      Journal of Nuclear Medicine

      Volume: Vol 53 Pages: 1911-1915

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia assessed by 18F-fluoromisonidazole positron emission tomography in newly diagnosed gliomas2012

    • Author(s)
      Yamamoto Yuka 、 Kawai Nobuyuki 、 Aga Fumitoshi、Kudomi Nobuyuki、Nishiyama Yoshihiro 、 他
    • Journal Title

      Nuclear Medicine Communications

      Volume: Vol 33 Pages: 621-625

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia assessed by 18F-Fluoromisonidazole PET in newly diagnosed gliomas2012

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      Nuclear Medicine Communications

      Volume: 33 Issue: 6 Pages: 621-625

    • DOI

      10.1097/mnm.0b013e3283529984

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia assessed by ^<18>F-Fluoromisonidazole PET in newly diagaosed gliomas2012

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      Nucl Med Commun

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma2011

    • Author(s)
      Kawai Nobuyuki 、 Kudomi Nobuyuki 、Yamamoto Yuka、Nishiyama Yoshihiro、他
    • Journal Title

      European Journal of Nuclear Medicineand Molecular Imaging

      Volume: Vol 38 Pages: 441-450

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of biological aggressiveness assessed by ^<11>C-methionine PET and hypoxic burden assessed by ^<18>F-fluoromisonidazole PET in newly diagnosed glioblastoma2011

    • Author(s)
      Kawai Nobuyuki
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 38 Pages: 441-450

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Respiratory-gated and deep inspiration breath-hold FDG PET/CT for evaluation of pulmonary and abdominal tumors2012

    • Author(s)
      Aga Fumitoshi、 Yamamoto Yuka、 Nishiyama Yoshihiro、他
    • Organizer
      59th annual meeting Society of Nuclear Medicine
    • Place of Presentation
      Miami Beach、Florida、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Simplified procedure for analyzing tumor hypoxia with F-18 fluoromisonidazole PET omitting one venous blood sampling2012

    • Author(s)
      Maeda Yukito 、Yamamoto Yuka 、 Kudomi Nobuyuki 、 Aga Fumitoshi 、 Nishiyama Yoshihiro、他
    • Organizer
      59th annual meeting Society of Nuclear Medicine
    • Place of Presentation
      Miami Beach、Florida、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Respiratory-gated and deep inspiration breath-hold FDG PET/CT protocols for evaluation of pulmonary and abdominal lesions.2012

    • Author(s)
      Aga Fumitoshi
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Miami Beach, Florida
    • Related Report
      2012 Annual Research Report
  • [Presentation] FDG PET/CT respiratory-gating for characterization of pulmonary lesions2011

    • Author(s)
      Aga Fumitoshi、 Yamamoto Yuka、 Nishiyama Yoshihiro 、 他
    • Organizer
      97th scientific assembly and annual meeting Radiological Society of North America
    • Place of Presentation
      Chicago、Illinois、USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Intratumoral FDG metabolic heterogeneity in non-small cell lung cancer2010

    • Author(s)
      Yamamoto Yuka
    • Organizer
      Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, Utah(USA)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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