Development of multi-parametric MRI for preclinical diagnosis of Alzheimer's disease
| Project/Area Number |
22591340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Hiroshi 九州大学, 医学研究院, 教授 (90145433)
HIWATASHI Akio 九州大学, 大学病院, 助教 (30444855)
YAMASHITA Koji 九州大学, 大学病院, 助教 (80546565)
TOGAO Osamu 九州大学, 医学研究院, 助教 (10452749)
OHYAGI Yasumasa 九州大学, 医学研究院, 准教授 (30301336)
MONJI Akira 九州大学, 大学病院, 講師 (00294942)
OHARA Noriyuki 九州大学, 医学研究院, 助教 (20623630)
ARIMURA Hidetaka 九州大学, 医学研究院, 准教授 (20287353)
KUMAZAWA Seiji 九州大学, 医学研究院, 講師 (50363354)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳・神経 / 脳神経疾患 / MRI / アルツハイマー病 / 軽度認知障害 / 認知症 / 脳 |
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| Research Abstract |
We revealed early morphological changes in gray and white matter in mild cognitiveimpairment using voxel-based morphometry (VBM). We developed a novel multi-parametric method by combining VBM and ASL, and showed that our method is superior to each method alone in diagnosing AD. In addition, we developed a high-resolution diffusion tensor imaging method to detect early AD pathology in the hippocampus.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Automated measurement of three-dimensional cerebral cortical thickness in Alzheimer's patients using localized gradient vector trajectory in fuzzy membership maps2013
Author(s)
Tokunaga C, Arimura H, Ohara T, Yamashita Y, Kobayashi K, Magome T, Nakamura Y, Honda H, Hirata H, Ohki M, Toyofuku H
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Journal Title
J Biomed Sci Eng
Volume: 6
Pages: 327-336
Related Report
Peer Reviewed
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[Journal Article] Alzheimer's disease: diagnosis by different methods of voxel-based morphometry2012
Author(s)
Dashjamts T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Ohyagi Y, Monji A, Kamano H, Kawashima T, Kira J, Honda H
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Journal Title
Fukuoka Igaku Zasshi
Volume: 103(3)
Pages: 59-69
NAID
Related Report
Peer Reviewed
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[Presentation] 脳MRIよかろうもん2010
Author(s)
吉浦敬
Organizer
第247回関西NR勉強会・学術講演会
Place of Presentation
千里ライフサイエンスセンター(豊中市)
Year and Date
2010-08-07
Related Report
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