| Project/Area Number |
22591340
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Hiroshi 九州大学, 医学研究院, 教授 (90145433)
HIWATASHI Akio 九州大学, 大学病院, 助教 (30444855)
YAMASHITA Koji 九州大学, 大学病院, 助教 (80546565)
TOGAO Osamu 九州大学, 医学研究院, 助教 (10452749)
OHYAGI Yasumasa 九州大学, 医学研究院, 准教授 (30301336)
MONJI Akira 九州大学, 大学病院, 講師 (00294942)
OHARA Noriyuki 九州大学, 医学研究院, 助教 (20623630)
ARIMURA Hidetaka 九州大学, 医学研究院, 准教授 (20287353)
KUMAZAWA Seiji 九州大学, 医学研究院, 講師 (50363354)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳・神経 / 脳神経疾患 / MRI / アルツハイマー病 / 軽度認知障害 / 認知症 / 脳 |
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| Research Abstract |
We revealed early morphological changes in gray and white matter in mild cognitiveimpairment using voxel-based morphometry (VBM). We developed a novel multi-parametric method by combining VBM and ASL, and showed that our method is superior to each method alone in diagnosing AD. In addition, we developed a high-resolution diffusion tensor imaging method to detect early AD pathology in the hippocampus.
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