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Cardiac sympathetic nerve activity in the non-infarcted region in patients with a prior myocardial infarction and left ventricular remodeling

Research Project

Project/Area Number 22591347
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNagoya City University

Principal Investigator

OHTE Nobuyuki  名古屋市立大学, 大学院・医学研究科, 准教授 (10185332)

Co-Investigator(Kenkyū-buntansha) HARA Masaki  名古屋市立大学, 大学院・医学研究科, 准教授 (50244562)
Research Collaborator IIDA Akihiko  名古屋市総合リハビリテーションセンター, 放射線科部長
NARITA Hitomi  名古屋市総合リハビリテーションセンター, 内科部長
ITO Yoshimaro  名古屋市総合リハビリテーションセンター, 運営企画室放射線取扱主任、診療放射線技師
HAYASHI Emi  名古屋市総合リハビリテーションセンター, 運営企画室, 診療放射線技師
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsPET / 交感神経 / 心筋梗塞
Research Abstract

Left ventricular (LV) remodeling is observed as LV cavity expansion with wall hypertrophy in the remote non-infarcted region in the LVs after myocardial infarction (MI) and is closely involved in systolic heart failure. Accordingly, we assessed the mechanism of this issue from the viewpoint of cardiac sympathetic nerve function in such a region in 16 patients with a prior myocardial infarction using positron emission tomography (PET) and radiolabelled catecholamine analogue 11C-hydroxyephedrine (HED) as a marker for neuronal catecholamine uptake function. HED retention index was determined by normalizing myocardial tracer activity from 30 to 40 minutes to the integral of the 11C activity input function. Cardiac presynaptic catecholamine uptake is known to depend on myocardial blood flow. Thus, we quantitatively measured regional myocardial blood flow (MBF) using PET with 13N-ammonia on the same day. LV volumes were also determined using echocardiography. This study protocol was also do … More ne in 10 healthy volunteers served as normal controls. Results: LV end-diastolic volume index was significantly larger in patients with a prior MI than in normal controls (69.6±15.9 vs 47.2±13.4 ml/m2, p<0.01). An apparent LV remodeling was observed in patients with a prior MI. In normal controls, myocardial blood flow and HED retention index were largest in the LV anterior wall. MBF was significantly less in the remote non-infarcted region in patients with a MI compared with that in the anterior wall in normal controls (0.76±0.14 vs 0.88 ± 0.13 ml/g/min, p<0.05). The retention index of HED (8.06±1.22 vs 7.03 ±1.12 %/min, p<0.01) and the retention index corrected by the blood flow in the corresponding area (10.8± 1.7 vs 8.1± 0.9 %/min/MBF, p<0.001) were significantly higher in the remote non-infarcted region than in the anterior wall of normal controls.Conclusion: A greater amount of sympathetic presynaptic catecholamine uptake is observed in the remote non-infarcted region in patients with a prior MI compared with that in controls. This finding suggests that hyperactivity of myocardial sympathetic nerve function in patients with a prior MI and LV remodeling is related to the pathophysiology of systolic heart failure. Less

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodeling.2012

    • Author(s)
      Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki N, Kimura G
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 39 Issue: 8 Pages: 1246-1253

    • DOI

      10.1007/s00259-012-2138-4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Cardiac sympathetic nerve function in the remote normal region in patients with prior myocardial infarction and left ventricular remodeling.2012

    • Author(s)
      Ohte N, Narita H, Fukuta H, Wakami K, GotoT, Kikuchi S, Kimura G .
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiac Sympathetic Nerve Function in the Remote Normal Region in Patients with Prior Myocardial Infarction and Left Ventricular Remodeling2012

    • Author(s)
      大手信之
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hyperactivity of cardiac sympathetic nerve in the remote normal region in patients with a prior myocardial infarction with left ventricular remodeling.2011

    • Author(s)
      Ohte N, Narita H, Iida A, Fukuta H, WakamiK, Goto T, Tani T, Kimura G .
    • Organizer
      2011 年米国心臓協会年次学術集会
    • Place of Presentation
      米国、オーランド
    • Year and Date
      2011-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Hyperactivity of Cardiac Sympathetic Nerve in the Remote Normal Region in Patients with a Prior Myocardial Infarction with Left Ventricular Remodeling2011

    • Author(s)
      大手信之
    • Organizer
      2011年米国心臓協会年次学術集会
    • Place of Presentation
      米国、オーランド
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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