| Project/Area Number |
22591348
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
YAMADA Kei 京都府立医科大学, 医学研究科, 教授 (80315960)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Tsunehiko 京都府立医科大学, 医学研究科, 教授 (70237733)
SAKAI Koji 京都大学, 医学研究科, 講師 (20379027)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 磁気共鳴画像 / 拡散強調画像 / 拡散テンソル画像 / 中枢神経 / 脳 / q-space imaging / 神経機能 / MRI / 拡散異方性 / DKI / 軸索変性 / CADASIL / magnetic resonance imaging / diffusion kurtosis imaging |
|---|
| Research Abstract |
q-Space imaging is a novel magnetic resonance (MR) technique that enables the assessment of ultrastructural changes of white matter. We hypothesized that thistechnique would facilitate the assessment of the progressive nature of neuronal damage seen in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). q-Space imaging demonstrated early neuronaldamage in a characteristic distribution. Since this method appears to be sensitive to early neuronal damage, it could conceivably aid in monitoring patients in the preclinical stage and may help in assessing the effects of future medical interventions.
|
