Development of diagnostic strategy based on variation of tumormetabolism using nuclear medicine metabolic imaging
| Project/Area Number |
22591351
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Saitama Medical University |
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Principal Investigator |
KUJI Ichiei 埼玉医科大学, 医学部, 准教授 (90283142)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Hiroshi 独立行政法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, センター長 (90173848)
IMABAYASHI Etsuko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 放射線診断科, 医長 (30406491)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 核医学(PETを含む) / 腫瘍代謝多様性 / PET/CT / 18F-フルオロミソニダゾール / 低酸素イメージング / 11C-メチオニン / 脳腫瘍 / 乳癌 / 18F-フルオロデオキシグルコース / ^<18>F-フルオロデオキシグルコース / ^<11>C-メチオニン / ^<18>F-フルオロミソニダゾール |
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| Research Abstract |
We evaluated a metabolic variation of tumors using positron emission tomography. Various metabolic patterns were demonstrated in our studies, and these results should be useful for diagnosis and therapy of various malignant tumors. An early response to radiation and/or chemotherapy was evaluated based on tumor shrinkage using CT images. The FMISO uptake in the tumor had a negative correlation with the tumor shrinkage after therapy. FMISO may be a good predictive indicator for therapy. Breast cancer showed various metabolic patterns, which may correlate with the intrinsic subtypes.
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Report
(4 results)
Research Products
(22 results)
