White matter changes in idiopathic normal pressure hydrocephalus evaluated by diffusion MRI including diffusion tensor and QSI

• Project/Area Number: 22591352
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Juntendo University
• Principal Investigator: AOKI Shigeki 順天堂大学, 医学部, 教授 (80222470)
• Co-Investigator(Kenkyū-buntansha): MIZUSAWA Hidehiro 東京医科歯科大学, 医学部, 教授 (30144091)
• Co-Investigator(Renkei-kenkyūsha): YUASA Tatsuhiko 鎌ヶ谷総合病院, 部長 (10115090)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 正常圧水頭症 / MRI / DTI / 拡散テンソル / diffusion / diffusional kurtosis / Q space imaging / biomarker / Q space imaging QSI / DKI / Q space imaging (QSI) / Diffusional Kurtosis / Kurtosis

Research Abstract

Since histological evaluation of iNPH is difficult, we explored the white matter changes of idiopathic normal pressure hydrocephalus (iNPH) using diffusion analysis of MRI (dMRI). White matter changes related to cognitive decline were observed using diffusion tensor imaging (DTI). The corticospinal tract of iNPH showed diffusional changes due to compression without significant axonal deterioration using DTI. Advanced diffusional MRI (QSI,DKI) showed increased non-Gaussianity consistent with DTI findings. Diffusional MRI might become a unique biomarker of iNPH.

Research Products

• [Journal Article] Relationship between cognitive impairment and white-matter alteration in Parkinson's disease with dementia: tract-based spatial statistics and tract-specific analysis (2013)
  • Author(s): Kamagata K, Motoi Y, Tomiyama H, Abe O, Ito K, Shimoji K, Suzuki M, Hori M, Nakanishi A, Sano T, Kuwatsuru R, Sasai K, Aoki S,Hattori N.
  • Journal Title: Eur Radiol
• [Journal Article] Effects of diffusional kurtosis imaging parameters on diffusion quantification (2013)
  • Author(s): Fukunaga I, Hori M, Masutani Y, Hamasaki N, Sato S, Suzuki Y, Kumagai F, Kosuge M, Hoshito H, Kamagata K, Shimoji K, Nakanishi A, Aoki S,Senoo A
  • Journal Title: Radiol Phys Technol
• [Journal Article] Visualizing non-Gaussian diffusion: clinical application of q-space imaging and diffusional kurtosis imaging of the brain and spine (2012)
  • Author(s): Hori M, Fukunaga I, Masutani Y, Taoka T, Kamagata K, Suzuki Y, Aoki S.
  • Journal Title: Magnetic resonance in medical sciences Volume: 11(4) Pages: 221-33
  • NAID: 10031145222
• [Journal Article] White matter alteration of the cingulum in Parkinson disease with and without dementia: evaluation by diffusion tensor tract-specific analysis (2012)
  • Author(s): Kamagata K, Motoi Y, Abe O, Shimoji K, Hori M, Nakanishi A, Sano T, Kuwatsuru R, Aoki S,Hattori N
  • Journal Title: AJNR Volume: 33(5) Pages: 890-5
• [Journal Article] Different patterns of fornix damage in idiopathic normal pressure hydrocephalus and Alzheimer disease (2012)
  • Author(s): Hattori T, Sato R, Aoki S, Yuasa T, Mizusawa H
  • Journal Title: AJNR Volume: 33(2) Pages: 274-9
• [Journal Article] Cognitive status correlates with white matter alteration in Parkinson's disease (2012)
  • Author(s): Hattori T, Orimo S, Aoki S, Ito K, Abe O, Amano A, Sato R, Sakai K, Mizusawa H
  • Journal Title: Human brain mapping Volume: 33(3) Pages: 727-39
• [Journal Article] White matter alteration in idiopathic normal pressure hydro- cephalus: tract-based spatial statistics study (2012)
  • Author(s): Hattori T, Ito K, Aoki S, Yuasa T, Sato R, Ishikawa M, Sawaura H, Hori M, Mizusawa H
  • Journal Title: AJNR Volume: 33(1) Pages: 97-103
• [Journal Article] Different patterns of fornix damage in idiopathic normal pressure hydrocephalus and Alzheimer disease. (2012)
  • Author(s): Hattori T
  • Journal Title: AJNR Volume: 33 Issue: 2 Pages: 274-279
  • DOI: 10.3174/ajnr.a2780
  • Peer Reviewed
• [Journal Article] White matter alteration in idiopathic normal pressure hydrocephalus: tract-based spatial statistics study. (2012)
  • Author(s): Hattori T
  • Journal Title: AJNR Volume: 33 Issue: 1 Pages: 97-103
  • DOI: 10.3174/ajnr.a2706
  • Peer Reviewed
• [Journal Article] Visualizing Non-Gaussian Diffusion: Clinical Application of q-Space Imaging and Diffusional Kurtosis Imaging of the Brain and Spine (2012)
  • Author(s): Hori M
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 11 Issue: 4 Pages: 221-233
  • DOI: 10.2463/mrms.11.221
  • NAID: 10031145222
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Outcomes of diffusion tensor tractography-integrated stereotactic radiosurgery (2012)
  • Author(s): Koga T, et al
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(2) Pages: 799-802
  • Peer Reviewed
• [Journal Article] Altered Microstructure in Corticospinal Tract in Idiopathic Normal Pressure Hydrocephalus: Comparison with Alzheimer Disease and Parkinson Disease with Dementia (2011)
  • Author(s): Hattori T, Yuasa T, Aoki S, Sato R, Sawaura H, Mori T, Mizusawa H
  • Journal Title: American Journal of Neuroradiology Volume: 32(9) Pages: 1681-7
• [Journal Article] Altered Microstructure in Corticospinal Tract in Idiopathic Normal Pressure Hydrocephalus : Comparison with Alzheimer Disease and Parkinson Disease with Dementia (2011)
  • Author(s): Hattori T, Yuasa T, Aoki S., Mizusawa H.
  • Journal Title: AJNR Volume: 32 Pages: 1681-1687
  • Peer Reviewed
• [Journal Article] MRI拡散テンソル画像:最近の進歩 (2011)
  • Author(s): 青木茂樹、福永一星、堀正明
  • Journal Title: 脳神経外科 Volume: 392 Pages: 935-946
  • Peer Reviewed
• [Journal Article] Diffusion tensor tractography,神経放射線画像の最前線 (2010)
  • Author(s): 青木茂樹, 他
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 531-535
• [Journal Article] Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis. (2010)
  • Author(s): Sato K, Aoki S, et al.
  • Journal Title: Neuroradiology Volume: 52 Pages: 729-33
  • Peer Reviewed
• [Journal Article] Tract-specific analysis for investigation of Alzheimer disease (2010)
  • Author(s): Nakata Y, Aoki S, et al.
  • Journal Title: Jp J Radiol Volume: 28 Pages: 494-501
  • Peer Reviewed
• [Presentation] NPHのQSI/DKI (2011)
  • Author(s): 福永一星、堀正明、青木茂樹
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 小倉
  • Year and Date: 2011-09-30
• [Presentation] Diffusional kurtosis imaging:至適パラメータの検討 (2011)
  • Author(s): 福永一星、堀正明、青木茂樹
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 日本磁気共鳴医学会
  • Year and Date: 2011-09-30
• [Presentation] Q space imaging:至適パラメータの検討 (2011)
  • Author(s): 濱崎望、堀正明、福永一星、青木茂樹
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 日本磁気共鳴医学会
  • Year and Date: 2011-09-30
• [Presentation] Diffusion kurtosis imaging(DKI)の初期使用経験 (2011)
  • Author(s): 堀正明、青木茂樹, 他
  • Organizer: 第40回神経放射線学会
  • Place of Presentation: 品川コンファレンスセンタ
  • Year and Date: 2011-02-24
• [Presentation] Diffusion tensor imaging and its beyond: QSI and DKI
  • Author(s): 青木茂樹
  • Organizer: 日本医学放射線学会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Diffusionalkurtosisimagingを用いた特発性正常圧水頭症の錐体路に関する検討
  • Author(s): 中西淳
  • Organizer: 日本医学放射線学会
  • Place of Presentation: 横浜
• [Presentation] DMRI: from Gaussian to non-Gaussian
  • Author(s): 堀正明
  • Organizer: 日本神経放射線学会
  • Place of Presentation: 小倉
  • Invited