| Project/Area Number |
22591352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Juntendo University |
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Principal Investigator |
AOKI Shigeki 順天堂大学, 医学部, 教授 (80222470)
|
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| Co-Investigator(Kenkyū-buntansha) |
MIZUSAWA Hidehiro 東京医科歯科大学, 医学部, 教授 (30144091)
|
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| Co-Investigator(Renkei-kenkyūsha) |
YUASA Tatsuhiko 鎌ヶ谷総合病院, 部長 (10115090)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 正常圧水頭症 / MRI / DTI / 拡散テンソル / diffusion / diffusional kurtosis / Q space imaging / biomarker / Q space imaging QSI / DKI / Q space imaging (QSI) / Diffusional Kurtosis / Kurtosis |
|---|
| Research Abstract |
Since histological evaluation of iNPH is difficult, we explored the white matter changes of idiopathic normal pressure hydrocephalus (iNPH) using diffusion analysis of MRI (dMRI). White matter changes related to cognitive decline were observed using diffusion tensor imaging (DTI). The corticospinal tract of iNPH showed diffusional changes due to compression without significant axonal deterioration using DTI. Advanced diffusional MRI (QSI,DKI) showed increased non-Gaussianity consistent with DTI findings. Diffusional MRI might become a unique biomarker of iNPH.
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