Early detection of radiation induced apoptosis by 99mTc-Annexin V andFDG in a lung cancer cell line.
| Project/Area Number |
22591357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
KAWA Soukichi 関西医科大学, 医学部, 准教授 (30152896)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Yasuhiro 関西医科大学, 医学部, 助教 (10425069)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アネキシン V / 放射線誘発 / TUNEL 法 / アポトーシス / アネキシンV / TUNEL法 / タリウム201 / ^<99m>Tc-annexin V / ^<201>TlCl |
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| Research Abstract |
^99mTc-HYNIC-coupled Annexin V accumulation with 9 Gy and 12 Gy, doses was found to be higher than in the control and 3-6 Gy irradiated groups at 48 hours post irradiation. Annexin V may prove to be an effective radiotracer for early assessment of radiation therapy efficacy, via apoptosis, in human lung cancers.
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Report
(4 results)
Research Products
(11 results)
