Early detection of radiation induced apoptosis by 99mTc-Annexin V andFDG in a lung cancer cell line.

• Project/Area Number: 22591357
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kansai Medical University
• Principal Investigator: KAWA Soukichi 関西医科大学, 医学部, 准教授 (30152896)
• Co-Investigator(Kenkyū-buntansha): UENO Yasuhiro 関西医科大学, 医学部, 助教 (10425069)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アネキシン V / 放射線誘発 / TUNEL 法 / アポトーシス / アネキシンV / TUNEL法 / タリウム201 / ^<99m>Tc-annexin V / ^<201>TlCl

Research Abstract

^99mTc-HYNIC-coupled Annexin V accumulation with 9 Gy and 12 Gy, doses was found to be higher than in the control and 3-6 Gy irradiated groups at 48 hours post irradiation. Annexin V may prove to be an effective radiotracer for early assessment of radiation therapy efficacy, via apoptosis, in human lung cancers.

Research Products

• [Journal Article] An Investigation of the Early Detection of Radiation Induced Apoptosis by ^99mTc-Annexin V and ²⁰¹Thallium-Chloride in a Lung Cancer Cell Line (2012)
  • Author(s): Khoda ME, Utsunomiya K, Ha-Kawa S,Kanno S, Kono Y, Sawada S.
  • Journal Title: Journal of Radiation Research Volume: 53 Issue: 3 Pages: 361-367
  • DOI: 10.1269/jrr.11177
  • NAID: 130001876855
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] An investigation of the early detection of radiation induced apoptosis by 99mTc-Annexin V and 201Thallium-Chloride in a lung cancer cell line. (2012)
  • Author(s): Khoda Me, Utsunomiya K, Ha-Kawa S, Kanno S, Kono Y, Sawada S.
  • Journal Title: J Radiat Res Volume: 53 Pages: 361-367
  • Peer Reviewed
• [Journal Article] An investigation of the early detection of radiation induced apoptosis by 99mTc-Annexin V and 201Thallium-Chloride in a lung cancer cell line
  • Author(s): ME Khoda, K Utsunomiya, S Ha-Kawa, S Kanno, Y Kohno, S
  • Journal Title: Journal of Radiation Research Volume: (in press)
  • Peer Reviewed
• [Presentation] 放射線照射によるMDR抑制効果と細胞増殖能における経時的変化の検討 (2012)
  • Author(s): 河野由美子、宇都宮啓太、菅野渉平、上埜泰寛、河相吉、澤田敏
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: 横浜市
• [Presentation] 放射線の肺癌細胞におけるMDRと細胞増殖能への影響について (2012)
  • Author(s): 河野由美子、宇都宮啓太、菅野渉平、上埜泰寛、河相吉、谷川昇
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌市
• [Presentation] Time dependent longitudinal effects of radiation-induced suppression of multidrug resistance and cell proliferation potency in a non-small lung cancer cell line. (2012)
  • Author(s): Y. Kono, K. Utsunomiya, S. Kanno, Y. Ueno, S.Ha-Kawa, N. Tanigawa
  • Organizer: European Association of Nuclear Medicine
  • Place of Presentation: Milan, Italy
• [Presentation] 放射線照射によるMDR抑制効果と細胞増殖能における経時的変化の検討 (2012)
  • Author(s): 河野由美子、宇都宮 啓太、菅野 渉平、上埜 泰寛、河 相吉、澤田 敏
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] 放射線の肺癌細胞におけるMDRと細胞増殖能への影響について (2012)
  • Author(s): 河野由美子、宇都宮啓太、菅野渉平、上埜泰寛、河 相吉、谷川 昇
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌(札幌)
• [Presentation] Time dependent longitudinal effects of radiation-induced suppression of multidrug resistance and cell proliferation potency in a non-small lung cancer cell line. (2012)
  • Author(s): Y. Kono, K. Utsunomiya, S. Kanno, Y. Ueno, S. Ha-Kawa, N. Tanigawa
  • Organizer: European Association of Nuclear Medicine
  • Place of Presentation: MiCo - Milano Congressi（Milan）
• [Presentation] Investigation of early detection of radiation induced apoptosis by Tc-99 m Annexin V and T1-201 Chloride in a lung cancer cell line (2010)
  • Author(s): K.Utsunomiya, Y.Harima, S.Ha-Kawa, et al.
  • Organizer: Radiological Society of North America, 2010
  • Place of Presentation: シカゴ(米国)
  • Year and Date: 2010-11-28
• [Presentation] Early detection of radiation induced apoptosis by 99mTc-Annexin V and 201Thallium-Chloride in a lung cancer cell line. (2010)
  • Author(s): S.Ha-Kawa, M.E.Khoda, K.Utsunomiya, S.Sawada
  • Organizer: Annual European Association of Nuclear Medicine, 2010
  • Place of Presentation: ウィーン(オーストラリア)
  • Year and Date: 2010-10-10