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A study for the diagnosis of inflammatory diseases of joint and spine using FDG-PET; prospective and retrospective studies

Research Project

Project/Area Number 22591362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionResearch Institute, International Medical Center of Japan

Principal Investigator

KUBOTA Kazuo  独立行政法人国立国際医療研究センター, 放射線診療部核医学室, 医長 (40161674)

Co-Investigator(Renkei-kenkyūsha) MOROOKA Miyako  国立国際医療研究センター病院, 医師 (90535775)
ITO Kimiteru  国立精神神経センター, 医師 (40602074)
YAMASHITA Hiroyuki  国立国際医療研究センター病院, 医師 (20574172)
MIMORI Akio  国立国際医療研究センター病院, 副院長 (40166111)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords核医学(PET を含む) / FDG-PET / 炎症性疾患 / 関節炎・腱付着部炎 / リウマチ性関節炎 / 強直性脊椎炎 / リウマチ性多発筋痛症 / 加齢変化 / 核医学診断
Research Abstract

We have studied FDG-PET/CT finding of inflammatory diseases of joint and spine. Normal aging effects on the FDG uptake by joints were found to be as minimum as not interfering the diagnosis of disease joints. Polymyalgia rheumatic (PMR) has showed increased FDG uptake in ischial tuberosities, greater trochanters, and lumbar spinous processes characteristically. For the differential diagnosis of seronegative spondyloarthritis (SpA) from PMR, FDG uptake by sacroiliac joints was important.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2013 2012 2011 2010

All Journal Article (14 results) (of which Peer Reviewed: 7 results) Presentation (12 results)

  • [Journal Article] Similarities and differences in fluorodeoxyglucose positron emission tomography/computed tomography findings in spondyloarthropathy, polymyalgia rheumatica and rheumatoid arthritis.2013

    • Author(s)
      Yamashita H, Kubota K, Takahashi Y, Minamimoto R, Morooka M, Kaneko H, Kano T, Mimori A
    • Journal Title

      Joint Bone Spine.

      Volume: 80(2) Pages: 171-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Similarities and differences in FDG-PET/CT findings in spodyloarthropathy, polymyalgia rheumatic and rheumatoid arthritis.2013

    • Author(s)
      Yamashita H, Kubota K, et al
    • Journal Title

      Joint Bone Sine

      Volume: 80(2) Pages: 171-177

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Wegener's granulomatosis using 18F-FDGPET/CT2013

    • Author(s)
      Ito K, Minamimoto R., Kubota K, et al
    • Journal Title

      Annals Nuclear Medicine

      Volume: 27(3) Issue: 3 Pages: 209-216

    • DOI

      10.1007/s12149-012-0675-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body fluorodeoxyglucose positron emission tomography/computed tomography in patients with active polymyalgia rheumatica : evidence for distinctive bursitis and large-vessel vasculitis.2012

    • Author(s)
      Yamashita H, Kubota K, Takahashi Y, Minaminoto R, Morooka M, Ito K, Kano T, Kaneko H,Takashima H, Mimoiri A
    • Journal Title

      Mod Rheumatol

      Volume: 22(5) Pages: 705-11

    • NAID

      10031027761

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inflammation surrounding the vertebral spinous processes as spondylarthritis in Behcet's disease.2012

    • Author(s)
      Yamashita H, Kubota K, Takahashi Y, Kaneko H, Kano T, Mimori A
    • Journal Title

      Mod Rheumatol

      Volume: (Epub ahead of print)

    • NAID

      10031189180

    • Related Report
      2012 Final Research Report
  • [Journal Article] A case of gouty arthritis to tophi on 18F-FDG PET/CT imaging2012

    • Author(s)
      Ito K, Minamimoto R, Morooka M, Kubota K
    • Journal Title

      Clin Nucl Med

      Volume: 37(6) Pages: 614-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inflammation surrounding the vertebralspinous processes as spondylarthritis in Behcet's disease.2012

    • Author(s)
      Yamashita H, Kubota K, et al
    • Journal Title

      Modern Rheumatology

      Volume: Jul14Epub Issue: 4 Pages: 823-826

    • DOI

      10.1007/s10165-012-0713-y

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FDG PET for rheumatoid arthritis : basic considerations and whole-body PET/CT.2011

    • Author(s)
      Kubota K, Ito K, Morooka M, Minamimoto R, Miyata Y, Yamashita H, Takahashi Y, Mimori A
    • Journal Title

      Ann N Y Acad Sci.

      Volume: 1228 Pages: 29-38

    • Related Report
      2012 Final Research Report
  • [Journal Article] FDG PET for rheumatoid arthritis : basic considerations and whole-body PET/CT2011

    • Author(s)
      Kubota K., Ito K, Morooka M, et al
    • Journal Title

      Ann N Y AcadSci

      Volume: 1228 Issue: 1 Pages: 29-38

    • DOI

      10.1111/j.1749-6632.2011.06031.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body fluorodeoxyglucose positron emission tomography/computed tomography in patients with active polymyalgia rheumatica : evidence for distinctive bursitis and large-vessel vasculitis2011

    • Author(s)
      Yamashita H., Kubota K., Takahashi Y., et al
    • Journal Title

      Mod Rheumatol

      Volume: (On Line)

    • NAID

      10031027761

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 関節疾患の画像診断;核医学2011

    • Author(s)
      窪田和雄, 他5名
    • Journal Title

      整形・災害外科

      Volume: 54 Pages: 491-498

    • Related Report
      2010 Annual Research Report
  • [Journal Article] FDG-PET for rheumatoid arthritis ; basic considerations and whole-body PET/CT2011

    • Author(s)
      Kubota K, Ito K, Morooka M, et al
    • Journal Title

      Annals of New York Academy of Science

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of (18)F-FDG PET/CT on the management and diagnosis of infectious spondylitis.2010

    • Author(s)
      Ito K, Kubota K, Morooka M, Hasuo K, Kuroki H, Mimori A
    • Journal Title

      Nucl Med Commun

      Volume: 31(8) Pages: 691-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clinical impact of (18)F-FDG PET/CT on the management and diagnosis of infectious spondylitis2010

    • Author(s)
      Ito K, Kubota K, Morooka M, et al
    • Journal Title

      Nuclear Medicine Communication

      Volume: 31 Pages: 691-698

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血清陰性脊椎関節炎、リウマチ性多発筋痛症、関節リウマチの3 疾患におけるFDG-PET/CT 画像所見の類似点と相違点2012

    • Author(s)
      山下裕之、窪田和雄、高橋裕子、金子礼志、狩野俊和、三森明夫
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節リウマチ、リウマチ性多発筋痛症、血清陰性脊椎関節炎の3 疾患におけるFDG-PET/CT 画像所見の特徴2012

    • Author(s)
      山下裕之
    • Organizer
      PET サマーセミナーin 信州
    • Place of Presentation
      松本
    • Related Report
      2012 Final Research Report
  • [Presentation] FDG-PET for Imaging of Inflammation.2012

    • Author(s)
      Kazuo Kubota
    • Organizer
      SNM 2012 Mid-Winter Meeting
    • Place of Presentation
      Orland, Florida USA
    • Related Report
      2012 Final Research Report
  • [Presentation] FDG-PET/CTにおけるWegener肉芽腫症の活動性評価。札幌。2012

    • Author(s)
      伊藤公輝、窪田和雄、他
    • Organizer
      第52回日本核医学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺がんから炎症へ、糖代謝からDNAへ2011

    • Author(s)
      窪田和雄
    • Organizer
      第7回愛知PET臨床利用研究会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] PETはもっと役に立つ!新しい使い方と展望2011

    • Author(s)
      窪田和雄
    • Organizer
      第28回三重総合画像研究会
    • Place of Presentation
      三重県津市
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節・腱付着部のFDG 集積:健常人の加齢変化について2011

    • Author(s)
      窪田和雄、南本亮吾、諸岡都、岡崎百子、伊藤公輝、宮田陽子、三本拓也、佐藤敬
    • Organizer
      第51回日本核医学会
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] 18F-FDG-PET/CT で同定されたリウマチ性多発筋痛症における腱付着部炎の重要性2011

    • Author(s)
      山下裕之、窪田和雄、高橋裕子、金子礼志、三森明夫
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節・腱付着部のFDG集積:健常人の加齢変化について2011

    • Author(s)
      窪田和雄、南本亮吾、諸岡都, 他
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      茨城県つくば市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 嗄声を生じた患者におけるFDG-PET/CTの有用性の検討2011

    • Author(s)
      南本亮吾、窪田和雄、諸岡都, 他
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      茨城県つくば市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多発性骨髄腫のFDG-PET、メチオニンPET、チミジンPETの比較検討2011

    • Author(s)
      岡崎百子、窪田和雄、諸岡都, 他
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      茨城県つくば市
    • Related Report
      2011 Annual Research Report
  • [Presentation] FDG集積の生化学的、生物学的背景2011

    • Author(s)
      窪田和雄
    • Organizer
      第11回日本核医学会春季大会PET研修セミナー
    • Place of Presentation
      大阪市
    • Related Report
      2011 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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