Development and evaluation of quantification for BF-227 amyloid PET imaging.
| Project/Area Number |
22591364
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
KATO Takashi 独立行政法人国立長寿医療研究センター, 脳機能画像診断開発部, 室長 (60242864)
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| Co-Investigator(Kenkyū-buntansha) |
SIDAHARA Miho 東北大学, 医学(系)研究科(研究院), 講師 (20443070)
ITO Kengo 独立行政法人国立長寿医療研究センター, 脳機能画像診断開発部, 部長 (70184653)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIWARA Ken 独立行政法人国立長寿医療研究センター, 脳機能画像診断開発部, 研究生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 放射線 / 脳 / 神経 / 脳神経疾患 / 臨床 / 痴呆 / アミロイドイメージング / 部分容積効果 / 脳・神経 |
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| Research Abstract |
The purpose of this study was to establish a method for evaluating quantitatively BF-227 amyloid PET. Spatial normalization using BF-227 template showed equal to or higher precision than spatial normalization using MRI template. The new method proposed in this study to determine cerebellar reference region is useful for making SUVR (standard uptake value ratio) image for BF-227 PET. Partial volume correction with resolution recovery did not discriminate the accumulation between the cortex and white matter. Further improvement of algorithm is necessary. The methods proved to be useful for BF-227 PET can be applied to other amyloid imaging tracers.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Evaluation of the biodistribution and radiation dosimetry of the F-18 labelled amyloid imaging probe [18F]FACT in humans.2013
Author(s)
Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Yanai K
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Journal Title
EJNMMI res.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Quantification of opioid receptor availability following spontaneous epileptoc seizures: Correction of [11C]diprenorphine PET data for the partial-volume effect.2013
Author(s)
McGinnity CJ, Shidahara M, Feldmann M, Keihaninejad S, Barros DA, Gousias IS, Duncan JS, Brooks DJ, Heckemann RA, Turkheimer FE, Hammers A, Koepp MJ
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Journal Title
Neuroimage.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Japanese Alzheimer's Disease Neuroimaging Initiative.Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study2013
Author(s)
Takahashi R, Ishii K, Senda M, Ito K, Ishii K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T
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Journal Title
Ann Nucl Med.
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Evaluation of the biodistribution and radiation dosimetry of the F-18 labelled amyloid imaging probe [18F]FACT in humans.2013
Author(s)
Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Yanai K
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Quantification of opioid receptor availability following spontaneous epileptoc seizures: Correction of [11C]diprenorphine PET data for the partial-volume effect.2013
Author(s)
McGinnity CJ, Shidahara M, Feldmann M, Keihaninejad S, Barros DA, Gousias IS, Duncan JS, Brooks DJ, Heckemann RA, Turkheimer FE, Hammers A, Koepp MJ
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study2013
Author(s)
Takahashi R, Ishii K, Senda M, Ito K, Ishii K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T,Japanese Alzheimer’s Disease Neuroimaging Initiative.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Presentation] Influence of APOE Genotype on Global and Regional Amyloid Deposition: Results from Three WW-ADNI [C-11]PiB Data2012
Author(s)
Kenji Ishii, Eisuke Haneda, Muneyuki Sakata, Keiichi Oda, Jun Toyohara, Kiichi Ishiwata, Michio Senda, Kengo Ito, Ryozo Kuwano, Takeshi Iwatsubo
Organizer
Alzheimer’s Association International Conference (AAIC 2012)
Place of Presentation
Vancouver, British Columbia, Canada
Related Report
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[Presentation] Effects of ApoE epsilon 4 on Regional Cerebral Amyloid Deposition and Glucose Metabolism in Amnestic Mild Cognitive Impairment with Amyloid Pathology Confirmed by PiB PET: Results from J-ADNI2012
Author(s)
Ryuichi Takahashi, Kazunari Ishii, Michio Senda, Kengo Ito, Kenji Ishii, Takashi Kato, Morihiro Sugishita, Ryozo Kuwano, Takeshi Iwatsubo
Organizer
Alzheimer’s Association International Conference (AAIC 2012)
Place of Presentation
Vancouver, British Columbia, Canada
Related Report
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[Presentation] Differences in Regional Cerebral Glucose Metabolism between PiB Positive and Negative Amnestic Mild Cognitive Impairment: Results from J-ADNI2012
Author(s)
Kazunari Ishii, Ryuichi Takahashi, Michio Senda, Kengo Ito, Kenji Ishii, Takashi Kato, Morihiro Sugishita, , Takeshi Iwatsubo, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI)
Organizer
Alzheimer’s Association International Conference (AAIC 2012)
Place of Presentation
Vancouver, British Columbia, Canada
Related Report
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