The Effect of intra-vertebral injection of Bisphosphonate: An Experimental Study in an Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation
| Project/Area Number |
22591367
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Kan 三重大学, 医学部附属病院, 病院長 (70106988)
YAMAKADO Koichiro 三重大学, 医学部附属病院, 准教授 (20263022)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | ラジオ波焼灼術・ / 椎体形成術 / 骨粗鬆症 / マイクロCT・ビスフォスフォネート / radiofrequency ablation / rabbit spine model / bone strength / micro CT / bisphosphonate / intravertebral injection / osteoporosis / histopathology / rabbit lumber spine model / bisphosponate / osteporosis / rabbit lumbar spine model / intra-vertebral injection |
|---|
| Research Abstract |
Bone strength in ablated lumbar spines was significantly fragile as compared with control group due to bony microarchitectural destruction of the trabeculae. Both effects of intra-venous and intra-vertebral injection of Bisphosphonate were found to be similar in changing in both bone strength and bony micro-architecture.
|
Report
(4 results)
Research Products
(9 results)
