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The Effect of intra-vertebral injection of Bisphosphonate: An Experimental Study in an Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation

Research Project

Project/Area Number 22591367
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionMie University

Principal Investigator

NAKATSUKA Atsuhiro  三重大学, 医学部附属病院, 助教 (70303740)

Co-Investigator(Kenkyū-buntansha) TAKEDA Kan  三重大学, 医学部附属病院, 病院長 (70106988)
YAMAKADO Koichiro  三重大学, 医学部附属病院, 准教授 (20263022)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsラジオ波焼灼術・ / 椎体形成術 / 骨粗鬆症 / マイクロCT・ビスフォスフォネート / radiofrequency ablation / rabbit spine model / bone strength / micro CT / bisphosphonate / intravertebral injection / osteoporosis / histopathology / rabbit lumber spine model / bisphosponate / osteporosis / rabbit lumbar spine model / intra-vertebral injection
Research Abstract

Bone strength in ablated lumbar spines was significantly fragile as compared with control group due to bony microarchitectural destruction of the trabeculae. Both effects of intra-venous and intra-vertebral injection of Bisphosphonate were found to be similar in changing in both bone strength and bony micro-architecture.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Changes in Bone Structure and Strength following Radiofrequency Ablation with and without Vertebroplasty2013

    • Author(s)
      Atsuhiro Nakatsuka, Koichiro Yamakado
    • Journal Title

      an ex vivo Study in Swine Spine Journal of Biomedical Science and Engineering

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 増骨剤の治療効果に関する生体力学的評価2011

    • Author(s)
      上田 怜, 中塚豊真, 稲葉忠司
    • Journal Title

      三重大学工学部修士論文集

    • Related Report
      2012 Final Research Report
  • [Journal Article] 増骨剤の治療効果に関する生体力学的評価2011

    • Author(s)
      上田 怜, 中塚豊真, 稲葉忠司, 他
    • Journal Title

      平成22年度 三重大学工学部工学研究科(博士前期課程)研究領域Dライフサイエンス修士論文集

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
  • [Presentation] 兎の腰椎におけるRFA後のビスホスホネートの効果に関する実験的検討2013

    • Author(s)
      中塚豊真、山門亨一郎
    • Organizer
      本INTERVENTIONAL RADIOLOGY学会第32回中部・第31回関西合同地方会
    • Place of Presentation
      大阪府、大阪市北区堂島、ホテルエルセラーン大阪
    • Year and Date
      2013-02-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 兎の腰椎におけるRFA後のビスホスホネートの効果に関する実験的検討2012

    • Author(s)
      中塚豊真、山門亨一郎, 他6名
    • Organizer
      日本INTERVENTIONAL RADIOLOGY学会第32回中部・第31回関西合同地方会
    • Place of Presentation
      大阪府、大阪市北区堂島ホテルエルセラーン大阪
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of Intra-venous Versus Intra-vertebral Injection of Bisphosphonate in an Rabbit Lumbar Spine Model weakened by Radiofrequency Ablation: Changes in Physical Properties and Micro CT-Histopathologic Correlation2011

    • Author(s)
      Atsuhiro Nakatsuka, Koichiro Yamakado, Kan Takeda
    • Organizer
      第97回北米放射線科学会(97th Annual Meeting
    • Place of Presentation
      米国、シカゴ、マコーミックプライス・コンベンションセンター
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation; Evaluation of Physical Properties and Micro CTHistopathologicCorrelation2011

    • Author(s)
      Atsuhiro Nakatsuka, Koichiro Yamakado, Ray Ueda, Kan Takeda
    • Organizer
      2011 Society of Interventional Radiology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation ; Evaluation of Physical Properties and Micro CT-Histopathologic Correlation2011

    • Author(s)
      Atsuhiro Nakatsuka, Koichiro Yamakado, Ray Ueda, Kan Takeda, et al.
    • Organizer
      2011 Society of Interventional Radiology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of Intra-venous Versus Intra-vertebral Injection of Bisphosphonate in an Rabbit Lumbar Spine Model weakened by Radiofrequency Ablation : Changes in Physical Properties and Micro CT-Histopathologic Correlation2011

    • Author(s)
      Atsuhiro Nakatsuka, Koichiro Yamakado, Kan Takeda, et al
    • Organizer
      第97回北米放射線科学会(97th Annual Meeting, Radiological Society of North America)
    • Place of Presentation
      米国、シカゴ、マコーミックプライス・コンベンションセンター
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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