| Project/Area Number |
22591367
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Kan 三重大学, 医学部附属病院, 病院長 (70106988)
YAMAKADO Koichiro 三重大学, 医学部附属病院, 准教授 (20263022)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ラジオ波焼灼術・ / 椎体形成術 / 骨粗鬆症 / マイクロCT・ビスフォスフォネート / radiofrequency ablation / rabbit spine model / bone strength / micro CT / bisphosphonate / intravertebral injection / osteoporosis / histopathology / rabbit lumber spine model / bisphosponate / osteporosis / rabbit lumbar spine model / intra-vertebral injection |
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| Research Abstract |
Bone strength in ablated lumbar spines was significantly fragile as compared with control group due to bony microarchitectural destruction of the trabeculae. Both effects of intra-venous and intra-vertebral injection of Bisphosphonate were found to be similar in changing in both bone strength and bony micro-architecture.
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