Radio-enhancement effects by Parthenolide, NF-κB inhibitor, and analysis of these molecular mechanism.
| Project/Area Number |
22591381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Hideki 福井大学, 高エネルギー研究センター, 准教授 (40142377)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | NF-κB 阻害剤 / パルテノライド / Apoptosis / ras/raf/MAPK / DU145 細胞 / NF-κB阻害剤 / DU145細胞 / PC3細胞 |
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| Research Abstract |
PTL showed significant radio- and thermo-sensitization in human prostate cancer cells. It was suggested that lethal damage of cells was due to the induction of apoptosis or G2M cell cycle arrest via the 3 cascades to Ras/Raf/MAPK signaling upstream of NF-κB.
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Report
(4 results)
Research Products
(15 results)
