Efficacy of donepezil HCl to higher brain dysfunction after radiation therapy

• Project/Area Number: 22591384
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: SASAKI Ryohei 神戸大学, 医学部附属病院, 特命教授 (30346267)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Yasuji 神戸大学, 医学部付属病院, 講師 (00324921) ; 西原 賢在 神戸大学, 医学研究科, 医学研究員 (20452493)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 塩酸ドネべジル / 放射線治療 / 高次脳機能 / 塩酸ドネベジル / 有害反応 / 塩酸ドネペジル / 高次脳機能低下

Research Abstract

We peformed clinical trials against higher brain dysfunction after radiation therapy. Among this period, 4 cases were enrolled in this study. There were a patient with glioblastoma, a patient with low grade glioma, a patients with CNS lymphoma, and a patient with metastatic brain tumor. There were 3 male and 1 female patients. They were 30, 67, 72 years old, respectively. Radiation fields were set as whole brain irradiation in 2 patients, and localized fields in other 2 patients. Radiation doses were ranging from 30-60 Gy. Efficacy of donepezil HCl were observed in all cases. There were no case who experienced more than Grade 2 morbidity. In conclusion, donepezil HCl seemed to be effective and safe treatment option against higher brain dysfunction after radiation therapy

Research Products

• [Journal Article] Long-Term Outcome of Proton Therapy and Carbon-Ion Therapy for Large (T2a-T2bN0M0) Non-Small-Cell Lung Cancer (2013)
  • Author(s): Iwata H, Demizu Y, Fujii O, Terashima K, Mima M, Niwa Y, Hashimoto N, Akagi T, Sasaki R,Hishikawa Y, Abe M, Shibamoto Y, Murakami M, Fuwa N
  • Journal Title: J Thorac Oncol Volume: Epub ahead of print Issue: 6 Pages: 726-35
  • DOI: 10.1097/jto.0b013e318288ab02
  • Peer Reviewed
• [Journal Article] Radiotherapy for Stage I or II hypopharyngeal carcinoma (2012)
  • Author(s): Nishimura H, Sasaki R, Yoshida K, Miyawaki D, Okamoto Y, Kiyota N, Saito M, Otsuki N, Nibu KI
  • Journal Title: J Radiat Res Volume: 53(6) Pages: 892-9
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• [Journal Article] Efficacy of intraoperative radiotherapy targeted to the abdominal lymph node area in patients with esophageal carcinoma (2012)
  • Author(s): Tamaki Y, Sasaki R, Ejima Y, Ogura M, Negoro Y, Nakajima T, Murakami M, Kaji Y, Sugimura K
  • Journal Title: J Radiat Res Volume: Nov 1;53(6) Pages: 882-91
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• [Journal Article] Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index (2012)
  • Author(s): Uehara K, Sasayama T, Miyawaki D, Nishimura H, Yoshida K, Okamoto Y, Mukumoto N, Akasaka H, Nishihara M, Fujii O, Soejima T, Sugimura K, Kohmura E, Sasaki R
  • Journal Title: Radiat Oncol Volume: 7 Pages: 104-104
  • Peer Reviewed
• [Journal Article] A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis (2012)
  • Author(s): Terashima K, Demizu Y, Hashimoto N, Jin D, Mima M, Fujii O, Niwa Y, Takatori K, Kitajima N, Sirakawa S, Yonson K, Hishikawa Y, Abe M, Sasaki R, Sugimura K, Murakami M
  • Journal Title: Radiother Oncol Volume: 103(1) Pages: 25-31
  • Peer Reviewed
• [Journal Article] Sugimura K.Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy (2012)
  • Author(s): Hashimoto N, Sasaki R, Nishimura H, Yoshida K, Miyawaki D, Nakayama M, Uehara K, Okamoto Y, Ejima Y, Azumi A, Matsui T
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(4) Pages: 1509-14
  • Peer Reviewed
• [Journal Article] Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated with Curative Radiotherapy (2012)
  • Author(s): Sasaki R, Yasuda K, Abe E, Uchida N, Kawashima M, Uno T, Fujiwara M, Shioyama Y, Kagami Y, Shibamoto Y, Nakata K, Takada Y, Kawabe T, Uehara K, Nibu K, Yamada S.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(2) Pages: 626-34
  • Peer Reviewed
• [Journal Article] Long-term outcome of hypofractionated radiotherapy to the whole breast of Japanese women after breast-conserving surgery (2012)
  • Author(s): Ishihara T, Yoden E, Konishi K, Nagase N, Yoshida K, Kurebayashi J, Sonoo H, Murashima N, Sasaki R, Hiratsuka J
  • Journal Title: Breast Cancer
  • Peer Reviewed
• [Journal Article] Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy. (2012)
  • Author(s): Sasaki R
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 82(2) Issue: 2 Pages: 626-634
  • DOI: 10.1016/j.ijrobp.2010.11.037
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• [Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy. (2012)
  • Author(s): Hashimoto N
  • Journal Title: 10.1016/j.ijrobp.2011.04.052 Volume: 82(4) Pages: 1509-14
  • Peer Reviewed
• [Journal Article] Patterns of failure after multimodal treatments for high-grade glioma: (2012)
  • Author(s): Uehara K
  • Journal Title: Radiat Oncol Volume: 26 Issue: 1 Pages: 104-104
  • DOI: 10.1186/1748-717x-7-104
  • Peer Reviewed
• [Journal Article] Efficacy of intraoperative radiotherapy targeted to the abdominal (2012)
  • Author(s): Tamaki Y
  • Journal Title: J Radiat Res. Volume: 53(6) Issue: 6 Pages: 882-891
  • DOI: 10.1093/jrr/rrs045
  • Peer Reviewed
• [Journal Article] Radiotherapy for stage I or II hypopharyngeal carcinoma. (2012)
  • Author(s): Nishimura H,
  • Journal Title: J Radiat Res. Volume: 53(6) Issue: 6 Pages: 892-899
  • DOI: 10.1093/jrr/rrs044
  • Peer Reviewed
• [Journal Article] Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells. (2012)
  • Author(s): Akasaka H,
  • Journal Title: Biochim Biophys Acta. Volume: 1830(3) Issue: 3 Pages: 2517-2525
  • DOI: 10.1016/j.bbagen.2012.11.004
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• [Journal Article] A case of squamous cell carcinoma with pagetoid features in the oral mucosa. (2012)
  • Author(s): SHIBUYA Y
  • Journal Title: Hospital Dentistry & Oral-Maxillofacial Surgery Volume: 24(2) Pages: 63-68
  • Peer Reviewed
• [Journal Article] Long-term outcome of hypofractionated radiotherapy to the whole breast of Japanese women after breast-conserving surgery (2012)
  • Author(s): Ishihara T
  • Journal Title: Breast Cancer Volume: F22 Pages: 0-0
  • Peer Reviewed
• [Journal Article] A phase I/II study of gemcitabine-concurrent proton radiotherapy for locally advanced pancreatic cancer without distant metastasis. (2012)
  • Author(s): Terashima K
  • Journal Title: Radiother Oncol. Volume: 103(1) Issue: 1 Pages: 25-31
  • DOI: 10.1016/j.radonc.2011.12.029
  • Peer Reviewed
• [Journal Article] Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma (2011)
  • Author(s): Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Sasaki R, Hori Y, Hishikawa Y, Ku Y, Murakami M
  • Journal Title: Cancer Volume: 117(21) Pages: 4890-904
  • Peer Reviewed
• [Journal Article] Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity. (2011)
  • Author(s): Yoshida K, Sasaki R, Nishimura H, Miyawaki D, Kawabe T, Okamoto Y, Nakabayashi K, Yoshida S, Sugimura K
  • Journal Title: Arch Gynecol Obstet Volume: 284(4) Pages: 1007-14
  • Peer Reviewed
• [Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus (2011)
  • Author(s): Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Niwa Y, Mima M, Fujii O, Sasaki R, Yamada I, Hori Y, Hishikawa Y, Abe M, Ku Y, Murakami M.
  • Journal Title: J Gastroenterol Volume: 46(7) Pages: 913-20
  • NAID: 10029313291
  • Peer Reviewed
• [Journal Article] 耳下腺癌における予防的頸部郭清と術後放射線治療について (2011)
  • Author(s): 柴田智久,米澤宏一郎, 森本浩一,山下大介, 大月直樹, 西村英輝, 佐々木良平, 丹生健一
  • Journal Title: 頭頸部癌 Volume: 37巻 1号 Pages: 1349-5747
  • NAID: 10030814927
  • Peer Reviewed
• [Journal Article] 局所進行下咽頭癌に対する術後放射線療法の遡及的検討 (2011)
  • Author(s): 西村英輝, 佐々木良平, 吉田賢史,宮脇大輔, 大月直樹, 斉藤幹, 清田尚臣, 副島俊典, 杉村和朗, 丹生健一
  • Journal Title: 頭頸部癌 Volume: 37巻 1号 Pages: 62-66
  • NAID: 10030814868
  • Peer Reviewed
• [Journal Article] Radiation therapy in patients with implanted cardiac pacemakers and implantable cardioverter defibrillators: a prospective survey in Japan (2011)
  • Author(s): Soejima T, Yoden E, NIshimura Y, Ono S, Yoshida A, Fukuda H, Fukuhara N, Sasaki R, Tsujino K, Norihisa Y
  • Journal Title: J Radiat Res Volume: 52(4) Pages: 516-21
  • NAID: 10029122393
  • Peer Reviewed
• [Journal Article] 放射線治療の有害事象 (2011)
  • Author(s): 佐々木良平,橋本直樹,赤坂浩亮
  • Journal Title: プロフェッショナルがんナーシング Volume: 1 Pages: 63-73
  • Peer Reviewed
• [Journal Article] がん放射線治療の基礎知識 (2011)
  • Author(s): 佐々木良平, 西村英輝,椋本成俊
  • Journal Title: プロフェッショナルがんナーシング Volume: 1 Pages: 42-55
  • Peer Reviewed
• [Journal Article] Radiotherapy for Japanese elderly patients with cervical cancer : preliminary survival outcomes and evaluation of treatment-related toxicity (2011)
  • Author(s): Yoshida K
  • Journal Title: Arch Gynecol Obstet Volume: 284(4) Issue: 4 Pages: 1007-1014
  • DOI: 10.1007/s00404-010-1777-6
  • Peer Reviewed
• [Journal Article] Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated with Curative Radiotherapy (2011)
  • Author(s): Sasaki R
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(2) Pages: 626-634
  • Peer Reviewed
• [Journal Article] Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma (2011)
  • Author(s): Komatsu S
  • Journal Title: Cancer Volume: 117(21) Pages: 4890-4894
  • Peer Reviewed
• [Journal Article] Radiation Therapy in Patients with Implanted Cardiac Pacemakers and Implantable Cardioverter Defibrillators : A Prospective Survey in Japan (2011)
  • Author(s): Soejima T
  • Journal Title: J Radiat Res Volume: 52(4) Pages: 516-521
  • Peer Reviewed
• [Journal Article] Long-Term Outcome and Patterns of Failure in Primary Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma Treated with Radiotherapy (2011)
  • Author(s): Hashimoto N
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(4) Pages: 1509-1514
  • Peer Reviewed
• [Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus (2011)
  • Author(s): Komatsu S
  • Journal Title: J Gastroenterol Volume: 46(7) Pages: 913-920
  • Peer Reviewed
• [Journal Article] Oncocytic Carcinoid of the Kidney Positively Detected by I-131 MIBG Scintigraphy (2011)
  • Author(s): Tamaki Y
  • Journal Title: Clin Nucl Med Volume: 36 Pages: 1025-28
  • Peer Reviewed
• [Journal Article] Histiocytic sarcoma with two immunohistopathologically distinct populations (2011)
  • Author(s): Wakahashi K
  • Journal Title: Int J Hematol Volume: 92(4) Pages: 642-646
  • Peer Reviewed
• [Journal Article] 局所進行下咽頭癌に対する術後放射線療法の遡及的検討 (2011)
  • Author(s): 西村英輝
  • Journal Title: 頭頸部癌 Volume: 37 Pages: 62-66
  • Peer Reviewed
• [Journal Article] 耳下腺癌における予防的頸部敦清と術後放射線治療について (2011)
  • Author(s): 柴田智久
  • Journal Title: 頭頸部癌 Volume: 117(21) Pages: 78-82
  • Peer Reviewed
• [Journal Article] 【治療に伴う看護特集一問一答でいちからわかる、きちんとわかる!がん放射線療法と看護】一問一答で"きちんと"わかる。がん放射線治療の基礎知識 (2011)
  • Author(s): 佐々木良平
  • Journal Title: プロフェッショナルがんナーシング Volume: 1 Pages: 42-55
  • Peer Reviewed
• [Journal Article] 【治療に伴う看護特集一問一答でいちからわかる、きちんとわかる!がん放射線療法と看護】患者説明のための見通しを知ろう。放射線治療の有害事象 (2011)
  • Author(s): 佐々木良平
  • Journal Title: プロフェッショナルがんナーシング Volume: 1 Pages: 63-73
  • Peer Reviewed
• [Journal Article] Predictive Value of (18)F-Fluorodeoxyglucose Uptake by Positron Emissi on Tomography for Non-Small Cell Lung Cancer Patients Treated with Radical Radiotherapy. (2011)
  • Author(s): Ikushima H
  • Journal Title: J Radiat Res. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Histiocytic sarcoma with two immunohistopathologically distinct populations. (2011)
  • Author(s): Wakahashi K
  • Journal Title: Int J Hematol. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Multi-institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated with Curative Radiotherapy. (2011)
  • Author(s): Ryohei Sasaki
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: (In press)
  • Peer Reviewed
• [Journal Article] Radiotherapy for Japanese elderly patients with cervical cancer : preliurinary survival outcomes and evaluation of treatment-related toxicity. (2011)
  • Author(s): Shohei Komatsu
  • Journal Title: Cancer Volume: (In press)
  • Peer Reviewed
• [Journal Article] The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation (2010)
  • Author(s): Mukubou H, Tujimura T, Sasaki R, Yonson Ku
  • Journal Title: International Journal of Oncology Volume: 37(4) Pages: 821-8
  • Peer Reviewed
• [Journal Article] Suzuki, Miki Saitoh, Naoki Otsuki, Yoshitake Hayashi, Toshinori Soejima, Kenichi Nibu, and Kazuro Sugimura (2010)
  • Author(s): Kenji Yoshida, Ryohei Sasaki,Hideki Nishimura, Yoshiaki Okamoto, Yoko
  • Journal Title: Nuclear Factor-kappa B Expression as a Novel Marker of Radioresistance: In Early Stage Laryngeal Cancer, Head Neck. Volume: 32(5) Issue: 5 Pages: 646-55
  • DOI: 10.1002/hed.21239
  • Peer Reviewed
• [Journal Article] Vitamin K2-derived Compounds Induce Growth Inhibition in Radioresistant Cancer Cells (2010)
  • Author(s): Amalia H, Sasaki R,Suzuki Y, Demizu Y, Bito T, Nishimura H, Okamoto Y, Yoshida K, Miyawaki D, Kawabe T, Mizushina Y, and Kazuro S
  • Journal Title: Kobe J Med Sci Volume: 56(2) Pages: 38-49
  • NAID: 110007670720
  • Peer Reviewed
• [Journal Article] Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor (2010)
  • Author(s): Y. Kumamoto-Yonezawa, R. Sasaki, Y. Suzuki, Y. Matsui, T. Hada, K. Uryu, K. Sugimura, H. Yoshida, Y. Mizushina.
  • Journal Title: International Journal of Oncology Volume: 36 Pages: 577-584
  • Peer Reviewed
• [Journal Article] PET診断と放射線治療 (2010)
  • Author(s): 佐々木良平
  • Journal Title: PET Journal Volume: 10 Pages: 13-15
• [Journal Article] Enhancement of human cancer cell radiosensitivity by conjugated eicosa pentaenoic acid-a mammalian DNA polymerase inhibitor. (2010)
  • Author(s): Kumamoto-Yonezawa Y
  • Journal Title: Int.J.Oncol Volume: 36(3) Pages: 577-584
  • Peer Reviewed
• [Journal Article] Vitamin K2-derived Compounds Induce Growth Inhibition in Radioresistant Cancer Cells. (2010)
  • Author(s): Amalia H
  • Journal Title: Kobe J Med Sci Volume: 56(2) Pages: 38-49
  • Peer Reviewed
• [Journal Article] The role of autophagy in the treatment of pancreatic cancer with gemci tabine and ionizing radiation. (2010)
  • Author(s): Mukubou H
  • Journal Title: International Journal of Oncology Volume: 37(4) Pages: 821-828
  • Peer Reviewed
• [Journal Article] Arch Gynecol Obstet. (2010)
  • Author(s): Yoshida K
  • Journal Title: Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma Volume: (In press)
  • Peer Reviewed
• [Journal Article] PET診断と放射線治療 (2010)
  • Author(s): 佐々木良平
  • Journal Title: PETジャーナル Volume: 10 Pages: 13-15
• [Presentation] Radiotherapy for Japanese elderly patients with cervical cancer (2013)
  • Author(s): Yoshida K
  • Organizer: European Congress of Radiology（ECR)
  • Place of Presentation: Vienna, Austria
• [Presentation] Ten Year Experience with Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Oropharynx (2013)
  • Author(s): Miyawaki D
  • Organizer: European Congress of Radiology（ECR)
  • Place of Presentation: Vienna, Austria
• [Presentation] Surgically Implanted Flexible Spacer in Particle Therapy: Making Temporal Space between Tumor and Adjacent Organs! (2012)
  • Author(s): Sasaki R
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Radiotherapy for Squamous Cell Carcinomas of Oropharynx (2012)
  • Author(s): Miyawaki D
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Postoperative radiotherapy for the malignant tumors of the parotid gland (2012)
  • Author(s): Muraoka O
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Therapeutic Strategies aimed at Laryngeal Preservation of T1-T3N0 Glottic Laryngeal cancer (2012)
  • Author(s): Harada A
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Clinical results of Particle beam radiation therapy for Lung metastases (2012)
  • Author(s): Shazurina Nor
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Evaluation of Newly Developed Nanoparticles on Radiosensitization Effect in Pancreas Cancer Tumor Models (2012)
  • Author(s): Nakayama M
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] A Novel Radiosensitizor, Monogalactosyldiacyglycerol (MDGD) from Spinach, Enhanced the Cytotoxicity of Radiotherapy to Pancreatic Cancer (2012)
  • Author(s): Akasaka H
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Normal tissue tolerance microbeam X-ray irradiation (2012)
  • Author(s): Mukumoto N
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Chemoradiotherapy in Patients with Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (2012)
  • Author(s): Nishimura H
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Radiation therapy for brainstem gliomas in children and adults (2012)
  • Author(s): Yoshida K
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Impact of MGDG Promoter Methylation Status and MIB-1 Labeling Index on Recurrence Pattern after Multimodal Treatment in Glioblastoma (2012)
  • Author(s): Uehara K
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Stereotactic Body Radiation Therapy for Lung Cancer in Octogenarians (2012)
  • Author(s): Ishihara T
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Hypofractionated stereotactic radiotherapy for brain metastases:Exploration of adhibition and key factors involved in local control rate (2012)
  • Author(s): Ishihara T
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Boston, USA
• [Presentation] Efficacy of Surgically Implanted Flexible Spacer in Particle Therapy: A novel strategy Making Temporal Space between Tumor and Adjacent Organs (2012)
  • Author(s): Akasaka H
  • Organizer: 54th ASTRO Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] Stereotactic Body Radiation Therapy in 95 Patients With Lung Tumors Composed of Ground-glass Opacity (GGO): Results of a Retrospective Multicenter Study (2012)
  • Author(s): Onishi H
  • Organizer: 54th ASTRO Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] Patterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary Approach (2012)
  • Author(s): Nishimura H
  • Organizer: 54th ASTRO Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] Novel Radiosensitization Through Reactive Oxygen Species Generation Using Titanium Peroxide Nanoparticle Compounds Against Pancreas Cancer (2012)
  • Author(s): Nakayama M
  • Organizer: 54th ASTRO Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] Involved-Field Radiation Therapy Using Protons or Carbon Ions for N1-2M0 Non-small Cell Lung Cancer: A Retrospective Study (2012)
  • Author(s): Fujii O
  • Organizer: 54th ASTRO Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] Hypofractionated Stereotactic Radiation Therapy for Brain Metastases: Exploration of Adhibition and Key Factors Involved in Local Control Rate (2012)
  • Author(s): Ishihara T
  • Organizer: 54th ASTRO Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] Combination Efficacy of MGMT Promoter Methylation Status and MIB-1 Labeling Index for Pattern of Recurrence in Glioblastoma (2012)
  • Author(s): Uehara K
  • Organizer: 98th Scientific Assembly and Annual Meeting of The Radiological Society of North America
  • Place of Presentation: Chicago, USA
• [Presentation] Radiation therapy for brainstem gliomas in children and adults (2012)
  • Author(s): Yoshida K
  • Organizer: The 14th Asian Oceanian Congress of Radiology
  • Place of Presentation: Sydney, Australia
• [Presentation] Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck (2011)
  • Author(s): Y. Demizu, K. Terashima, M. Mima, O. Fujii, Y. Niwa, K. Morimoto, R. Sasaki, Y. Hishikawa, M. Abe, M. Murakami.
  • Organizer: 53rd ASTRO
  • Place of Presentation: Miami, Florida, USA
• [Presentation] Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling Index (2011)
  • Author(s): K. Uehara, R. Sasaki, D. Miyawaki, H. Nishimura, K. Yoshida, M. Nakayama, T. Soejima, O. Fujii, T. Sasayama, K. Sugimura
  • Organizer: 53rd ASTRO
  • Place of Presentation: Miami, Florida, USA
• [Presentation] Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study (2011)
  • Author(s): D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, S. Hasegawa, K. Nibu, K. Sugimura, R. Sasaki.
  • Organizer: 53rd ASTRO
  • Place of Presentation: Miami, Florida, USA
• [Presentation] Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy (2011)
  • Author(s): N. Hashimoto, R. Sasaki, H. Nishimura, K. Yoshida, D. Miyawaki, Y. Okamoto, Y. Ejima, A. Azumi, T. Matsui, K. Sugimura
  • Organizer: 53rd ASTRO
  • Place of Presentation: Miami, Florida, USA
• [Presentation] Microplanar Beams Radiation: Is Brain Really A Serial Organ (2011)
  • Author(s): N. Mukumoto, R. Sasaki, H. Akasaka, M. Nakayama, D. Miyawaki, H. Nishimura, K. Umetani, T. Kondoh, K. Shinohara, K. Sugimura
  • Organizer: 53rd ASTRO
  • Place of Presentation: Miami, Florida, USA
• [Presentation] Radiation Therapy For Brain Stem Gliomas In Children And Adults (2011)
  • Author(s): K. Yoshida, H. Nishimura, D. Miyawaki, O. Muraoka, K. Uehara, M. Nakayama, R. Sasaki, K. Sugimura.
  • Organizer: 53rd ASTRO
  • Place of Presentation: Miami, Florida, USA
• [Presentation] Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective Study (2011)
  • Author(s): D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, K. Sugimura, S. Hasegawa, K. Nibu, R. Sasaki
  • Organizer: 16th ECCO.
  • Place of Presentation: Stockholm , Sweden
• [Presentation] Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus-a Retrospective Study (2011)
  • Author(s): D Miyawaki
  • Organizer: European Cancer Conference (ECCO) 16th Annual Meeting
  • Place of Presentation: ストックホルム
• [Presentation] Radiotherapy for Elderly Patients with Cervical Cancer (2011)
  • Author(s): K Yoshida
  • Organizer: European Cancer Conference (ECCO) 16th Annual Meeting
  • Place of Presentation: ストックホルム
• [Presentation] Treatment Outcomes of Particle Radiotherapy Using Protons or Carbon Ions as a Single-Modality Therapy for Adenoid Cystic Carcinoma of the Head and Neck (2011)
  • Author(s): Y Demizu
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment : Relationship to MIB-1 Labeling Index (2011)
  • Author(s): K Uehara
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Bone Injury after Definitive Radiotherapy for Uterine Cervical Cancer : Retrospective Analysis of Risk Factors (2011)
  • Author(s): H Uezono
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus : A Retrospective Study (2011)
  • Author(s): D Miyawaki
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Proton Beam Therapy and Carbon-ion Radiotherapy for T2a-T2bN0M0 Non-small Cell Lung Cancer (2011)
  • Author(s): H Iwata
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Long-term Outcome and Patterns of Failure inPrimary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy (2011)
  • Author(s): N Hashimoto
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Microplanar Beams Radiation : Is Brain Really A Serial Organ? (2011)
  • Author(s): N Mukumoto
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Radiation Therapy For Brain Stem Gliomas In Children And Adults (2011)
  • Author(s): K Yoshida
  • Organizer: American Society of Therapeutic Radiation Oncology (ASTRO) 53rd Annual Meeting
  • Place of Presentation: マイアミビーチ
• [Presentation] Nuclear factor-kappa B Expression as A Novel Marker of Radioresistance in Early-Stage Laryngeal Cancer (2011)
  • Author(s): R Sasaki
  • Organizer: 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
  • Place of Presentation: 神戸
• [Presentation] がん放射線療法の基礎知識 (2010)
  • Author(s): 佐々木良平
  • Organizer: 2010年度全国看護セミナー
  • Place of Presentation: 京都府看護協会研修センター(京都府)
  • Year and Date: 2010-09-25
• [Presentation] 放射線治療に関するトランスレーショナルリサーチ (2010)
  • Author(s): 佐々木良平
  • Organizer: 第4回慶應義塾大学放射線治療再教育コース「高精度放射線治療の基礎知識再構築」
  • Place of Presentation: 慶應義塾大学(東京都)
  • Year and Date: 2010-09-11
• [Presentation] Particle-BeamRadiation Therapy for Skull Base Chordomas:A Retrospective Study. (2010)
  • Author(s): D.Miyawaki, Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Yoshida, H.Nishimura, R. Sasaki, M.Murakami
  • Organizer: 52nd ASTRO.
  • Place of Presentation: SanDiego, CA, USA
• [Presentation] Particle-BeamRadiation Therapy for Skull Base Chordomas:A Retrospective Study (2010)
  • Author(s): D.Miyawaki, Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Yoshida, H.Nishimura, R.Sasaki, M.Murakami
  • Organizer: 52nd ASTRO.
  • Place of Presentation: SanDiego, CA, USA
• [Presentation] Particle Radiotherapy using Protons or Carbon Ions for Adenoid Cystic Carcinoma of the Head and Neck (2010)
  • Author(s): Y.Demizu, K.Terashima, M.Mima, O.Fujii, Y.Niwa, K.Morimoto, Y.Hishikawa, M.Abe, M.Murakami.
  • Organizer: 52nd ASTRO
  • Place of Presentation: SanDiego, CA, USA
• [Presentation] Particle-BeamRadiation Therapy for Skull Base Chordomas : A Retrospective Study (2010)
  • Author(s): D.Miyawaki
  • Organizer: 52nd ASTRO
  • Place of Presentation: San Diego, USA
• [Presentation] Particle Radiotherapy using Protons or Carbon Ions for Adenoid Cystic Carcinoma of the Head and Neck (2010)
  • Author(s): Y.Demizu
  • Organizer: 52nd ASTRO
  • Place of Presentation: San Diego, USA
• [Presentation] Radiotherapy for Elderly Patients with Cervical Cancer (2010)
  • Author(s): K.Yoshida
  • Organizer: 52nd ASTRO
  • Place of Presentation: San Diego, USA
• [Presentation] 頭蓋底脊索腫に対する粒子線治療 (2010)
  • Author(s): 宮脇大輔
  • Organizer: 第69回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 放射線治療が施行された喉頭原発悪性リンパ腫の3例 (2010)
  • Author(s): 上薗玄
  • Organizer: 第69回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 当院における中枢神経原発悪性リンパ腫に対する放射線治療の遡及的検討 (2010)
  • Author(s): 石原武明
  • Organizer: 第69回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 頭蓋内germ cell tumorに対する放射線治療成績 (2010)
  • Author(s): 河辺哲也
  • Organizer: 第69回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 高齢子宮頚癌患者に対する放射線治療の経験 (2010)
  • Author(s): 吉田賢史
  • Organizer: 第69回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 局所進行下咽頭癌に対する術後照射の遡及的検討 (2010)
  • Author(s): 西村英輝
  • Organizer: 第69回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 教育講演-喉頭癌 (2010)
  • Author(s): 佐々木良平
  • Organizer: 第69回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 頭頚部原発・髄外性形質細胞腫に対する放射線治療成績の多施設調査研究 (2010)
  • Author(s): 佐々木良平
  • Organizer: 第34回頭頚部癌学会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] Vitamin K新規誘導体を用いた放射線抵抗性の克服に関する基礎研究 (2010)
  • Author(s): 佐々木良平
  • Organizer: 第40回放射線による制癌シンポジウム
  • Place of Presentation: ホテルさっぽろ芸文館(北海道)
• [Presentation] 眼付属器MALTリンパ腫の放射線治療成績の検討 (2010)
  • Author(s): 橋本直樹
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート(東京都)
• [Presentation] 当院における食道癌に対する化学放射線治療の遡及的検討 (2010)
  • Author(s): 関井修平
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート(東京都)
• [Presentation] 当院で放射線治療を施行した悪性神経膠腫の再発形式に関する検討 (2010)
  • Author(s): 宮脇大輔
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 東京ベイ舞浜ホテルクラプリゾート(東京都)
• [Presentation] 局所進行外自動扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験 (2010)
  • Author(s): 吉田賢史
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート(東京都)
• [Book] 最新放射線医学（放射線医学総論) 第8巻2章 放射線治療計画 (2012)
  • Author(s): 西村英輝
  • Publisher: 金芳堂
• [Book] 最新放射線医学（放射線医学総論) 第8巻7章 放射線治療における医療事故防止 (2012)
  • Author(s): 吉田賢史
  • Publisher: 金芳堂
• [Book] 最新放射線医学（放射線医学総論) 第8巻19章 皮膚・軟部・骨疾患の放射線治療 (2012)
  • Author(s): 佐々木良平
  • Publisher: 金芳堂
• [Book] カラーアトラス 目で見て学ぶ放射線療法の有害反応 (2011)
  • Author(s): 丹生健一、佐々木良平(編集)
  • Publisher: 日本看護協会出版会
• [Book] カラーアトラス 目で見て学ぶ放射線療法の有害反応:第1 章 がん放射線療法の現況 (2011)
  • Author(s): 丹生健一、佐々木良平(分担執筆)
  • Publisher: 日本看護協会出版会
• [Book] カラーアトラス 目で見て学ぶ放射線療法の有害反応:第2 章 放射線療法の有害反応 (2011)
  • Author(s): 佐々木良平(分担執筆)
  • Publisher: 日本看護協会出版会
• [Book] 最新放射線医学(放射線医学総論) 第1巻 14 章 放射線物理学 (2011)
  • Author(s): 中山雅央、佐々木良平(編者:富山憲幸、中川恵一)
  • Publisher: 金芳堂
• [Book] Cervical Cancer: Cervical cancer treatment in aging women (2011)
  • Author(s): K Yoshida, R Sasaki, H Nishimura, D Miyawaki, K Sugimura(Editor,R Rajamanicham)
  • Publisher: INTECH
• [Book] 最新放射線医学(放射線医学総論) 第8巻 2 章 放射線治療計画 (2011)
  • Author(s): 西村英輝、佐々木良平 (編者:猪俣泰典)
  • Publisher: 金芳堂
• [Book] 最新放射線医学(放射線医学総論) 第8巻 7 章 放射線治療における医療事故防止 (2011)
  • Author(s): 吉田賢史、佐々木良平(編者:猪俣泰典)
  • Publisher: 金芳堂
• [Book] 最新放射線医学(放射線医学総論) 第8巻 19 章 皮膚・軟部・骨疾患の放射線治療 (2011)
  • Author(s): 佐々木良平、尾藤利憲(編者:猪俣泰典)
• [Book] 耳鼻咽喉科・頭頚部外科研修ノート:放射線療法 (2011)
  • Author(s): 佐々木良平(分担)
  • Publisher: 診断と治療社
• [Book] カラーアトラス目で見て学ぶ放射線療法の有害反応 (2011)
  • Author(s): 佐々木良平(共著)
  • Publisher: 日本看護協会出版会
• [Book] カラーアトラス目で見て学ぶ放射線療法の有害反応:第1章がん放射線療法の現況 (2011)
  • Author(s): 佐々木良平(分担)
  • Publisher: 日本看護協会出版会
• [Book] 耳鼻咽喉科・頭頚部外科研修ノート (2011)
  • Author(s): 佐々木良平
  • Publisher: 診断と治療社
• [Book] カラーアトラス目で見て学ぶ放射線療法の有害反応 (2011)
  • Author(s): 佐々木良平
  • Publisher: 日本看護協会出版会
• [Book] がん・放射線療法2010:下垂体腺腫 (2010)
  • Author(s): 佐々木良平(分担執筆)、宮脇大輔(編者:大西洋、唐澤久美子、唐澤克之)
• [Book] がん・放射線療法 2010 別冊:下垂体腺腫 (2010)
  • Author(s): 佐々木良平(分担執筆)、宮脇大輔(編者:大西洋、唐澤久美子、唐澤克之)
• [Book] 耳鼻咽喉科・頭頚部外科研修ノート:放射線療法 (2010)
  • Author(s): 佐々木良平(分担執筆)(編者:丹生健一、森山寛)
  • Publisher: 診断と治療社
• [Book] がん・放射線療法2010 (2010)
  • Author(s): 佐々木良平・宮脇大輔
  • Publisher: 篠原出版社
• [Book] がん・放射線療法2010別冊 (2010)
  • Author(s): 佐々木良平、宮脇大輔
  • Publisher: 篠原出版社