Development of Functional Image-Guided Radiotherapy Planning inIntensity-Modulated Radiation Therapy (IMRT) for Lung Cancer

• Project/Area Number: 22591385
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hiroshima University
• Principal Investigator: KIMURA Tomoki 広島大学, 病院, 講師 (90379876)
• Co-Investigator(Kenkyū-buntansha): NAGATA Yasushi 広島大学, 医歯薬保健学研究院, 教授 (10228033) ; MURAKAMI Yuji 広島大学, 医歯薬保健学研究院, 講師 (10403528)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線腫瘍学 / 肺機能画像 / 4次元CT / 高精度放射線治療計画

Research Abstract

We performed a simulation study in eight lung cancer patients, and concluded functional image-guided radiotherapy planning based on low attenuation area (LAA) in IMRT or IMAT appeared to be effective in preserving a functional lung in lung cancer patients with chronic obstructive pulmonary disease (COPD). After that, Hiroshima University Hospital Review Board approved this study, and we collected data of 4D-CT, pulmonary perfusion image, pulmonary function of lung cancer patients who received radiotherapy to determine optimal functional imaging.

Research Products

• [Journal Article] Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma (2013)
  • Author(s): Yohji Honda, Tomoki Kimura, Hiroshi Aikata, Tomoki Kobayashi, Takayuki Fukuhara, Keiichi Masaki, Takashi Nakahara, Noriaki Naeshiro, Atsushi Ono, Daisuke Miyaki, Yuko Nagaoki, Tomokazu Kawaoka, Shintaro Takaki, Akira Hiramatsu, Masaki Ishikawa,Hideaki Kakizawa, Masahiro kenjo,Shoichi Takahashi, Kazuo Awai, Yasushi Nagata and Kazuaki Chayama
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 28 Pages: 530-536
  • Peer Reviewed
• [Journal Article] Multi-institutional comparison of treatment planning using stereotactic ablative body radiotherapy for hepatocellular carcinoma -- benchmark for a prospective multi-institutional study (2013)
  • Author(s): Takahisa Eriguchi, Atsuya Takeda, Yohei Oku, Satoshi Ishikura, Tomoki Kimura, Shuichi Ozawa, Takeo Nakashima, Yukinori Matsuo, Mitsuhiro Nakamura, Yasuo Matsumoto, Sadanori Yamazaki, Naoko Sanuki, Yoshinori Ito
  • Journal Title: Radiation Oncology 2013 Volume: 8 Pages: 113-113
  • Peer Reviewed
• [Journal Article] Dynamic Computed Tomography Appearance of Tumor Response after Stereotactic Body Radiation Therapy for hepatocellular Carcinoma -How should we evaluate treatment effects?- (2013)
  • Author(s): Tomoki Kimura, et al
  • Journal Title: Hepatology Research Volume: In press
  • NAID: 10031194575
• [Journal Article] Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma (2013)
  • Author(s): Yohji Honda, Tomoki Kimura, et al
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: In press
• [Journal Article] Radiation Pneumonitis in Patients with Lung and Mediastinal Tumors: A retrospective study of risk factors focused on pulmonary emphysema. (2012)
  • Author(s): Tomoki Kimura, Taro Togami, Hitoshi Takashima, Yoshihiro Nishiyama, Motoomi Ohkawa, Yasushi Nagata
  • Journal Title: British J. Radiol Volume: 85 Pages: 135-141
  • Peer Reviewed
• [Journal Article] Functional Image-Guided Radiotherapy Planning in Respiratory-Gated Intensity-Modulated Radiation Therapy (IMRT) for Lung Cancer Patients with chronic obstructive pulmonary disease (COPD). (2012)
  • Author(s): Tomoki Kimura, Ikuno Nishibuchi, Yuji Murakami, Masahiro Kenjo, Yuko Kaneyasu, Yasushi Nagata
  • Journal Title: Int.J. Radiat. Oncol. Biol. Phys Volume: 82
  • NAID: 120006547415
  • Peer Reviewed
• [Journal Article] Long-term outcomes of intraluminal brachytherapy in combination with external beam radiotherapy for superficial esophageal cancer (2012)
  • Author(s): Yuji Murakami, Yasushi Nagata, Ikuno Nishibuchi, Tomoki Kimura, Masahiro Kenjo, Yuko Kaneyasu, Tomoyuki Okabe, Yasutoshi Hashimoto and Yukio Akagi
  • Journal Title: Int.J. Clin. Oncol Volume: 17 Pages: 263-271
  • NAID: 10030951636
  • Peer Reviewed
• [Journal Article] A pilot feasibility study of neoadjuvant chemoradiotherapy with S-1 in patients with locally advanced gastric cancer featuring adjacent tissue invasion or JGCA-bulky-N2 lymph node metastases (2012)
  • Author(s): Tatsushi Inoue, Shinichi Yachida, Hisashi Usuki, Tomoki Kimura, Masanobu Hagiike, Keiichi Okano, and Yasuyuki Suzuki.
  • Journal Title: Annals ofSurgical Oncology Volume: 19 Pages: 2937-2945
  • Peer Reviewed
• [Journal Article] Hepatic arterial infusion chemotherapy using 5-fluorouracil and systemic interferon-αfor advanced hepatocellular carcinoma in combination with or without three-dimensional conformal radiotherapy to venous tumor thrombosis in hepatic vein or inferior vena cava (2012)
  • Author(s): Eisuke Murakami, Hiroshi Aikata, Daisuke Miyaki, Yuko Nagaoki, Yoshio Katamura, Tomokazu Kawaika, Shintaro Takaki, Akira Hiramatsu, Koji Waki, Shoichi Takahashi, Tomoki Kimura, Masahiro Kenjo, Yasushi Nagata, Masaki Ishikawa, Hideaki Kakizawa, Kazuo Awai and Kazuaki Chayama
  • Journal Title: Hepatology Research Volume: 42 Pages: 442-453
  • NAID: 10031144258
  • Peer Reviewed
• [Journal Article] 第51回日本肺癌学会シンポジウム 4 肺癌に対する高精度放射線治療の現状「4 次元照射と呼吸同期照射」 (2012)
  • Author(s): 木村智樹、西渕いくの、村上祐司,権丈雅浩,兼安祐子,永田 靖
  • Journal Title: 肺癌学会誌 Volume: 52(2) Pages: 174-181
  • Peer Reviewed
• [Journal Article] 第51回日本肺癌学会シンポジウム4 肺癌に対する高精度放射線治療の現状「4次元照射と呼吸同期照射」 (2012)
  • Author(s): 木村智樹
  • Journal Title: 肺癌学会誌 Volume: 52 Pages: 174-181
• [Journal Article] Functional Image-Guided Radiotherapy Planning in Respiratory-Gated Intensity-Modulated Radiation Therapy (IMRT) for Lung Cancer patients with chronic obstructive pulmonary disease (COPD) (2012)
  • Author(s): Tomoki Kimura, et al
  • Journal Title: Int.J.of Radiation Oncology Biology・Physics Volume: 82
  • NAID: 120006547415
  • Peer Reviewed
• [Journal Article] Radiation Pneumonitis in Patients with Lung and Mediastinal Tumors : A retrospective study of risk factors focused on pulmonary emphysema (2012)
  • Author(s): Tomoki Kimura, et al
  • Journal Title: The British Journal of Eadiology Volume: 85 Pages: 135-141
  • Peer Reviewed
• [Journal Article] Long-term outcomes of intraluminal brachytherapy in combination with extemal beam radiotherapy for superficial esophageal cancer (2012)
  • Author(s): Yuji Murakami, Yasushi Nagata, Ikuno Nishibuchi, Tomoki Kimura, et al
  • Journal Title: International Journal of Clinical Oncology Volume: (In press)
  • Peer Reviewed
• [Journal Article] COPD を有する肺癌における 肺機能画像を用いた IMRT の試み (2011)
  • Author(s): 木村智樹、西淵いくの、村上祐司、権丈雅浩、 兼安祐子、永田 靖
  • Journal Title: 癌の臨床 Volume: 57(3) Pages: 109-115
  • Peer Reviewed
• [Journal Article] Radiation Pneumonitis in Patients with Lung and Mediastinal Tumors : A retrospective study of risk factors focused on pulmonary emphysema. (2011)
  • Author(s): Tomoki Kimura, et al
  • Journal Title: The British Journal of Radiology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non-Small-Cell Lung Cancer : Can SBRT Be Comparable to Surgery? (2011)
  • Author(s): Hiroshi Onishi, Tomoki Kimura, et al
  • Journal Title: Int.J.of Radiation Oncology Biology・Physics Volume: (In press)
  • Peer Reviewed
• [Journal Article] The impact of Incidental Irradiation on Clinically Uninvolved Nodal Regions in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Involved-Field Radiation Therapy (IF-RT)-Does Incidental Irradiation Contribute to the Low Incidence of Elective Nodal Failure (ENF)?- (2010)
  • Author(s): Tomoki Kimura, et al
  • Journal Title: Int.J.of Radiation Oncology Biology・Physics Volume: 77 Pages: 337-343
  • Peer Reviewed
• [Journal Article] Dynamic Computed Tomography Appearance of Tumor Response after Stereotactic Body Radiation Therapy for hepatocellular Carcinoma -How should we evaluate treatment effects?
  • Author(s): Tomoki Kimura, Shigeo Takahashi,Masahiro Kenjo, Ikuno Nishibuchi,Ippei Takahashi, Yuki Takeuchi, Yoshiko DOI:, Yuko Kaneyasu, Yuji Murakami, Yoji Honda, Hiroshi Aikata, Kazuaki Chayama, Yasushi Nagata
  • Journal Title: Hepatology Research
  • NAID: 10031194575
  • Peer Reviewed
• [Presentation] The treatment results and dosimetric analysis of Stereotactic Body Radiation Therapy (SBRT) with Transarterial Chemoembolization (TACE) for Hepatocellular Carcinoma (HCC) (2012)
  • Author(s): Tomoki Kimura, Shigeo Takahashi, Ikuno Nishibuchi, Ippei Takahashi, Yuki Takeuchi, Yoshiko DOI:, Masahiro Kenjo, Yuko Kaneyasu, Yuji Murakami, Yasushi Nagata
  • Organizer: Proceedings of the 54thannual ASTRO Meeting
  • Place of Presentation: (Boston), USA
• [Presentation] Portal Vein and Bile Duct Toxicity Following Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma (HCC) (2012)
  • Author(s): Shigeo Takahashi, Tomoki Kimura, Ikuno Nishibuchi, Ippei Takahashi, Yuki Takeuchi, Yoshiko DOI:, Masahiro Kenjo, Yuko Kaneyasu, Yuji Murakami, Yasushi Nagata
  • Organizer: Proceedings of the 54thannual ASTRO Meeting
  • Place of Presentation: (Boston), USA
• [Presentation] Treatment Results of Definitive Radiation Therapy for Elderly Patients with Esophageal Squamous Cell Carcinoma (2012)
  • Author(s): Yuji Murakami, Yasushi Nagata, Ippei Takahashi, Yoshiko, Masahiro Kenjo, Yuko Kaneyasu, Tomoki Kimura
  • Organizer: Proceedings of the 54thannual ASTRO Meeting
  • Place of Presentation: (Boston), USA
• [Presentation] The Frequency of Adverse Events by Radiation Therapy for Atomic Bomb Survivors with Cancer (2012)
  • Author(s): Yoshiko DOI:, Masahiro Kenjo, Ippei Takahashi, Yuki Takeuchi, Shigeo Takahashi, Ikuno Nishibuchi, Yuko Kaneyasu, Yuji Murakami, Tomoki Kimura, Yasushi Nagata
  • Organizer: Proceedings of the 54thannual ASTRO Meeting
  • Place of Presentation: (Boston), USA
• [Presentation] Imaging findings of liver parenchyma after stereotactic body radiation therapy for hepatocellular carcinoma: Evaluation by gadoxetate disodium-enhanced hepatic MRI (2012)
  • Author(s): Nakamura Y, Kimura T, Higaki T, Kaichi Y, Tatsugami F, Date S, Awai K
  • Organizer: 98thScientific Assembly and Annual Meeting RSNA 2012
  • Place of Presentation: (Chicago). USA
• [Presentation] The treatment results and dosimetric analysis of Stereotactic Body Radiation Therapy (SBRT) with Transarterial Chemoembolization (TACE) for Hepatocellular Carcinoma (HCC). (2012)
  • Author(s): Tomoki Kimura, et al
  • Organizer: The 54th American Society for Radiation Oncology Annual meeting
  • Place of Presentation: Boston, MA, USA
• [Presentation] Portal Vein and Bile Duct Toxicity Following Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma (HCC). (2012)
  • Author(s): Shigeo Takahashi, Tomoki Kimura, et al.
  • Organizer: The 54th American Society for Radiation Oncology Annual meeting
  • Place of Presentation: Boston, MA, USA
• [Presentation] Treatment Results of Definitive Radiation Therapy for Elderly Patients with Esophageal Squamous Cell Carcinoma. (2012)
  • Author(s): Yuji Murakami, Yasushi Nagata, Tomoki Kimura,et al.
  • Organizer: The 54th American Society for Radiation Oncology Annual meeting
  • Place of Presentation: Boston, MA, USA
• [Presentation] The Frequency of Adverse Events by Radiation Therapy for Atomic Bomb Survivors with Cancer. (2012)
  • Author(s): Yoshiko Doi, Masahiro Kenjo, Ippei Takahashi, Yuki Takeuchi, Shigeo Takahashi, Ikuno Nishibuchi, Yuko Kaneyasu,Yuji Murakami, Tomoki Kimura, Yasushi Nagata.
  • Organizer: The 54th American Society for Radiation Oncology Annual meeting
  • Place of Presentation: Boston, MA, USA
• [Presentation] 肺癌放射線治療の現状と課題 (2011)
  • Author(s): 木村智樹
  • Organizer: 広島赤十字原爆病院オープンカンファレンス
  • Place of Presentation: 広島市(招待講演)
  • Year and Date: 2011-10-20
• [Presentation] Dynamic CT Appearance of Tumor Response and Radiation Injury of the Liver after Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular carcinoma (HCC) (2011)
  • Author(s): Tomoki Kimura, et al
  • Organizer: The 53^<rd> American Society for Radiation Oncology Annual meeting
  • Place of Presentation: Miami, FL, USA
  • Year and Date: 2011-10-01
• [Presentation] Treatment Results of Chemoradiotherapy with a Dose of >=60 Gy and an Elective Nodal Irradiation for Stage I Esophageal Squamous Cell Carcinoma (2011)
  • Author(s): Yuji Murakami, Tomoki Kimura, et al
  • Organizer: The 53^<rd> American Society for Radiation Oncology Annual meeting
  • Place of Presentation: Miami, FL, USA
  • Year and Date: 2011-10-01
• [Presentation] The Dynamics of Histone Variant H2A.Z upon DNA Damage (2011)
  • Author(s): Ikuno Nishibuchi, Tomoki Kimura, et al
  • Organizer: The 53^<rd> American Society for Radiation Oncology Annual meeting
  • Place of Presentation: Miami, FL, USA
  • Year and Date: 2011-10-01
• [Presentation] 非小細胞肺癌における放射線治療の現状と課題 (2011)
  • Author(s): 木村智樹
  • Organizer: 第7回鳥取胸部疾患研究会
  • Place of Presentation: 米子市(招待講演)
  • Year and Date: 2011-06-09
• [Presentation] 局所進行肺癌に対するInvolved-field radiation therapyの現状と展望 (2011)
  • Author(s): 木村智樹
  • Organizer: 群馬大学がんプロ放射線腫瘍専門医コース・重粒子線治療推進研修コース合同講演会
  • Place of Presentation: 前橋市(招待講演)
  • Year and Date: 2011-05-27
• [Presentation] Outcomes of chemoradiotherapy with a high irradiation dose using a 3D radiation treatment planning system for esophageal cancer (2011)
  • Author(s): Yuji Murakami, Yasushi Nagata, Ikuno Nishibuchi, Tomoki Kimura, Masahiro Kenjo, Yuko Kaneyasu
  • Organizer: 2011 ASCO Gastrointestinal cancers Symposium
  • Place of Presentation: (San Francisco). USA
• [Presentation] Dynamic CT Appearance of Tumor Response and Radiation Injury of the Liver after Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular carcinoma (HCC) (2011)
  • Author(s): Tomoki Kimura, Ikuno Nishibuchi, Yuji Murakami, Masahiro Kenjo, Yuko Kaneyasu, Yasushi Nagata
  • Organizer: Proceedings of the 53thannual ASTRO Meeting
  • Place of Presentation: (Miami), USA
• [Presentation] Treatment Results of Chemoradiotherapy with a Dose of > =60 Gy and an Elective Nodal Irradiation for Stage I Esophageal Squamous Cell Carcinoma (2011)
  • Author(s): Yuji Murakami, Ikuno Nishibuchi, Tomoki Kimura, Masahiro Kenjo, Yuko Kaneyasu, Yasushi Nagata
  • Organizer: Proceedings of the 53thannual ASTRO Meeting
  • Place of Presentation: (Miami), USA
• [Presentation] The Dynamics of Histone Variant H2A.Z upon DNA Damage (2011)
  • Author(s): Ikuno Nishibuchi, Tashiro S, Shima H, Tomoki Kimura, Yuji Murakami, Masahiro Kenjo, Yuko Kaneyasu, Yasushi Nagata
  • Organizer: Proceedings of the 53thannual ASTRO Meeting
  • Place of Presentation: (Miami), USA
• [Presentation] 肺癌放射線治療計画における4D-CTを用いた適応放射線治療の有用性 (2010)
  • Author(s): 木村智樹, ら
  • Organizer: 第23回日本放射線腫瘍総会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-23
• [Presentation] 肺癌に対する高精度放射線治療の現状 4次元照射と呼吸同期照射 (2010)
  • Author(s): 木村智樹
  • Organizer: 第51回日本肺癌学会総会(シンポジウム)
  • Place of Presentation: 広島市
  • Year and Date: 2010-11-04
• [Presentation] Functional Image-guided Radiotherapy Planning in Respiratory-gated Intensity Modulated Radiation Therapy (IMRT) for Lung Cancer Patients with Pulmonary Emphysema. (2010)
  • Author(s): Tomoki Kimura, et al
  • Organizer: The 52^<nd> American Society for Radiation Oncology Annual meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-01
• [Presentation] Time-Adjusted Internal Target Volume (TTV) based on Four-Dimensional Computed Tomography (4D-CT) for Radiotherapy Planning of Lung Cancer. (2010)
  • Author(s): Ikuno Nishibuchi, Tomoki Kimura, et al
  • Organizer: The 52^<nd> American Society for Radiation Oncology Annual meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-01
• [Presentation] Sequential Chemoradiotherapy with 24 Gy of Cranial Irradiation for Intracranial Germinoma diagnosed with MRI. (2010)
  • Author(s): Masahiro Kenjo, Tomoki Kimura, et al
  • Organizer: The 52^<nd> American Society for Radiation Oncology Annual meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-11-01
• [Presentation] 肺癌放射線治療の現状と課題 (2010)
  • Author(s): 木村智樹
  • Organizer: 第7回山陰放射線腫瘍学研究会
  • Place of Presentation: 米子市(招待講演)
  • Year and Date: 2010-07-17
• [Presentation] 4D-CTによる肺機能画像を用いた放射線治療計画の試み (2010)
  • Author(s): 木村智樹, ら
  • Organizer: 第69回日本医学放射線学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-04-11
• [Presentation] Time-Adjusted Internal Target Volume (TTV) based on Four-Dimensional Computed Tomography (4D-CT) for Radiotherapy Planning of Lung Cancer (2010)
  • Author(s): Ikuno Nishibuchi, Tomoki Kimura, Takeo Nakashima, Yusuke Ochi, Yuji Murakami, Masahiro Kenjo, Yuko Kaneyasu, Yasushi Nagata
  • Organizer: Proceedings of the 52thannual ASTRO Meeting
  • Place of Presentation: (San Diego), USA
• [Presentation] Functional Image-guided Radiotherapy Planning in Respiratory-gated Intensity Modulated Radiation Therapy (IMRT) for Lung Cancer Patients with Pulmonary Emphysema (2010)
  • Author(s): Tomoki Kimura, Ikuno Nishibuchi, Yuji Murakami, Masahiro Kenjo, Yuko Kaneyasu, Yasushi Nagata
  • Organizer: Proceedings of the 52thannual ASTRO Meeting
  • Place of Presentation: (San Diego), USA
• [Presentation] Sequential Chemoradiotherapy with 24 Gy of Cranial Irradiation for Intracranial Germinoma diagnosed with MRI (2010)
  • Author(s): Masahiro Kenjo, Kazuhiko Sugiyama, Fumiyuki Yamasaki, Yuji Murakami, Tomoki Kimura, Ikuno Nishibuchi, Yuko Kaneyasu, Kaoru Kurisu, Yasushi Nagata
  • Organizer: Proceedings of the 52thannual ASTRO Meeting
  • Place of Presentation: (San Diego), USA
• [Book] 放射線治療計画ガイドライン2012 「唾液腺腫瘍」 (2013)
  • Author(s): 木村智樹
  • Publisher: メディカル教育研究社
• [Book] 「外耳道癌」臨床放射線腫瘍学 (2012)
  • Author(s): 日本放射線腫瘍学研究機構編
  • Publisher: 南江堂
• [Book] 「唾液腺腫瘍」放射線治療計画ガイドライン 2012 (2012)
  • Author(s): 日本医学放射線学会編
  • Publisher: メディカル教育研究社
• [Book] Natanasabapathi G (2012)
  • Author(s): Tomoki Kimura
  • Publisher: InTech
• [Book] Modern Practices in Radiation Therapy: Chapter 4. Involved-Field Radiation Therapy (IF-RT) for Non-Small Cell Lung Cancer (NSCLC) (2012)
  • Author(s): Tomoki Kimura
  • Publisher: InTech
• [Book] 癌・放射線治療 2010 (2010)
  • Author(s): 木村智樹
  • Publisher: 篠原出版
• [Book] 癌・放射線治療別冊 2010 (2010)
  • Author(s): 木村智樹
  • Publisher: 篠原出版
• [Book] 癌・放射線治療別冊 2010 (2010)
  • Author(s): 永田 靖、木村智樹
  • Publisher: 篠原出版
• [Book] がん・放射線療法2010 (2010)
  • Author(s): 木村智樹
  • Total Pages: 1247
  • Publisher: 篠原出版新社
• [Book] がん・放射線療法2010別冊-代表的照射野とCT上のターゲット- (2010)
  • Author(s): 木村智樹
  • Total Pages: 155
  • Publisher: 篠原出版新社