Study on optimization by using functional images for low-risk and high-precision radiotherapy for lung cancer

• Project/Area Number: 22591387
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: SHIOYAMA Yoshiyuki 九州大学, 医学(系)研究科(研究院), 研究員 (10323304)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Katsumasa 九州大学, 大学病院, 准教授 (20284507) ; ARIMURA Hidetaka 九州大学, 大学院医学研究院, 准教授 (20287353) ; YOSHITAKE Tadamasa 九州大学, 大学院医学研究院, 講師 (40452750) ; HONDA Hiroshi 九州大学, 大学院医学研究院, 教授 (90145433) ; HATAKENAKA Masamitsu 札幌医科大学, 医学部, 教授 (40253413) ; ABE Kouichirou 東京女子医科大学, 医学部, 准教授 (00380387)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 肺癌 / 強度変調放射線治療 / 定位放射線治療 / 機能画像 / 機能温存治療 / 高精度放射線治療 / 低リスク治療 / 治療最適化

Research Abstract

In the high-precision radiotherapy (intensity modulated radiation therapy and stereotactic radiation therapy) for lung cancer patients, we quantitatively compared the dose distribution between the treatment plans optimized by using functional images and the treatment plans optimized by using anatomical images only. The optimization using functional images was considered to be useful in minimizing the decrease of pulmonary function, and this approach was thought to be more beneficial to the high-risk patients in particular. Furthermore, this functional-image-guided optimization was suggested to become more effective by using non-coplanar beams in addition to coplanar beams.

Research Products

• [Journal Article] 肺癌の放射線治療 (2014)
  • Author(s): 塩山善之, 中村和正, 佐々木智成, 大賀才路, 吉武忠正, 浅井佳央里, 寺嶋広太郎, 松本圭司, 松尾芳雄, 藪内英剛, 本田浩
  • Journal Title: 画像診断 Volume: 34(2) Pages: 199-205
• [Journal Article] Clinical results of stereotactic body radiotherapy for Stage I small-cell lung cancer; a single institutional experience (2013)
  • Author(s): Shioyama Y, Nakamura K, Sasaki T, Ohga S, Yoshitake T, Nonoshita T, Asai K, Terashima K, Matsumoto K, Hirata H, Honda H
  • Journal Title: J Radiat Res Volume: 54(1) Pages: 108-112
  • Peer Reviewed
• [Journal Article] Computer-aided beam arrangement based on similar cases in radiation treatment-planning databases for stereotactic lung radiation therapy (2013)
  • Author(s): Magome T, Arimura H, Shioyama Y, Mizoguchi A, Tokunaga C, Nakamura K, Honda H, Ohki M, Toyofuku F, Hirata H
  • Journal Title: J Radiat Res Volume: 54(3) Pages: 569-577
  • Peer Reviewed
• [Journal Article] Association between EGFR-TKI Resistance and Efficacy of Radiotherapy for Brain Metastases from EGFR-mutant Lung Adenocarcinoma (2013)
  • Author(s): Hirata H, Nakamura K, Kunitake N, Shioyama Y, Sasaki T, Ohga S, Nonoshita T, Yoshitake T, Asai K, Inoue K, Nagashima A, Ono M, Honda H
  • Journal Title: Anticancer Res Volume: 33(4) Pages: 1649-1655
  • Peer Reviewed
• [Journal Article] Definitive Fractionated Re-irradiation for Local Recurrence Following Stereotactic Body Radiotherapy for Primary Lung Cancer (2013)
  • Author(s): Yoshitake T, Shioyama Y, Nakamura K, Sasaki T, Ohga S, Shinoto M, Terashima K, Asai K, Matsumoto K, Hirata H, Honda H
  • Journal Title: Anticancer Res Volume: 33(12) Pages: 5649-5653
  • Peer Reviewed
• [Journal Article] Phase II study of concurrent thoracic radiotherapy in combination with weekly paclitaxel plus carboplatin in locally advanced non-small cell lung cancer : LOGIK0401 (2013)
  • Author(s): Takayama K, Inoue K, Tokunaga S, Matsumoto T, Oshima T, Kawasaki M,Imanaga T, Kuba M, Takeshita M, Harada T, Shioyama Y, Nakanishi Y
  • Journal Title: Chemother Pharmacol Volume: 72(6) Pages: 1353-1359
  • Peer Reviewed
• [Journal Article] Association between EGFR-TKI resistance and efficacy of radiotherapy for brain metastases from EGFR-mutant lung adenocarcinoma (2013)
  • Author(s): Hirata H, Nakamura K, Kunitake N, Shioyama Y, et al.
  • Journal Title: Anticancer Res Volume: 33(4) Pages: 1649-1655
  • Peer Reviewed
• [Journal Article] Phase II study of concurrent thoracic radiotherapy in combination with weekly paclitaxel plus carboplatin in locally advanced non-small cell lung cancer: LOGIK0401 (2013)
  • Author(s): Takayama K, Inoue K, Tokunaga S, Matsumoto T, Oshima T, Kawasaki M, Imanaga T, Kuba M, Takeshita M, Harada T, Shioyama Y, Nakanishi Y
  • Journal Title: Chemother Pharmacol Volume: 72(6) Issue: 6 Pages: 1353-1359
  • DOI: 10.1007/s00280-013-2335-2
  • Peer Reviewed
• [Journal Article] Radiation-Induced Rib Fractures After Hypofrationated Stereotactic Body Radiation Therapy : Risk Factors and Dose-Volume Relationship (2012)
  • Author(s): Asai K, Shioyama Y, Nakamura K, Sasaki T, Ohga S, Nonoshita T, Yoshitake T, Ohnishi K, Terashima K, Matsumoto K, Hirata H, Honda H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(3) Pages: 768-773
  • Peer Reviewed
• [Journal Article] Stereotactic Body Radiation Therapy for Stage I Non-small Cell Lung Cancer Patients with Chronic Respiratory Insufficiency Requiring Domiciliary Oxygen Therapy (2012)
  • Author(s): Yoshitake T, Nakamura K, Shioyama Y, Sasaki T, Ohga S, Nonoshita T, Terashima K, Asai K, Matsumoto K, Honda H
  • Journal Title: Anticancer Res Volume: 32(9) Pages: 4041-4044
  • Peer Reviewed
• [Journal Article] 重粒子線がん治療の現状と今後の展開 (2012)
  • Author(s): 塩山善之、篠藤誠、松延亮、松本圭司、吉武忠正、鎌田正、辻井博彦、本田浩
  • Journal Title: 福岡医学雑誌 Volume: 103(4) Pages: 73-81
  • NAID: 40019397749
• [Journal Article] Acute cardiac impairment associated with concurrent chemoradiotherapy for esophageal cancer : Magnetic resonance evaluation (2012)
  • Author(s): Hatakenaka M, Yonezawa M, Nonoshita T, Nakamura K, Yabuuchi H, Shioyama Y, Nagao M, Matsuo Y, Kamitani T, Higo T, Nishikawa K, Setoguchi T, Honda H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 83(1)
  • Peer Reviewed
• [Journal Article] Radiation-Induced Rib Fractures After Hypofractionated Stereotactic Body Radiation Therapy: Risk Factors and DoseeVolume Relationship (2012)
  • Author(s): Asai K, Shioyama Y, Nakamura K, et al.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(3) Issue: 3 Pages: 768-773
  • DOI: 10.1016/j.ijrobp.2012.01.027
  • Peer Reviewed
• [Journal Article] Acute cardiac impairment associated with concurrent chemoradiotherapy for esophageal cancer: Magnetic resonance evaluation (2012)
  • Author(s): Hatakenaka M, Yonezawa M, Nonoshita T, Nakamura K, Yabuuchi H, Shioyama Y, et al.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 83(1) Issue: 1 Pages: e67-e73
  • DOI: 10.1016/j.ijrobp.2011.12.018
  • Peer Reviewed
• [Journal Article] A Case of Lung Cancer with Chest Wall Invasion Showed a Pathologically Complete response to PreoperativeThermo-chemo-radiothera py (2011)
  • Author(s): Terashima K, Shioyama Y, Nomoto S, Ohga S, Nonoshita T, Yoshitake T, Ohnishi K, Asai K, Matsumoto K, Takayama K, Nakamura K, Terashima H, Honda H
  • Journal Title: Thermal Medicine Volume: 27 Pages: 25-30
  • Peer Reviewed
• [Journal Article] Clinical Results of Definitive Chemoradiotherapy for Patients With Synchronous Head and Neck Squamous Cell Carcinoma and Esophageal Cancer (2011)
  • Author(s): Shinoto M, Shioyama Y, Sasaki T, Nakamura K, Ohura H, Toh Y, Higaki Y, Yamaguchi T, Ohnishi K, Atsumi K, Hirata H, Honda H
  • Journal Title: Am J Clin Oncol Volume: 34 Pages: 362-366
  • Peer Reviewed
• [Journal Article] Prediction of Local Failures with a Combination of Pretreatment Tumor Volume and Apparent Diffusion Coefficient in Patients Treated with Definitive Radiotherapy for Hypopharyngeal or Oropharyngeal Squamous Cell Carcinoma (2011)
  • Author(s): Ohnishi K, Shioyama Y, Hatakenaka M, Nakamura K, Abe K, Yoshiura T, Ohga S, Nonoshita T, Yoshitake T, Nakashima T, Honda H
  • Journal Title: J Radiat Res Volume: 52 Pages: 522-530
  • NAID: 10029122408
  • Peer Reviewed
• [Journal Article] Apparent Diffusion Coefficient Calculated with Relatively High b-Values Correlates with Local Failure of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy (2011)
  • Author(s): Hatakenaka M, Shioyama Y, Nakamura K, Yabuuchi H, Matsuo Y, Sunami S, Kamitani T, Yoshiura T, Nakashima T, Nishikawa K, Honda H
  • Journal Title: Am J Neuroradiol Volume: 32(10) Pages: 1904-1910
  • Peer Reviewed
• [Journal Article] Clinical Results of Definitive Chemoradiotherapy for Patients With Synchronous Head and Neck Squamous Cell Carcinoma and Esophageal Cancer (2011)
  • Author(s): Shinoto M, Shioyama Y, Sasaki T, et al
  • Journal Title: Am J Clin Oncol Volume: 34(4) Issue: 4 Pages: 362-366
  • DOI: 10.1097/coc.0b013e3181e84b4b
  • Peer Reviewed
• [Journal Article] Prediction of Local Failures with a Combination of Pretreatment Tumor Volume and Apparent Diffusion Coefficient in Patients Treated with Definitive Radiotherapy for Hypopharyngeal or Oropharyngeal Squamous Cell Carcinoma (2011)
  • Author(s): Ohnishi K, Shioyama Y, Hatakenaka M, et al
  • Journal Title: Journal of Radiation Research Volume: 52 Issue: 4 Pages: 522-530
  • DOI: 10.1269/jrr.10178
  • NAID: 10029122408
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] A case of lung cancer with chest wall invasion showed a pathologically complete response to preoperative thermo-chemo-radiotherapy (2011)
  • Author(s): Terashima K, Shioyama Y, Nomoto S, et al.
  • Journal Title: Thermal Medicine Volume: 27(1) Pages: 25-30
  • NAID: 10028165565
  • Peer Reviewed
• [Journal Article] A case of radiation fibrosis appearing as mass-like consolidation after SBRT with elevation of serum CEA (2010)
  • Author(s): Terashima K, Shioyama Y, Nomoto S, Ohga S, Nonoshita T, Ohnishi K, Atsumi K, Yabuuchi H, Hirata H, Honda H
  • Journal Title: Case Report in Medicine Pages: 986706-986706
  • Peer Reviewed
• [Journal Article] A Case of Radiation Fibrosis Appearing as Mass-Like Consolidation after SBRT with Elevation of Serum CEA (2010)
  • Author(s): Terashima K, Shioyama Y, Nomoto S, et al.
  • Journal Title: Case Report Med. Pages: 986706-986706
  • Peer Reviewed
• [Presentation] I期非小細胞肺癌に対する重粒子線治療 (2013)
  • Author(s): 塩山善之
  • Organizer: 第53回日本肺癌学会九州支部学術集会共催シンポジウム
  • Place of Presentation: 那覇市
  • Invited
• [Presentation] Stereotactic Body Radiotherapy for Stage-I Small-cell Lung Cancer : Clinical outcomes in a Japanese Multi-institutional Retrospective Study (2013)
  • Author(s): Shioyama Y, Onishi H, Takayama K, et al
  • Organizer: The 55th. Annual Meeting of American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Atlanta, USA
• [Presentation] Spontaneous pneumothorax after stereotactic body radiotherapy for lung tumor (2013)
  • Author(s): Asai K, Shioyama Y, Nakamura K, et al
  • Organizer: The 55th. Annual Meeting of American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Atlanta, USA
• [Presentation] Japanese multi-institutional study of stereotactic body radiotherapy for more than 2000 patients withstage I non-small cell lung cancer (2013)
  • Author(s): Onishi H, Shioyama Y, Matsumoto Y, et al
  • Organizer: The 55th. Annual Meeting of American Society for Therapeutic Radiology and Oncology (ASTRO)
  • Place of Presentation: Atlanta, USA
• [Presentation] 早期肺癌に対する定位照射 (2013)
  • Author(s): 塩山善之
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 早期肺癌に対する体幹部定位放射線治療 (2013)
  • Author(s): 塩山善之
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: 東京都
  • Invited
• [Presentation] Stereotactic Body Radiotherapy for Stage I Small-cell Lung Cancer: Clinical outcomes in a Japanese Multi-institutional Retrospective Study (2013)
  • Author(s): Shioyama Y, Onishi H, Takayama K, et al.
  • Organizer: The 55th. Annual Meeting of American Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Atlanta, USA
• [Presentation] Spontaneous pneumothorax after stereotactic body radiotherapy for lung tumor (2013)
  • Author(s): Asai K, Shioyama Y, Nakamura K, et al.
  • Organizer: The 55th. Annual Meeting of American Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Atlanta, USA
• [Presentation] Japanese multi-institutional study of stereotactic body radiotherapy for more than 2000 patients with stage I non-small cell lung cancer (2013)
  • Author(s): Onishi H, Shioyama Y, Matsumoto Y, et al.
  • Organizer: The 55th. Annual Meeting of American Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Atlanta, USA
• [Presentation] 早期肺癌に対する定位照射 (2013)
  • Author(s): 塩山善之
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜, 日本
  • Invited
• [Presentation] 早期肺癌に対する体幹部定位放射線治療 (2013)
  • Author(s): 塩山善之
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: 東京, 日本
  • Invited
• [Presentation] Ｉ期非小細胞肺癌に対する重粒子線治療 (2013)
  • Author(s): 塩山善之
  • Organizer: 第５３回日本肺癌学会九州支部学術集会共催シンポジウム
  • Place of Presentation: 那覇市
  • Invited
• [Presentation] 肺癌の定位放射線治療 (2012)
  • Author(s): 塩山善之
  • Organizer: 第3回放射線外科学会
  • Place of Presentation: 大阪市
  • Year and Date: 2012-01-14
  • Invited
• [Presentation] 肺癌の定位放射線治療 (2012)
  • Author(s): 塩山善之
  • Organizer: 第3回放射線外科学会
  • Place of Presentation: 大阪市(招待講演)
  • Year and Date: 2012-01-14
• [Presentation] Predictive Role of Mean Electron Density in Gross Tumor Volume for Local Control in Stage I Non-Small-Cell Lung Cancer Treated with Stereotactic Body Radiotherapy (2012)
  • Author(s): Shioyama Y, Magome T, Nakamura K, et al
  • Organizer: The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Usefulness of Electron Density in Gross Tumor Volume as a Prognostic Factor in Stage I Non-Small-Cell Lung Cancer Treated with Stereotactic Body Radiotherapy (2012)
  • Author(s): Shioyama Y, Nakamura K , Yoshitake T, et al
  • Organizer: The 54th. Annual Meeting of American Society for Therapeutic Radiology and Oncology(ASTRO)
  • Place of Presentation: Boston, USA
• [Presentation] I期非小細胞肺癌の定位照射症例における腫瘍内電子密度とその予後因子としての意義 (2012)
  • Author(s): 塩山善之、中村和正、馬込大貴、他
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京都
• [Presentation] Usefulness of Electron Density in Gross Tumor Volume as a Prognostic Factor in Stage I Non-Small-Cell Lung Cancer Treated with Stereotactic Body Radiotherapy (2012)
  • Author(s): Shioyama Y, Nakamura K , Yoshitake T, et al.
  • Organizer: The 54th. Annual Meeting of American Society for Therapeutic Radiology and Oncology
  • Place of Presentation: Boston, USA
• [Presentation] Ｉ期非小細胞肺癌の定位照射症例における腫瘍内電子密度とその予後因子としての意義 (2012)
  • Author(s): 塩山善之、中村和正、馬込大貴、他
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京
• [Presentation] Stereotactic Body Radiotherapy for Histologically Confirmed Stage I Non-small Cell Lung Cancer : Clinical Results and Prognostic Factors (2011)
  • Author(s): Shioyama Y, Matsumoto K, Yoshitake T, et al
  • Organizer: 53nd. Annual Meeting of American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: Miami, USA
• [Presentation] Fractionated Re-irradiation For Local Recurrence Following Stereotactic Body Radiotherapy For Primary And Metastatic Lung Cancers (2011)
  • Author(s): Yoshitake T, Shioyama Y, Nakamura K, et al
  • Organizer: 53nd.Annual Meeting of American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: Miami, USA
• [Presentation] Stereotactic Body Radiotherapy for Histologically Confirmed Stage I Non-small Cell Lung Cancer : Clinical Results and Prognostic Factors (2011)
  • Author(s): Shioyama Y, Matsumoto K, Yoshitake T, et al
  • Organizer: 53nd.Annual Meeting of American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: Miami, USA
• [Presentation] Clinical Results of Stereotactic Body Radiotherapy for Stage I Small Cell Lung Cancer : A SingleInstitutional Experience (2010)
  • Author(s): Shioyama Y, Ohga S, Yoshitake T, et al
  • Organizer: 52nd. Annual Meeting of American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: San Diego, USA
• [Presentation] I期非小細胞肺癌に対する定位照射における予後因子に関する検討 (2010)
  • Author(s): 塩山善之、松本圭司、大賀才路ら
  • Organizer: 日本放射線腫瘍学会学術大会第23回学術大会
  • Place of Presentation: 浦安市
• [Presentation] Clinical Results of Stereotactic Body Radiotherapy for Stage I Small Cell Lung Cancer : A SingleInstitutional Experience (2010)
  • Author(s): Shioyama Y, Ohga S, Yoshitake T, et al.
  • Organizer: 52nd.Annual Meeting of American Society for Radiation Oncology (ASTRO)
  • Place of Presentation: San Diego, USA
• [Presentation] I期非小細胞肺癌に対する定位照射における予後因子に関する検討 (2010)
  • Author(s): 塩山善之、松本圭司、大賀才路, ら
  • Organizer: 日本放射線腫瘍学会学術大会第23回学術大会
  • Place of Presentation: 千葉県浦安市
• [Book] Textbook of Radiosurgery放射線外科治療の進歩第3章各種放射線の特性 (2012)
  • Author(s): 吉武忠正、塩山善之他
  • Publisher: MCメデイカ出版
• [Book] 放射線治療計画ガイドライン2012年版, (日本放射線腫瘍学会編) (2012)
  • Author(s): 塩山善之他
  • Publisher: 金原出版
• [Book] 放射線治療計画ガイドライン2012年版 「頭頚部」：喉頭癌 (2012)
  • Author(s): 塩山善之（分担執筆）
  • Publisher: 金原出版日本放射線腫瘍学会編
• [Book] Textbook of Radiosurgery放射線外科治療の進歩第3章各種放射線の特性 (2012)
  • Author(s): 吉武忠正、塩山善之
  • Publisher: MCメデイカ出版
• [Book] 修ノートシリーズ呼吸器研修ノート第12章放射線治療2-②小細胞肺癌 (2011)
  • Author(s): 塩山善之他
  • Publisher: 診断と治療社
• [Book] 研修ノートシリーズ呼吸器研修ノート第12章放射線治療2-(2)小細胞肺癌 (2011)
  • Author(s): 塩山善之
  • Publisher: 診断と治療社
• [Patent(Industrial Property Rights)] 粒子線ビーム方向決定システム、粒子線ビーム方向決定方法及び粒子線ビーム方向決定用コンピュータプログラム (2013)
  • Inventor(s): 有村秀孝,垣内玄雄,塩山善之他
  • Industrial Property Rights Holder: 有村秀孝,垣内玄雄,塩山善之他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-22
  • Overseas
• [Patent(Industrial Property Rights)] 粒子線ビーム方向決定システム、粒子線ビーム方向決定方法及び粒 子線ビーム方向決定用コンピュータプログラム (2013)
  • Inventor(s): 有村秀孝, 垣内玄雄, 塩山善之 他
  • Industrial Property Rights Holder: 有村秀孝, 垣内玄雄, 塩山善之 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-22
• [Patent(Industrial Property Rights)] 放射線ビームアングル決定システム、放射線ビームアングル決定方法及び放射線ビームアングル決定用コンピュータプログラム (2012)
  • Inventor(s): 有村秀孝,馬込大貴,塩山善之
  • Industrial Property Rights Holder: 有村秀孝,馬込大貴,塩山善之
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-069606
  • Filing Date: 2012-03-26
  • Overseas
• [Patent(Industrial Property Rights)] 放射線ビームアングル決定システム、放射線ビームアングル決定方法及び放射線ビームアングル決定用コンピュータプログラム (2012)
  • Inventor(s): 有村秀孝, 馬込大貴, 塩山善之
  • Industrial Property Rights Holder: 有村秀孝, 馬込大貴, 塩山善之
  • Industrial Property Number: 2012-069606
  • Filing Date: 2012-03-26