Development of adaptive radiotherapy using preliminarily-contouredstrictures and cone-beam CT for daily setup

• Project/Area Number: 22591388
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: MURAKAMI Ryuji 熊本大学, 生命科学研究部, 教授 (90295147)
• Co-Investigator(Renkei-kenkyūsha): HIRAI Toshinori 熊本大学, 生命科学研究部, 准教授 (40274724) ; KATSURAGAWA Shigehiko 熊本大学, 生命科学研究部, 教授 (60021630)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 放射線治療学 / 放射線治療計画 / 画像融合 / コーンビーム CT / 放射線治療 / 画像誘導放射線治療 / 適応放射線治療 / 腫瘍体積 / コーンビームCT / 線量分布 / 放射線腫瘍学 / 治療計画 / 画像誘導

Research Abstract

We designed a preliminary-contouring system for “double reading”in the gross tumor volume (GTV) assessment. Although there was minor system error,considerable interobserver differences for GTV contouring persisted; our system can bea valuable method for the integration of GTV contouring. The differences in prescribeddoses based on cone-beam computed tomography (CBCT) for daily setup were less than 5%. The combination of the preliminary-contouring system and CBCT-derived dose calculationcan provide adaptive radiotherapy matching with anatomical changes at each fraction.

Research Products

• [Journal Article] Hideo Nakamura, Ryuji Murakami,Toshinori Hirai, Mika Kitajima,Yasuyuki Yamashita (2013)
  • Author(s): Hideo Nakamura, Ryuji Murakami,Toshinori Hirai, Mika Kitajima,Yasuyuki Yamashita
  • Journal Title: Acta Radiol Volume: 54(2) Issue: 2 Pages: 214-220
  • DOI: 10.1258/ar.2012.120525
  • Peer Reviewed
• [Journal Article] Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer (2012)
  • Author(s): Keiko Teshima1, Ryuji Murakami, RyojiYoshida, Hideki Nakayama, AkimitsuHiraki, Toshinori Hirai, Yuji Nakaguchi,Naoko Tsujita, Etsushi Tomitaka,Mitsuhiro Furusawa, Yasuyuki Yamashita,Masanori Shinohara
  • Journal Title: Journal of Radiation Research Volume: 53 Issue: 3 Pages: 492-496
  • DOI: 10.1269/jrr.11115
  • NAID: 130001876862
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] FDG-PET/CT-based Gross Tumor Volume Contouring for Radiation Therapy Planning: An Experimental Phantom Study (2012)
  • Author(s): Ryo Toya, Ryuji Murakami, KuniyukiTashiro, Morikatsu Yoshida, FumiSakamoto, Koichi Kawanaka, ShinyaShiraishi, Yuji Nakaguchi, NaokoTsujita, Natsuo Oya, Seiji Tomiguchi,Yasuyuki Yamashita
  • Journal Title: Journal of Radiation Research Volume: 53 Issue: 2 Pages: 338-341
  • DOI: 10.1269/jrr.10183
  • NAID: 130001876819
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Journal Article] Double reading for grosstumor volume assessment in radiotherapyplanning (2012)
  • Author(s): Ryuji Murakami, Toshinori Hirai, RyoToya, Hideo Nakamura, YasuyukiYamashita
  • Journal Title: Journal of Solid Tumors Volume: 2(4) Issue: 4 Pages: 38-43
  • DOI: 10.5430/jst.v2n4p38
  • Peer Reviewed
• [Journal Article] Recurrence patterns of glioblastomatreated with postoperative radiationtherapy: Relationship between extent ofresection and progression-freeinterval (2012)
  • Author(s): Ryuji Murakami, Toshinori Hirai, HideoNakamura, Mitsuhiro Furusawa, YujiNakaguchi, Hiroyuki Uetani, MikaKitajima, Yasuyuki Yamashita
  • Journal Title: Jpn J Radiol Volume: 30(3) Issue: 3 Pages: 193-197
  • DOI: 10.1007/s11604-011-0031-x
  • Peer Reviewed
• [Journal Article] 位置照合用cone-beam CT を応用した適応放射線治療の検討日本放射線技術学会雑誌 (2012)
  • Author(s): 丸山雅人、村上龍次、中口裕二、筧 清孝、竹永枝里子、辻田直子、大村祐貴、高田橋司、横尾崇幸、斉藤哲雄、松山知彦
  • Journal Title: 位置照合用cone-beam CT を応用した適応放射線治療の検討日本放射線技術学会雑誌 Volume: 68(2) Pages: 162-168
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22382623
  • Peer Reviewed
• [Journal Article] 位置照合用cone-beam CTを応用した適応放射線治療の検討 (2012)
  • Author(s): 丸山雅人、村上龍次
  • Journal Title: 日本放射線技術学会雑誌 Volume: 68 Pages: 162-168
  • NAID: 10030139158
  • Peer Reviewed
• [Journal Article] FDG-PET/CT-based Gross Tumor Volume Contouring for Radiation Therapy Planning : An Experimental Phantom Study (2012)
  • Author(s): Ryo Toya, Ryuji Murakami
  • Journal Title: J Radiat Res Volume: (印刷中)
  • NAID: 130001876819
  • Peer Reviewed
• [Journal Article] Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer (2012)
  • Author(s): Keiko Teshima, Ryuji Murakami
  • Journal Title: J Radiat Res Volume: (印刷中)
  • NAID: 130001876862
  • Peer Reviewed
• [Journal Article] 6 軸カウチの線量補正に関する検討 (2011)
  • Author(s): 中口裕二、 村上龍次、 丸山雅人、 筧 清孝、永末 望、 荒木不次男
  • Journal Title: 日本放射線技術学会雑誌 Volume: 67(12) Pages: 1592-1597
  • NAID: 10030042666
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22186205
  • Peer Reviewed
• [Journal Article] 通常照射法におけるセットアップエラーおよび体型変化が線量分布に及ぼす影響についての検討 (2011)
  • Author(s): 辻田直子、 山口沙希、 村上龍次、 服部隆史、丸山雅人、 中口裕二、 筧 清孝、 斉藤哲雄、手島慶子
  • Journal Title: 日本放射線技術学会雑誌 Volume: 67(12) Pages: 1559-1564
  • NAID: 10030042591
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22186201
  • Peer Reviewed
• [Journal Article] Longitudinal Changes over 2 Years inParotid Glands of Patients Treated withPreoperative 30-Gy Irradiation for OralCancer (2011)
  • Author(s): Etsushi Tomitaka, Ryuji Murakami, KeikoTeshima, Tomoko Nomura, Yuji Nakaguchi,Hideki Nakayama, Mika Kitajima,Toshinori Hirai, Yushi Araki, MasanoriShinohara, Yasuyuki Yamashita
  • Journal Title: Jpn J Clin Oncol Volume: 41(4) Issue: 4 Pages: 503-507
  • DOI: 10.1093/jjco/hyq236
  • Peer Reviewed
• [Journal Article] 通常照射法におけるセットアップエラーおよび体型変化が線量分布に及ぼす影響についての検討 (2011)
  • Author(s): 辻田直子、村上龍次
  • Journal Title: 日本放射線技術学会雑誌 Volume: 67 Pages: 1559-1564
  • NAID: 10030042591
  • Peer Reviewed
• [Journal Article] 6軸カウチの線量補正に関する検討 (2011)
  • Author(s): 中口裕二、村上龍次
  • Journal Title: 日本放射線技術学会雑誌 Volume: 67 Pages: 1592-1597
  • NAID: 10030042666
  • Peer Reviewed
• [Journal Article] PhaseII study of preoperative concurrentchemoradiation therapy with S-1 inpatients with T4 oral squamous cellcarcinoma (2010)
  • Author(s): Tomoko Nomura, Ryuji Murakami, Ryo Toya,Keiko Teshima, Aya Nakahara, ToshinoriHirai, Akimitsu Hiraki, Hideki Nakayama,Yoshiyasu Yoshitake, Kazutoshi Ohta,Obayashi Takehisa, Yasuyuki Yamashita,Natsuo Oya, Masanori Shinohara
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 76(5) Issue: 5 Pages: 1347-1352
  • DOI: 10.1016/j.ijrobp.2009.03.055
  • Peer Reviewed
• [Journal Article] 放射線治療計画のための頭部 MR 画像における膠芽腫の半自動描出 (2010)
  • Author(s): 堀 大輔、 桂川茂彦、 村上龍次、平井俊範
  • Journal Title: 日本放射線技術学会雑誌 Volume: 66(4) Pages: 353-362
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20625222
  • Peer Reviewed
• [Journal Article] 放射線治療計画のための頭部MR画像における膠芽腫の半自動描出 (2010)
  • Author(s): 堀大輔, 桂川茂彦, 村上龍次
  • Journal Title: 日本放射線技術学会雑誌 Volume: 66 Pages: 353-362
  • Peer Reviewed
• [Journal Article] Phase II study of preoperative concurrent chemoradiation therapy with S-1 in patients with T4 oral squamous cell carcinoma (2010)
  • Author(s): Tomoko Nomura, Ryuji Murakami
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 76 Pages: 1347-1352
  • Peer Reviewed
• [Presentation] Clinical nodal stagingand clinical target volume forpreoperative concurrentchemoradiotherapy in patients withadvanced oral cancer (2012)
  • Author(s): Ryuji Murakami
  • Organizer: 第54回米国放射線腫瘍学会(ASTRO 2012)
  • Place of Presentation: ボストン(米国)
• [Presentation] Clinical Nodal Staging and Clinical Target Volume for Preoperative Concurrent Chemoradiotherapy in Patients with Advanced Oral Cancer (2012)
  • Author(s): Ryuji Murakami
  • Organizer: 第54回米国放射線腫瘍学会 （ASTRO 54th Annual Meeting）
  • Place of Presentation: ボストン（米国）
• [Presentation] Can MRI-derived factorspredict survival in patients withglioblastoma multiforme? (2011)
  • Author(s): Ryuji Murakami
  • Organizer: 第53回米国放射線腫瘍学会(ASTRO 2011)
  • Place of Presentation: マイアミ(米国)
• [Presentation] Can MRI-derived factors predict survival in patients with glioblastoma multiforme? (2011)
  • Author(s): Ryuji Murakami
  • Organizer: 第53回米国放射線腫瘍学会(ASTRO 2011)
  • Place of Presentation: マイアミ(米国)
• [Presentation] Recurrence patterns ofglioblastomas treated withpostoperative radiation therapy:Relationship between extent ofresection and progression-freeinterval (2010)
  • Author(s): Ryuji Murakami
  • Organizer: 第52回米国放射線腫瘍学会
  • Place of Presentation: サンディエゴ(米国)
• [Presentation] Recurrence patterns of glioblastomas treated with postoperative radiation therapy : Relationship between extent of resection and progression-free interval (2010)
  • Author(s): Ryuji Murakami
  • Organizer: 第52回米国放射線腫瘍学会(ASTRO 2010)
  • Place of Presentation: サンディエゴ(米国)