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Development of adaptive radiotherapy using preliminarily-contouredstrictures and cone-beam CT for daily setup

Research Project

Project/Area Number 22591388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKumamoto University

Principal Investigator

MURAKAMI Ryuji  熊本大学, 生命科学研究部, 教授 (90295147)

Co-Investigator(Renkei-kenkyūsha) HIRAI Toshinori  熊本大学, 生命科学研究部, 准教授 (40274724)
KATSURAGAWA Shigehiko  熊本大学, 生命科学研究部, 教授 (60021630)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords放射線治療学 / 放射線治療計画 / 画像融合 / コーンビーム CT / 放射線治療 / 画像誘導放射線治療 / 適応放射線治療 / 腫瘍体積 / コーンビームCT / 線量分布 / 放射線腫瘍学 / 治療計画 / 画像誘導
Research Abstract

We designed a preliminary-contouring system for “double reading”in the gross tumor volume (GTV) assessment. Although there was minor system error,considerable interobserver differences for GTV contouring persisted; our system can bea valuable method for the integration of GTV contouring. The differences in prescribeddoses based on cone-beam computed tomography (CBCT) for daily setup were less than 5%. The combination of the preliminary-contouring system and CBCT-derived dose calculationcan provide adaptive radiotherapy matching with anatomical changes at each fraction.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2013 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (6 results)

  • [Journal Article] Hideo Nakamura, Ryuji Murakami,Toshinori Hirai, Mika Kitajima,Yasuyuki Yamashita2013

    • Author(s)
      Hideo Nakamura, Ryuji Murakami,Toshinori Hirai, Mika Kitajima,Yasuyuki Yamashita
    • Journal Title

      Acta Radiol

      Volume: 54(2) Issue: 2 Pages: 214-220

    • DOI

      10.1258/ar.2012.120525

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer2012

    • Author(s)
      Keiko Teshima1, Ryuji Murakami, RyojiYoshida, Hideki Nakayama, AkimitsuHiraki, Toshinori Hirai, Yuji Nakaguchi,Naoko Tsujita, Etsushi Tomitaka,Mitsuhiro Furusawa, Yasuyuki Yamashita,Masanori Shinohara
    • Journal Title

      Journal of Radiation Research

      Volume: 53 Issue: 3 Pages: 492-496

    • DOI

      10.1269/jrr.11115

    • NAID

      130001876862

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] FDG-PET/CT-based Gross Tumor Volume Contouring for Radiation Therapy Planning: An Experimental Phantom Study2012

    • Author(s)
      Ryo Toya, Ryuji Murakami, KuniyukiTashiro, Morikatsu Yoshida, FumiSakamoto, Koichi Kawanaka, ShinyaShiraishi, Yuji Nakaguchi, NaokoTsujita, Natsuo Oya, Seiji Tomiguchi,Yasuyuki Yamashita
    • Journal Title

      Journal of Radiation Research

      Volume: 53 Issue: 2 Pages: 338-341

    • DOI

      10.1269/jrr.10183

    • NAID

      130001876819

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Double reading for grosstumor volume assessment in radiotherapyplanning2012

    • Author(s)
      Ryuji Murakami, Toshinori Hirai, RyoToya, Hideo Nakamura, YasuyukiYamashita
    • Journal Title

      Journal of Solid Tumors

      Volume: 2(4) Issue: 4 Pages: 38-43

    • DOI

      10.5430/jst.v2n4p38

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence patterns of glioblastomatreated with postoperative radiationtherapy: Relationship between extent ofresection and progression-freeinterval2012

    • Author(s)
      Ryuji Murakami, Toshinori Hirai, HideoNakamura, Mitsuhiro Furusawa, YujiNakaguchi, Hiroyuki Uetani, MikaKitajima, Yasuyuki Yamashita
    • Journal Title

      Jpn J Radiol

      Volume: 30(3) Issue: 3 Pages: 193-197

    • DOI

      10.1007/s11604-011-0031-x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 位置照合用cone-beam CT を応用した適応放射線治療の検討日本放射線技術学会雑誌2012

    • Author(s)
      丸山雅人、村上龍次、中口裕二、筧 清孝、竹永枝里子、辻田直子、大村祐貴、高田橋司、横尾崇幸、斉藤哲雄、松山知彦
    • Journal Title

      位置照合用cone-beam CT を応用した適応放射線治療の検討日本放射線技術学会雑誌

      Volume: 68(2) Pages: 162-168

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22382623

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 位置照合用cone-beam CTを応用した適応放射線治療の検討2012

    • Author(s)
      丸山雅人、村上龍次
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 68 Pages: 162-168

    • NAID

      10030139158

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FDG-PET/CT-based Gross Tumor Volume Contouring for Radiation Therapy Planning : An Experimental Phantom Study2012

    • Author(s)
      Ryo Toya, Ryuji Murakami
    • Journal Title

      J Radiat Res

      Volume: (印刷中)

    • NAID

      130001876819

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer2012

    • Author(s)
      Keiko Teshima, Ryuji Murakami
    • Journal Title

      J Radiat Res

      Volume: (印刷中)

    • NAID

      130001876862

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 6 軸カウチの線量補正に関する検討2011

    • Author(s)
      中口裕二、 村上龍次、 丸山雅人、 筧 清孝、永末 望、 荒木不次男
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 67(12) Pages: 1592-1597

    • NAID

      10030042666

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22186205

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 通常照射法におけるセットアップエラーおよび体型変化が線量分布に及ぼす影響についての検討2011

    • Author(s)
      辻田直子、 山口沙希、 村上龍次、 服部隆史、丸山雅人、 中口裕二、 筧 清孝、 斉藤哲雄、手島慶子
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 67(12) Pages: 1559-1564

    • NAID

      10030042591

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22186201

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal Changes over 2 Years inParotid Glands of Patients Treated withPreoperative 30-Gy Irradiation for OralCancer2011

    • Author(s)
      Etsushi Tomitaka, Ryuji Murakami, KeikoTeshima, Tomoko Nomura, Yuji Nakaguchi,Hideki Nakayama, Mika Kitajima,Toshinori Hirai, Yushi Araki, MasanoriShinohara, Yasuyuki Yamashita
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41(4) Issue: 4 Pages: 503-507

    • DOI

      10.1093/jjco/hyq236

    • Related Report
      2012 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 通常照射法におけるセットアップエラーおよび体型変化が線量分布に及ぼす影響についての検討2011

    • Author(s)
      辻田直子、村上龍次
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 67 Pages: 1559-1564

    • NAID

      10030042591

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 6軸カウチの線量補正に関する検討2011

    • Author(s)
      中口裕二、村上龍次
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 67 Pages: 1592-1597

    • NAID

      10030042666

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PhaseII study of preoperative concurrentchemoradiation therapy with S-1 inpatients with T4 oral squamous cellcarcinoma2010

    • Author(s)
      Tomoko Nomura, Ryuji Murakami, Ryo Toya,Keiko Teshima, Aya Nakahara, ToshinoriHirai, Akimitsu Hiraki, Hideki Nakayama,Yoshiyasu Yoshitake, Kazutoshi Ohta,Obayashi Takehisa, Yasuyuki Yamashita,Natsuo Oya, Masanori Shinohara
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 76(5) Issue: 5 Pages: 1347-1352

    • DOI

      10.1016/j.ijrobp.2009.03.055

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線治療計画のための頭部 MR 画像における膠芽腫の半自動描出2010

    • Author(s)
      堀 大輔、 桂川茂彦、 村上龍次、平井俊範
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 66(4) Pages: 353-362

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20625222

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線治療計画のための頭部MR画像における膠芽腫の半自動描出2010

    • Author(s)
      堀大輔, 桂川茂彦, 村上龍次
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 66 Pages: 353-362

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of preoperative concurrent chemoradiation therapy with S-1 in patients with T4 oral squamous cell carcinoma2010

    • Author(s)
      Tomoko Nomura, Ryuji Murakami
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 76 Pages: 1347-1352

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Clinical nodal stagingand clinical target volume forpreoperative concurrentchemoradiotherapy in patients withadvanced oral cancer2012

    • Author(s)
      Ryuji Murakami
    • Organizer
      第54回米国放射線腫瘍学会(ASTRO 2012)
    • Place of Presentation
      ボストン(米国)
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical Nodal Staging and Clinical Target Volume for Preoperative Concurrent Chemoradiotherapy in Patients with Advanced Oral Cancer2012

    • Author(s)
      Ryuji Murakami
    • Organizer
      第54回米国放射線腫瘍学会 (ASTRO 54th Annual Meeting)
    • Place of Presentation
      ボストン(米国)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Can MRI-derived factorspredict survival in patients withglioblastoma multiforme?2011

    • Author(s)
      Ryuji Murakami
    • Organizer
      第53回米国放射線腫瘍学会(ASTRO 2011)
    • Place of Presentation
      マイアミ(米国)
    • Related Report
      2012 Final Research Report
  • [Presentation] Can MRI-derived factors predict survival in patients with glioblastoma multiforme?2011

    • Author(s)
      Ryuji Murakami
    • Organizer
      第53回米国放射線腫瘍学会(ASTRO 2011)
    • Place of Presentation
      マイアミ(米国)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Recurrence patterns ofglioblastomas treated withpostoperative radiation therapy:Relationship between extent ofresection and progression-freeinterval2010

    • Author(s)
      Ryuji Murakami
    • Organizer
      第52回米国放射線腫瘍学会
    • Place of Presentation
      サンディエゴ(米国)
    • Related Report
      2012 Final Research Report
  • [Presentation] Recurrence patterns of glioblastomas treated with postoperative radiation therapy : Relationship between extent of resection and progression-free interval2010

    • Author(s)
      Ryuji Murakami
    • Organizer
      第52回米国放射線腫瘍学会(ASTRO 2010)
    • Place of Presentation
      サンディエゴ(米国)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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