New approach of radiotherapy to non-cycling tumor stem cells by repair gene inhibition
Project/Area Number |
22591391
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Keio University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KAWATA Tetsuya 慶應義塾大学, 医学部, 講師 (60234077)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ATM / NBS1 / 修復抑制 / 染色体解析 / 静止期 / 放射線抵抗性 |
Research Abstract |
Confluent normal fibroblast cells and non-cycling tumor cells were exposed to X-rays and chromosome aberrations were investigated in the first G2/M phase after exposure. Cells were subcultured 24 h with ATM and NBS1 inhibitor after exposure and chromosome
|
Report
(4 results)
Research Products
(3 results)