New approach of radiotherapy to non-cycling tumor stem cells by repair gene inhibition

Research Project

Project/Area Number	22591391
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Radiation science
Research Institution	Keio University
Principal Investigator	KAWAGUCHI Osamu 慶應義塾大学, 医学部, 講師 (90276428)
Co-Investigator(Kenkyū-buntansha)	KAWATA Tetsuya 慶應義塾大学, 医学部, 講師 (60234077)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	ATM / NBS1 / 修復抑制 / 染色体解析 / 静止期 / 放射線抵抗性
Research Abstract	Confluent normal fibroblast cells and non-cycling tumor cells were exposed to X-rays and chromosome aberrations were investigated in the first G2/M phase after exposure. Cells were subcultured 24 h with ATM and NBS1 inhibitor after exposure and chromosome

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