| Project/Area Number |
22591392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Izumi 近畿大学, 医学部附属病院, 助教 (80351633)
立花 和泉 近畿大学, 医学部附属病院, 助教 (00510984)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSONO Makoto 近畿大学, 医学部附属病院, 教授 (00281303)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 放射線治療 / 生物学 / 腫瘍 / 低酸素 / PET / 放射線療法 / 低酸素領域 / 18F-ミソニダゾール / 再酸素化現象 / 分割照射 / 強度変調放射線治療 / ^<18>F-ミソニダゾール / 効果予測 |
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| Research Abstract |
To visualize intratumoral hypoxic areas and their reoxygenation before and during fractionated radiation therapy (RT), 18F-fluoromisonidazole positron emission tomography and computed tomography (F-MISO PET/CT) were performed. Ten patients, consisting of four head and neck cancers, four gastrointestinal cancers, one lung cancer, and one uterine cancer, were included. F-MISO PET/CT was performed twice before RT and during fractionated RT of approximately 20 Gy/10 fractions for eight of the 10 patients. F-MISO maximum standardized uptake values (SUVmax) of normal muscles and tumors were measured. The tumor-to-muscle (T/M) ratios of F-MISO SUVmax were also calculated. Mean SUVmax ± standard deviation (SD) of normal muscles was 1.25 ± 0.17, and SUVmax above the mean + 2 SD (≧1.60 SUV) was regarded as a hypoxic area. Nine of the 10 tumors had an F-MISO SUVmax of equal to or more than 1.60. All eight tumors examined twice showed a decrease in SUVmax, T/M ratio, or percentage of hypoxic volume (F-MISO ≧1.60) at approximately 20 Gy, indicating reoxygenation. In conclusion, accumulation of F-MISO of ≧1.60 SUV was regarded as an intratumoral hypoxic area in our F-MISO PET/CT system. Most human tumors (90%) in this small series had hypoxic areas before RT, although hypoxic volume was minimal (0.0-0.3%) for four of the 10 tumors. In addition, reoxygenation was observed in most tumors at two weeks of the fractionated RT.
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