A fundamental study of the porphyrins as radiosensitizing materials for X-ray

• Project/Area Number: 22591395
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: TAKAHASHI Junko 独立行政法人産業技術総合研究所, 計測標準研究部門, 主任研究員 (80415702)
• Co-Investigator(Kenkyū-buntansha): MISAWA Masaki 独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (60358083) ; IWAHASHI Hitoshi 岐阜大学, 応用生物科学部, 教授 (60356540)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 放射線治療 / X 線 / 増感剤 / ポルフィリン / 5-アミノレブリン酸 / X線 / マイクロアレイ / 放射線療法 / がん / 治療 / X線増感剤 / 光線力学療法 / 担がんマウス

Research Abstract

Radiotherapy damages normal and cancerous cells, causing treatment-related side effects. To control and limit irradiation to tumor cells while sparing normal cells, we must develop methods to enhance dosing precision. 5-Aminolevulinic acid (5-ALA) is a ph

Research Products

• [Presentation] Minimally invasive protocol for evaluationg the chemical toxicity using whole blood gene expression profiles of miniature pigs (2012)
  • Author(s): Junko Takahashi, Hitoshi Iwahashi
  • Organizer: SETAC
  • Place of Presentation: Kumamoto Japan
  • Year and Date: 2012-09-27
• [Presentation] Microarray analysis of the evaluation of chemical toxicity in miniature pigs (2011)
  • Author(s): Junko Takahashi
  • Organizer: International Conference on Environmental OMICS
  • Place of Presentation: Guangzhou China
  • Year and Date: 2011-11-11
• [Presentation] Microarrya analysis of the evaluation of chemical toxicity in miniature pigs (2011)
  • Author(s): 高橋淳子
  • Organizer: 2011 International Conference of Environmental Omics (ICEO)
  • Place of Presentation: 中国
• [Presentation] Radiosensitizing effect of Gold Nanoparticles under X-ray irradiation (2010)
  • Author(s): Masaki Misawa, Junko Takahashi
  • Organizer: 1st Annual World Congress of Nanomedicene 2010
  • Place of Presentation: Beijing, Chaina
  • Year and Date: 2010-12-05
• [Presentation] Radiosensitizing Effect of Gold Nanoparticles under X-ray Irradiation (2010)
  • Author(s): Misawa M, Takahashi J
  • Organizer: 1st Annual World Congress of NanoMedicine-2010
  • Place of Presentation: 中国北京
  • Year and Date: 2010-10-25