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Development of a novel sentinel lymph node biopsy method using fluorescent nano-particles

Research Project

Project/Area Number 22591396
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

KAMEI Takashi  東北大学, 病院, 講師 (10436115)

Co-Investigator(Kenkyū-buntansha) OHCHI Noriaki  東北大学, 大学院・医学系研究科, 教授 (90203710)
GONDA Kosuke  東北大学, 大学院・医学系研究科, 准教授 (80375435)
TANIYAMA Yusuke  東北大学, 病院, 助教 (00622987)
里見 進  東北大学, 病院, 教授 (00154120)
星田 徹  東北大学, 病院, 助教 (30444011)
日景 允  東北大学, 大学院・医学系研究科, 非常勤講師 (70579747)
武田 元博  東北大学, 大学院・医学系研究科, 准教授 (10333808)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsセンチネルリンパ節 / ナノ粒子トレーサー / 高感度蛍光計測 / 病理診断 / 蛍光粒子 / ナノスケール / リアルタイムイメージング / リンパ節転移
Research Abstract

We succeeded in real-time fluorescent imaging of sentinel lymph nodes of various gastrointestinal tracts in pig model using QDs as a tracer. After that, we analyzed fluorescent specificities in varied conditions and revealed the range of a signal detection through fat tissue or other organs. Furthermore, we developed novel organic material nanoparticles as a safety fluorescent probe for sentinel lymph node biopsy(SLNB) with the idea of clinical application. We revealed that these particles were suitable for SLNB and their fluorescent specificities were similar to the QDs.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] Fabrication andfluorescence properties of multilayered core-shell particles composed of quantum dot, gadolinium compound, and silica2012

    • Author(s)
      Kobayashi Y, Nozawa T, Nakagawa T, GondaK, Takeda M, Ohuchi N.
    • Journal Title

      J Mater Sci

      Volume: 47 Issue: 4 Pages: 1852-1859

    • DOI

      10.1007/s10853-011-5972-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Au-silica core-shell particles by sol-gel process2012

    • Author(s)
      Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A.
    • Journal Title

      Surface Engineering

      Volume: 28(2) Pages: 129-133

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] X-ray imaging ofnewly-developed gadolinium compound/silica core-shell particles2012

    • Author(s)
      Hikaru Morimoto, Marie Minato, Tomohiko Nakagawa, Masahide Sato, Yoshio Kobayashi, Kohsuke Gonda, Motohiro Takeda, Noriaki Ohuchi, Noboru Suzuki.
    • Journal Title

      Journal of Sol-Gel Science and Technology

      Volume: 59(3) Issue: 3 Pages: 650-657

    • DOI

      10.1007/s10971-011-2540-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a quantitative diagnostic method of estrogen receptor expression levels by immunohistochemistry using organic fluorescent material-assembled nanoparticles2012

    • Author(s)
      Gonda K, Miyashita M, Watanabe M, Takahashi Y, Goda H, Okada H, Nakano Y, Tada H, Amari M, Ohuchi N.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 426(3) Pages: 409-14

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体名のイメージングによる血管新生メカニズムの解析2012

    • Author(s)
      大内憲明
    • Journal Title

      ナノ医工学年報

      Volume: 5巻 Pages: 211-220

    • Related Report
      2012 Final Research Report
  • [Journal Article] 生体ナノイメージングによる血管新生メカニズムの解析2012

    • Author(s)
      大内憲明
    • Journal Title

      ナノ医工学年報

      Volume: 5巻 Pages: 211-220

    • NAID

      40019250282

    • Related Report
      2012 Annual Research Report
  • [Journal Article] がん転移の生体ナノイメージング2011

    • Author(s)
      権田幸祐、大内憲明, 他
    • Journal Title

      生物物理

      Volume: 51巻 Pages: 82-83

    • NAID

      10028105819

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ナノイメージングで探る癌転移の仕組み2011

    • Author(s)
      権田幸祐, 他
    • Journal Title

      Surgery Frontier

      Volume: 18巻 Pages: 50-57

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] In vivo imaging of the molecular distribution of the VEGF receptor during angiogenesis in a mouse model of ischemia2011

    • Author(s)
      Hamada Y, Gonda K, Takeda M, Sato A, Watanabe M, Yambe T, Satomi S, Ohuchi N.
    • Journal Title

      Blood

      Volume: 29:118(13)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of shell thickness in silica-coating of Au nanoparticles and their X-ray imaging properties2011

    • Author(s)
      Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuya A.
    • Journal Title

      J Colloid Interface Sci

      Volume: 358 Pages: 329-333

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] QDをトレーサーとした近赤外蛍光内視鏡下手術システムの検討2012

    • Author(s)
      亀井尚、大内憲明
    • Organizer
      第25回日本内視鏡外科学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-12-06
    • Related Report
      2012 Final Research Report
  • [Presentation] CT Imaging of Tumor with Silica Coated Au Nanoparticle 5th International Symposium on Nanomedicine2012

    • Author(s)
      Tomohiko Nakagawa, Kohsuke Gonda, Yoshio Kobayashi,Takashi Kamei, Liman Cong, Hiromitsu Inose, Ryoko Nagasu and Noriaki Ohuchi
    • Organizer
      Nagoya University ES Hall
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 金ナノ粒子を用いた腫瘍のCTイメージング2012

    • Author(s)
      中川智彦、権田幸祐、亀井尚、叢莉蔓、久保田洋介、大内憲明
    • Organizer
      ナノ学会第10回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] QDをトレーサーとした近赤外蛍光内視鏡下手術システムの検討2012

    • Author(s)
      亀井尚
    • Organizer
      第25回日本内視鏡外科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 先端技術の内視鏡外科への応用蛍光内視鏡下手術の開発2010

    • Author(s)
      亀井尚、日景允, 他
    • Organizer
      第23回日本内視鏡外科学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-18
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Biodistribution of Novel Silica-Coated Nano-Particles for Fluorescence and CT Imaging in Tumor-Bearing Mice2010

    • Author(s)
      Tomohiko Nakagawa, Kohsuke Gonda, Motohiro Takeda, Takashi Kamei, Yoshio Kobayashi, Hiromitsu Inose, Takuya Nozawa, Hikaru Morimoto and Noriaki Ohuchi
    • Organizer
      4th East Asian Pacific Student Workshop onNano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore (NUS), Singapore
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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