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Experimental evaluation of a silk fibroin-coated vascular prosthesis

Research Project

Project/Area Number 22591398
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionThe University of Tokyo

Principal Investigator

SHIGEMATSU Kunihiro  東京大学, 医学部附属病院, 講師 (20215966)

Co-Investigator(Kenkyū-buntansha) MIYATA Tetsurou  東京大学, 医学部附属病院, 准教授 (70190791)
KOYAMA Hiroyuki  東京大学, 医学部附属病院, 特任准教授 (10241994)
OKAMOTO Hiroyuki  東京大学, 医学部附属病院, 特任講師 (60348266)
木村 秀生  東京大学, 医学部附属病院, 助教 (60327070)
Co-Investigator(Renkei-kenkyūsha) ASAKURA Tetsuo  東京農工大学, 共生科学技術研究科, 教授 (30139208)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords血管外科学 / 人工血管 / 血管外科
Research Abstract

Polyester vascular grafts coated with silk fibroin or gelatin were implanted in the abdominal aorta and common carotid arteries of dogs. In contrast to gelatin-coated grafts, silk fibroin-coated grafts had less collagenous intimal layer with endothelial-like cells. These findings suggest that silk fibroin-coated graft might provide excellent patency of small-diameter vascular graft.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 Other

All Presentation (2 results) Remarks (3 results)

  • [Presentation] 絹タンパク(フィブロイン)の人工血管材料としての使用経験2012

    • Author(s)
      岡本宏之
    • Organizer
      第53回日本脈管学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 絹タンパク(フィブロイン)の人工血管材料としての使用経験

    • Author(s)
      岡本宏之
    • Organizer
      第53回日本脈管学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Remarks] 血管外科ホームページ

    • URL

      http://all-1su.umin.jp/vascular/staff.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://all-lsu.umin.jp/vascular/staff.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://all-lsu.umin.jp/vascular/staff.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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