Development of pre-transplant assessments that predict AntibodyMediated Rejection(AMR)
| Project/Area Number |
22591403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
MIWA Yuko 名古屋大学, 医学系研究科, 研究員 (90572941)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takaaki 名古屋大学, 大学院・医学系研究科, 寄附講座教授 (70314010)
HANEDA Masataka 名古屋大学, 大学院・医学系研究科, 寄附講座講師 (50436995)
IWASAKI Kenta 名古屋大学, 大学院・医学系研究科, 寄附講座講師 (10508881)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 移植外科学 / 抗体関連型拒絶反応 / 補体 / 凝固系制御 / ABO不適合腎移植 / 移植前検査 / 移植・再生医療 / 拒絶反応 / 凝固系 / 抗原、抗体、補体 |
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| Research Abstract |
Current pre-transplant assessment in ABO-incompatible organ transplantation is only measurement of anti-A/B antibody titer in recipient serum. Although levels of A/B antigen expression on vascular endothelial cells (EC) of donor graft are considered to be important in immune response, there is no method for quantification. We examined A/B antigen expression levels in donor platelet (plt) that might predict levels of A/B antigen expression on EC. Expression levels of A/B antigen in Plt varied among patients. There was over 30-fold difference between the highest and lowest levels. However A/B antigens were constantly expressed in EC, and no inter-individual difference was observed. Effectiveness was not obtained in measurement of A/B expressionin donor Plt. This result suggested that the development of novel pre-transplant assessment to predict immune response and clinical outcome would be required.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Production of cloned pigs expressing human thrombomodulin in endothelial cells2012
Author(s)
Yazaki S, Iwamoto M, Onishi A, Miwa Y, Hashimoto M, Oishi T, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Liu D, Nagasaka T, Kuzuya T, Ogawa H, Yamamoto K, Iwasaki K, Haneda M, Maruyama S, Kobayashi T.
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Journal Title
Xenotransplantation
Volume: 19
Issue: 2
Pages: 82-91
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparative study on signal transduction in endothelial cells after anti-A/B and HLA antibody reaction : implication of accommodation2012
Author(s)
Iwasaki K, Miwa Y, Ogawa H, Iwamoto M, Furusawa T, Onishi A, Kuzuya T, Haneda M, Watarai Y, Uchida K, Kobayashi T.
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Journal Title
Transplantation
Volume: 93
Issue: 4
Pages: 390-397
DOI
Related Report
Peer Reviewed
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[Presentation] Effective Suppression of Direct Prothrombinase Activity in Porcine Endothelial Cells by Human Thrombomodulin(hTM)Gene Transfer or Its Soluble Form2010
Author(s)
Yuko Miwa, Satoko Yazaki, Masaki Iwamoto, Akira Onishi, Koji Yamamoto, Kenta Iwasaki, Masataka Haneda, Shoichi Maruyama, Kenji Kadomatsu, Kazuharu Uchida, Takaaki Kobayashi
Organizer
MERICAN TRANSPLANT CONGRESS
Place of Presentation
San Diego (USA)
Related Report
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