| Project/Area Number |
22591403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
MIWA Yuko 名古屋大学, 医学系研究科, 研究員 (90572941)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takaaki 名古屋大学, 大学院・医学系研究科, 寄附講座教授 (70314010)
HANEDA Masataka 名古屋大学, 大学院・医学系研究科, 寄附講座講師 (50436995)
IWASAKI Kenta 名古屋大学, 大学院・医学系研究科, 寄附講座講師 (10508881)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 移植外科学 / 抗体関連型拒絶反応 / 補体 / 凝固系制御 / ABO不適合腎移植 / 移植前検査 / 移植・再生医療 / 拒絶反応 / 凝固系 / 抗原、抗体、補体 |
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| Research Abstract |
Current pre-transplant assessment in ABO-incompatible organ transplantation is only measurement of anti-A/B antibody titer in recipient serum. Although levels of A/B antigen expression on vascular endothelial cells (EC) of donor graft are considered to be important in immune response, there is no method for quantification. We examined A/B antigen expression levels in donor platelet (plt) that might predict levels of A/B antigen expression on EC. Expression levels of A/B antigen in Plt varied among patients. There was over 30-fold difference between the highest and lowest levels. However A/B antigens were constantly expressed in EC, and no inter-individual difference was observed. Effectiveness was not obtained in measurement of A/B expressionin donor Plt. This result suggested that the development of novel pre-transplant assessment to predict immune response and clinical outcome would be required.
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