| Project/Area Number |
22591405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University (2011-2013)
Kyoto University (2010) |
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Principal Investigator |
OGURA Yasuhiro 名古屋大学, 医学部附属病院, 病院准教授 (20335251)
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| Co-Investigator(Kenkyū-buntansha) |
UEMOTO Shinji 京都大学, 医学系研究科(研究院), 教授 (40252449)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 心停止ドナー / 肝移植 / 温粗血時間 / 温粗血時間延長 |
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| Research Abstract |
Liver transplant outcomes using grafts donated after cardiac death (DCD) remain poor. Our goal of this study was to extend the warm ischemic time in rat liver transplantation from DCD donors. For this purpose, it is important to control the ischemic/reperfusion (I/R) injury after transplantation. There are a couple of reports to prevent I/R injury, and we applied venous systemic oxygen persufflation (VSOP) and nitric oxide (NO) gas administration.
Using rat liver transplantation models from 60 minutes DCD donors, VSOP-NO treatment could effectively decreasing the damage of I/R injury, leading to the better survival. However, we failed to extend the warm ischemic time by this methods. There may be a limitation in these graft reconditioning procedures, further investigation to understand this phenomena is required.
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