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Measuring human complement activation for antibody mediated rejection

Research Project

Project/Area Number 22591407
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionEhime University

Principal Investigator

WATANABE Jota  愛媛大学, 大学院・医学系研究科, 講師 (40403802)

Co-Investigator(Kenkyū-buntansha) TAKADA Yasutsugu  愛媛大学, 大学院・医学系研究科, 教授 (10272197)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords臓器移植 / 抗体関連型拒絶反応 / 補体 / γ-グロブリン / 移植医療 / フローサイトメトリ / 超急性拒絶反応 / Bリンパ球
Research Abstract

In transplantation, various antibodies cause antibody mediated rejection. The clinical significance of HLA antibodies depends on their ability to activate complement (C). The requirements of HLA antibodies to activate human C are not known. Direct C3b measurement on target cells may by a better indication of the ability of HLA antibodies to activate human C than standard cytotoxicity. Human C3b deposition was influenced more by the particular serum/cell combination under study than by the amount of IgG, with some combinations showing high IgG and low C3b and others showing low IgG and high C3b. IVIG produced significant dose-dependent complement inhibition. Measuring human C component may improve the assessment of donor-recipient compatibility. IVIG is useful for reducing antibody mediated rejection.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] 臓器移植における抗体関連型拒絶反応に対する補体活性化計測システムの開発2013

    • Author(s)
      渡邊常太、串畑史樹、高田泰次
    • Journal Title

      愛媛医学

      Volume: 第32巻 1号 Pages: 51-57

    • Related Report
      2012 Final Research Report
  • [Journal Article] 臓器移植における抗体関連型拒絶反応に対する補体活性化計測システムの開発2013

    • Author(s)
      渡邊常太
    • Journal Title

      愛媛医学

      Volume: 32巻 Pages: 51-57

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] IVIG のHLA 抗体に対する補体抑制効果について2012

    • Author(s)
      愛媛大学 肝胆膵・移植外科 渡邊常太、串畑史樹、高田泰次
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 臓器移植における超急性拒絶反応抑制の試みについて2012

    • Author(s)
      愛媛大学 肝胆膵・移植外科 渡邊常太、串畑史樹、高田泰次
    • Organizer
      第30回日本肝移植研究会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] IVIGのHLA抗体に対する補体抑制効果について2012

    • Author(s)
      渡邊常太
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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