| Project/Area Number |
22591413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
ISHITANI Akiko 奈良県立医科大学, 医学部, その他 (40112544)
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| Co-Investigator(Kenkyū-buntansha) |
OUJI Noriko (SAGESHIMA Noriko) 奈良県立医科大学, 医学部, 助教 (30398432)
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| Co-Investigator(Renkei-kenkyūsha) |
ICHINOHE Tatsuo 広島大学, 医学系研究科, 教授 (80314219)
UEMOTO Shinji 京都大学, 医学系研究科, 教授 (40252449)
TAKAHARA Shiro 大阪大学, 医学系研究科, 教授 (70179547)
MORII Takeshi 奈良県立医科大学, 医学部, 講師 (70264851)
YOSHIDA Katsunori 奈良県立医科大学, 医学部, 教授 (50192422)
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| Project Period (FY) |
2010-10-20 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | HLA-G / 移植 / 移植片生着 / 腎移植 / 肝移植 / 造血幹細胞移植 / 可溶性HLA-G / 免疫寛容 / 生着 |
|---|
| Research Abstract |
Recently, the number of reports suggesting that HLA-G expression in blood after solid organ and hematopoietic stem cells transplants being associated with successful transplantation has been increasing. To address these findings, we reexamined HLA-G protein expression in kidney, liver and hematopoietic stem cell transplantation. These studies revealed HLA-G expression on peripheral mononuclear cells from patients before or after transplantation, but found no significant association of HLA-G expression with successful transplantation. We also detected HLA-G protein in plasma from patients by ELISA, although we were unable to confirm HLA-G protein in these samples by western analysis.
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