Development of novel therapy targeting IL-17 in tumor microenvironment
| Project/Area Number |
22591415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IWAHASHI Makoto 和歌山県立医科大学, 医学部, 准教授 (70244738)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki (NAKAMURA Masaki / OJIMA Toshiyasu) 和歌山県立医科大学, 医学部, 教授 (20191190)
尾島 敏康 和歌山県立医科大学, 医学部, 助教 (60448785)
中村 公紀 和歌山県立医科大学, 医学部, 講師 (80364090)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 外科総論 / IL-17 / 腫瘍 / 血管新生 / 抗腫瘍免疫 / 癌微小環境 / MMP9 / 腫瘍浸潤リンパ球 / アデノウイルスベクター / siRNA / 腫瘍増殖 |
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| Research Abstract |
MC38 or B16 cells were inoculated subcutaneously into mice, and intratumoral injection of an adenovirus vector expressing siRNA against the mouse IL-17A gene (Ad-si-IL-17) significantly inhibited tumor growth in both tumor models compared with control mice. Blockade of IL-17A at tumor sites helped suppress tumor growth by inhibiting angiogenesis as well as activating antitumor immunity at tumor sites
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Inhibition of IL-17A in tumor microenvironment augments cytotoxicity of tumor-infiltrating lymphocytes in tumor-bearing mice2013
Author(s)
Hayata K, Iwahashi M, Ojima T, Katsuda M, Iida T, Nakamori M, Ueda K, Nakamura M, Miyazawa M, Tsuji T,Yamaue H
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Journal Title
PLoS One
Volume: 8(1)
Issue: 1
Pages: e53131-e53131
DOI
Related Report
Peer Reviewed
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