Application of Serum Antibodies against c-myc to Malignant Solid Tumors
Project/Area Number |
22591416
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Toho University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | SEREX / serum antibody / c-myc / malignant tumor / VEGF / p53 / ELISA / 固形癌 / 血清抗体 / 腫瘍マーカー |
Research Abstract |
Purpose of this study was (i) establish ELISA system to detect serum anti-c-myc antibodies, and (ii) evaluate positive rate of serum anti-c-myc antibodies in patients with malignant solid tumors. Using a cut-off value of mean +3SD of serum anti-c-myc antibody level of healthy controls, positive rate of patients were evaluated. Various kind of serum samples from stage I or stage II cancer patients were analyzed for serum c-myc antibodies. The positive rates were prostae cancer=8%, lung cancer=9%, gastric cancer=14%, colon cancer=6%, breastcancer=13%, esophageal cancer=12%, liver cancer=10%, respectively. No clinicopathological factors were associated with presence of anti-c-myc antibodies. Plural serum antibodiescan increase sensitivity to detect cancer.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] SAP155-mediated c-myc suppressor FBP-interacting repressor splicing variants are activated in colon cancer tissues2013
Author(s)
Kajiwara T, Matsushita K, Itoga S, Tamura M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Habara Y, Matsuo M, Nomura F
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Journal Title
Cancer Sci
Volume: 104(2)
Issue: 2
Pages: 149-156
DOI
Related Report
Peer Reviewed
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[Journal Article] SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression2012
Author(s)
Matsushita, K., Kajiwara, T., Tamura, M., Satoh, M., Tanaka, N., Tomonaga, T., Matsubara, H., Shimada, H., Yoshimoto, R., Ito, A., Kubo, S., Natsume, T., Levens, D., Yoshida, M., and Nomura, F
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Journal Title
Mol. Cancer Res
Volume: 10
Issue: 6
Pages: 787-799
DOI
Related Report
Peer Reviewed
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[Journal Article] Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed2012
Author(s)
Li, Q., Kawamura, K., Okamoto, S., Yamanaka, M., Yang, S., Yamauchi, S., Fukamachi, T., Kobayashi, H., Tada, Y., Takiguchi, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
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Journal Title
Cancer Gene Ther
Volume: 19
Issue: 3
Pages: 218-228
DOI
Related Report
Peer Reviewed
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[Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in treatment of malignant pleural mesothelioma2011
Author(s)
Kitamura A, Matsushita K, Takiguchi Y, Shimada H, Tada Y, Yamanaka M, Hiroshima K, Tagawa M, Tomonaga T, Matsubara H, Inoue M, Hasegawa M, Sato Y, Levens D, Tatsumi K, Nomura F
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Journal Title
Cancer Sci
Volume: 102
Issue: 7
Pages: 1366-73
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 島田英昭, 谷島 聡, 小池淳一, 田川雅敏, 竹田明彦, 松下一之, 日和佐隆樹, 野村文夫2011
Author(s)
島田英昭, 谷島 聡, 小池淳一, 田川雅敏, 竹田明彦, 松下一之, 日和佐隆樹, 野村文夫
Organizer
第70回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2011-10-05
Related Report
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[Presentation] Serum SEREX antibodies as new biomarkers for stage I/II gastric cancer.2010
Author(s)
Shimada H, Yamazaki K, Yajima S, Ooshima Y, Nanami T, Tamura A, Tsuchiya M, Maeda T, Suzuki T, Ootsuka Y, Kaneko H
Organizer
The 7th International Symposium on Cancer Research and Therapy
Place of Presentation
東京會舘(東京都)
Year and Date
2010-11-27
Related Report
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