Elucidation of the biological properties of triple negative breast cancer and construction of a therapeutic strategy
| Project/Area Number |
22591421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHIDA Takanori 東北大学, 大学院・医学系研究科, 准教授 (00292318)
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| Co-Investigator(Kenkyū-buntansha) |
OHCHI Noriaki 東北大学, 大学院・医学系研究科, 教授 (90203710)
AMARI Masakazu 東北大学, 大学院・医学系研究科, 准教授 (50400312)
WATANABE Mika 東北大学, 病院, 准教授 (20292344)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYASHITA Minoru 東北大学, 病院, 助教 (60710788)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 乳癌 / トリプルネガティブ / リスクスコア / Basal type / Ki-67 labeling index / Microvessel Density / 乳がん / 遺伝子プロファイリング |
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| Research Abstract |
Triple negative breast cancer observed high histological grade, further vascular invasion, high vascularization and proliferation potential. Results of our study demonstrated that triple negative breast cancer could be further sub-classified into three different groups (low, intermediate, high) according to the Risk Score System evaluating the following five prognostic variable (pathological tumor size, pathological node status, basal-like type, Ki67 labeling index and Microvessel Density). Difference was observed in the survival rate significantly in these three groups. In conclusion, this classification is useful as a therapeutic decision-making tool for triple negativepatients.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Analysis of clinically relevant values of Ki-67 labeling index in Japanese breast cancer patients. Breast Cancer2012
Author(s)
Tamaki K, Ishida T, Tamaki N, Kamada Y, Uehara K, Miyashita M, Amari M, Tadano-Sato A, Takahashi Y, Watanabe M, McNamara K, Ohuchi N, Sasano H.
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Peer Reviewed
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