The responsiveness of ALDH1-positive cells to chemotherapy in metastatic lesions and its prognostic significance in patients with breast cancer
| Project/Area Number |
22591423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Takeshi 千葉大学, 医学部附属病院, 講師 (60292710)
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳腺外科学 / 転移性乳癌 / ホスト環境 / 癌幹細胞ニッチ / シナプス / 環境移植 / ALDH1 / Tenascin C / プロテオミクス / 細胞間マトリックス |
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| Research Abstract |
In this study, the responsiveness of ALDH1-positive cells to chemotherapy in primary and metastatic lesions and its associated prognostic significance were revealed in patients with breast cancer. ALDH1-positive cells may represent a surrogate marker as a new concept in patients with lymph node-positive breast cancer. In the future, ALDH1-positive cells may be used for diagnosis and treatment, and these cell populations could be targeted in the development of new chemotherapies. We hope that our results will provide basic data for therapies targeting cell subpopulations in tumors,rather than the whole body, in patients with noncurable, metastatic breast cancer.
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Report
(4 results)
Research Products
(6 results)
