• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basic and clinical research toward the development of treatment with HDAC inhibitors for breast cancer

Research Project

Project/Area Number 22591425
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKanazawa University

Principal Investigator

INOKUCHI Masafumi  金沢大学, 大学病院, 助教 (90401918)

Co-Investigator(Kenkyū-buntansha) OHTA Tetsuo  金沢大学, 医学系, 教授 (40194170)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords乳腺外科学 / エピジェネティックス
Research Abstract

We focused on valproic acid (VPA), an anticonvulsant drug, which has been reported as histone deacetylase (HDAC) inhibitor, and researched for the new therapeutic development of breast cancer using VPA. We confirmed VPA suppressed the proliferation of breast cancer cell lines in each subtypes in the concentrations equivalent to those used for the clinical treatment in concentration-dependent to varying degrees. We also confirmed VPA induced breast cancer cells to differentiation and apoptosis. We showed the anti-proliferative mechanism of VPA might be associated with not only the direct function of acetylation of histone, through cell cycle arrest or apoptosis, but also indirect function that that acetylation of HSP70 disrupted the function of HSP90 and led to down-regulation of its client proteins such as HER2.
This study suggests combination of standard treatment for breast cancer and VPA can be useful in terms of proliferative suppression of cancer in the future.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] バルプロ酸ナトリウムのHDAC阻害剤としての乳癌細胞抑制機序の検討2013

    • Author(s)
      馬渡俊樹、井口雅史、二宮致、高村博之、北川裕久、伏田幸夫、藤村隆、太田哲生
    • Organizer
      第51回日本癌治療学会学術総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Final Research Report
  • [Presentation] バルプロ酸ナトリウムのHDAC阻害薬としての乳癌細胞増殖抑制機序の検討2013

    • Author(s)
      馬渡俊樹、井口雅史、二宮致、高村博之、北川裕久、伏田幸夫、藤村隆、太田哲生
    • Organizer
      第51回日本癌治療学会学術総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi