Detection of novel cancer-related genes by using triple combination array analysis
Project/Area Number |
22591427
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Nagoya University |
Principal Investigator |
NOMOTO Shuji 名古屋大学, 医学部附属病院, 病院講師 (40300967)
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Co-Investigator(Kenkyū-buntansha) |
KASUYA Hideki 名古屋大学, 大学院・医学系研究科, 准教授 (00402636)
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70167542)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | トリプルアレイ法 / 発現アレイ / SNP アレイ / メチレーションアレイ / 消化器癌 / SNPアレイ / トリプルアレイ / メチル化アレイ / 肝細胞癌 / 胃癌 / がん関連遺伝子 / バイオマーカー |
Research Abstract |
It has been known that cancer is a disease associated with the genetic abnormality. Various array technologies have been used to extract genes which were related tumor initiation and progression. We have devised a triple combination array analysis which was consisted the expression array, the SNP array, and the methylation array to identify tumor related genes. We could predict prognosis and/or recurrence using some of the extracted genes.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method2011
Author(s)
Yukiyasu Okamura, Shuji Nomoto, Masamichi Hayashi, Mitsuhiro Hishida, Yoko Nishikawa, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Shin Takeda, Yasuhiro Kodera, Akimasa Nakao
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Journal Title
Cancer Letters
Volume: 312(2)
Issue: 2
Pages: 150-157
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method2011
Author(s)
Okamura Y, Nomoto S, Hayashi M, Hishida M, Nishikawa Y, Yamada S, Fujii T, Sugimoto H, Takeda S, Kodera Y, Nakao A
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Journal Title
Cancer Letter
Volume: Dec 22:312(2)
Pages: 150-7
Related Report
Peer Reviewed
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